Isotopically Labeled Compounds
Medchemexpress LLC Zidovudine-d4 (Azidothymidine-d4) | 30516-87-1 | 271.27 | C10H9D4N5O4 | 10 MG
Zidovudine-d4 (Azidothymidine-d4) is a deuterium-labeled analogue of zidovudine supplied for research and analytical applications. It is intended as an internal standard or tracer for mass spectrometry, quantitative assays, and method development in HIV-related studies. The labeled compound enables clear mass differentiation from the native drug during analysis.
- Deuterium-labeled internal standard for mass spectrometry.
- Suitable for analytical quantitation and method development.
- Provided as a 10 mg research-grade solid for laboratory use.
- Molecular formula C10H9D4N5O4 and molecular weight 271.27 for accurate calculations.
- Certificate of analysis available from the manufacturer for purity and quality control.
Medchemexpress LLC (Rac)-Rivastigmine-d6 | 194930-04-6 | 256.37 | 1 MG
(Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor, inhibiting butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). It can cross the blood-brain barrier and is a parasympathomimetic or cholinergic agent used in research for mild to moderate Alzheimer's type dementia and Parkinson's disease dementia. Stable heavy isotopes, such as deuterium, incorporated into drug molecules are used as tracers for quantitation during drug development and can influence pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Octanoic acid-d3 | 156779-05-4 | 99.1% | 147.23 | 50 MG
Octanoic acid-d3 (Caprylic acid-d3) is the deuterium labeled Octanoic acid. Octanoic acid is an oily liquid with a slightly unpleasant rancid taste and is used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Cayman Chemical Bosentan-d4, Purity: ≥99% deuterated forms (d1-d4), CAS: 1065472-77-6, 25 mg
An internal standard for the quantification of bosentan by GC- or LC-MS
Medchemexpress LLC Fulvestrant-d5 | 129453-61-8 | 99.66% | 611.80 | 1 MG
Fulvestrant-d5 (ICI 182780-d5) is an isotope of Fulvestrant and a potent estrogen receptor (ER) antagonist. It effectively inhibits the growth of ER-positive MCF-7 cells and induces autophagy, demonstrating antitumor efficacy. This compound serves as a valuable tool for various analytical applications.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Contains stable heavy isotopes for quantitation during drug development
Medchemexpress LLC Ftísadtsk-13c 6,15n2(tfa) | 96.04% | 1091.01 | 10 MG
FTISADTSK-13C6,15N2 TFA is a 13C- and 15N-labeled peptide that serves as an endogenous stable signature peptide from Trastuzumab. It is monitored by selected reaction monitoring (SRM) and utilized as a tracer for quantitation during drug development.
- 13C- and 15N-labeled peptide
- Stable signature peptide from Trastuzumab
- Monitored by selected reaction monitoring (SRM)
- Used as a tracer for quantitation in drug development
Medchemexpress LLC Olanzapine-d3 | 786686-79-1 | 99.1% | 315.45 g·mol⁻¹ | C17H17D3N4S | 5 MG
Olanzapine-d3 is the deuterium-labeled analogue of olanzapine used as an internal standard and analytical reference for quantitative bioanalysis. It enables mass-differentiated detection in LC-MS/MS workflows, improving accuracy and precision when measuring olanzapine in biological samples.
- Deuterated internal standard for LC-MS/MS assays.
- Enables mass-differentiated detection for accurate quantitation.
- High chemical purity (99.1%) for reliable analytical performance.
- Molecular weight 315.45 g·mol⁻¹ and formula C17H17D3N4S.
- Suitable for use in plasma, serum, and other biological matrices.
- Supplied as a small solid aliquot suitable for calibration and method development.
Medchemexpress LLC Sphingosine-1-phosphate | 26993-30-6 | 99.5% | 379.47 | 10 MG
Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6, and GPR12. It functions as an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. S1P is a crucial lipid mediator generated from Sphingomyelin or other membrane phospholipids and stimulates DNA synthesis, cell proliferation, and migration.
- Agonist for S1P1-5 receptors
- Ligand for GPR3, GPR6, and GPR12
- Functions as an intracellular second messenger
- Mobilizes Ca2+ as an extracellular ligand
- Crucial lipid mediator
- Stimulates DNA synthesis, cell proliferation, and migration
- High purity
- Solid appearance, white to yellow color
- For research use only
Medchemexpress LLC Aspirin-d3 | 921943-73-9 | >99.8% | 183.18 | 1 ML
Aspirin-d3, also known as Acetylsalicylic acid-d3 or ASA-d3, is a deuterium-labeled form of Aspirin. This orally active compound acts as a potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2. It has been shown to induce apoptosis and inhibit the activation of NF-κB, offering potential in preventing coronary artery and cerebrovascular thrombosis.
- Deuterium labeled aspirin
- Potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2
- Induces apoptosis
- Inhibits activation of NF-κB
- May prevent coronary artery and cerebrovascular thrombosis
Cambridge Isotope Laboratories DL-Homocysteine (3 3 4 4-D4 98%) 5 mg
DL-Homocysteine (3 3 4 4-D4 98%) 5 mg
Medchemexpress LLC Ponesimod-d7 | 00-00-0 | MFCD18207776 | 468.02 g·mol⁻1 | C23H18D7ClN2O4S | 5 MG
Ponesimod-d7 is the deuterium-labeled analogue of ponesimod provided for research use as an isotopic tracer. It retains the parent compound's pharmacological profile while introducing a mass shift that enables unambiguous detection in mass-spectrometry assays. Typical properties include molecular formula C23H18D7ClN2O4S and molecular weight 468.02 g·mol⁻1.
- Deuterium-labeled analogue suitable for tracer studies.
- Enables mass-shift detection in LC-MS assays.
- Useful for metabolic and pharmacokinetic investigations.
- Provided as a stable powder for analytical workflows.
- Storage recommendations: powder at -20°C or 4°C; in solvent at -80°C or -20°C.