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Cytokines and reagents that can be added to cell cultures and used to investigate a variety of cell pathways and metabolic processes. Products also include a variety of kits, immunoassays, arrays, and staining products for use in cytokine analysis experiments.
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AITRL a type II transmembrane protein is a ligand for glucocorticoid-induced TNFR-related protein (GITR) When AITRL binds to GITR GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions GITR/AITRL interaction plays a role in the pathogenesis of tumor inflammation as well as autoimmune diseases[1] Besides AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1 ICAM-1)[2] AITRL/TNFSF18 Protein Mouse is a recombinant mouse AITRL (T47-S173) without tag which is expressed in E coli
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The V-PLEX Human Cytokine 30-plex Kit from Meso Scale Discovery is a multiplex immunoassay that simultaneously measures 30 human cytokines and chemokines in a single small sample volume The kit includes a 96-well plate pre-coated with capture antibodies detection antibodies calibrators controls buffers and reagents for quantitative analysis of cytokines including IL-1 IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-10 IL-12p70 IL-13 IL-15 IL-16 IL-17A TNF- IFN- GM-CSF VEGF Eotaxin IP-10 MCP-1 MIP-1 MIP-1 RANTES EGF FGF-2 G-CSF HGF and PDGF-BB The kit utilizes MSD s electrochemiluminescent detection technology for high sensitivity and broad dynamic range
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The V-PLEX Plus Cytokine Panel 1 Human Kit from Meso Scale Discovery is a multiplex immunoassay measuring 10 human cytokines and chemokines (IFN- IL-10 IL-12p70 IL-13 IL-1 IL-2 IL-4 IL-6 IL-8 TNF- ) in various biological fluids Utilizing patented MULTI-ARRAY technology it runs on the MESO QuickPlex SQ 120 instrument The kit includes a 96-well plate with capture antibodies detection antibodies Read Buffer Diluent 2 Calibrator Blend and controls enabling quantitative cytokine determination with high sensitivity wide dynamic range and minimal sample volume
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Interleukin 6 (IL-6) is secreted by T cells and macrophages and acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Some of its functions include the stimulation of the immune response during infection induction of fever in autoimmune infectious and non-infectious diseases the stimulation of acute phase reactions differentiation of T cells proliferation and differentiation of B-cells the development of blood cells as well as the activation of osteoclasts and osteoporosis and the secretion of vascular endothelium growth factor (VEfG) to increase blood vessel growth and vascular permeability in inflammation. It is important for a short-term defense against infection injury and inflammation however dysregulation of IL-6 results in disease.IL-6 is important in the study of diseases such as diabetes lupus multiple myeloma rheumatoid arthritis and some cancers such as prostate and pancreatic cancer. Conversely deficiency of IL-6 can have an effect on immune
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The V-PLEX Mouse Cytokine 19-plex Kit from Meso Scale Discovery is a multiplex immunoassay for measuring 19 mouse cytokines and chemokines (e g IL-1 IL-6 TNF- VEGF) from a single sample It uses electrochemiluminescence detection for high sensitivity and broad dynamic range with low sample volume The kit includes a 96-well plate with capture antibodies detection antibodies calibrators controls buffers and seals Suitable for mouse serum plasma tissue culture supernatants and other fluids
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The U-PLEX Chemokine Combo 1 Mouse Kit from Meso Scale Discovery is a multiplex immunoassay that simultaneously measures mouse CCL2 CCL3 CCL4 CCL5 CXCL1 CXCL2 CXCL5 CXCL9 CXCL10 and CXCL13 in serum plasma and cell culture supernatants This 10-plex assay utilizes MSD s electrochemiluminescent detection technology and provides high sensitivity up to a 7-log dynamic range and requires as little as 25 L of sample The kit includes a 96-well plate coated with capture antibodies detection antibodies read buffer wash buffer diluent and calibrators
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