Isotopically Labeled Compounds
Medchemexpress LLC Tropicamide-d3 | 2673270-13-6 | 99.10% | 1 MG
Tropicamide-d3 is a deuterium labeled Tropicamide and a selective M4 muscarinic acetylcholine receptor antagonist. It produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules as tracers for quantitation during drug development. Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Benzyl benzoate-d12 | 352431-26-6 | 99.9% | 5 MG
Benzyl benzoate-d12 is a deuterium-labeled form of Benzyl benzoate, also known as Benzoic acid benzyl ester-d12. It serves as a fragrance ingredient in cosmetic products and is utilized in research for Scabies and Demodex-associated inflammatory skin conditions. It is for research use only and not sold to patients. Deuteration, the incorporation of stable heavy isotopes of hydrogen, carbon, and other elements, is a key feature, offering potential benefits by affecting the pharmacokinetic and metabolic profiles of drugs during development.
- Used as a fragrance ingredient in cosmetic products.
- Utilized in research for Scabies and Demodex-associated inflammatory skin conditions.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration affects the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Fenoterol-d6 (hydrobromide) | 1286129-04-1 | 98.0% | 1 MG
Fenoterol-d6 hydrobromide is the deuterium-labeled version of Fenoterol hydrobromide, a sympathomimetic agent and selective β2-adrenoceptor agonist. It functions as an effective bronchodilator in research contexts, particularly for bronchospasm linked to asthma, bronchitis, and other obstructive airway diseases. This compound is also suitable for use as a tracer and internal standard in quantitative analysis methods such as NMR, GC-MS, or LC-MS.
- Deuterium-labeled version of Fenoterol hydrobromide
- Acts as a selective and orally active β2-adrenoceptor agonist
- Effective bronchodilator for research on bronchospasm associated with respiratory diseases
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-d7 | 1392208-04-6 | 99.6% | 1 MG
(Rac)-Ropivacaine-d7 is a stable isotope-labeled compound, identified as 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-d7. It appears as a white to off-white solid with an isotopic enrichment of 99.11%. This product is intended for research use only and should be handled by qualified personnel in appropriately equipped facilities.
- High purity of 99.6% (HPLC)
- Stable under recommended storage conditions
- Ideal for laboratory chemical applications and substance manufacturing
- For research use only
Medchemexpress LLC Benzene-2,3,5,6-d4-sulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)- | 1020719-86-1 | 99.3% | 5 MG
Sulfamethoxazole-d4 (Ro 4-2130-d4) is a deuterium-labeled version of Sulfamethoxazole, a sulfonamide antibiotic with broad antibacterial activity. It inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (PABA) to affect dihydropteroate synthetase and dihydropteroate reductase. This compound is used in research for conditions such as urinary tract infections (UTIs), prostatitis, and bronchitis. Deuterium labeling incorporates stable heavy isotopes into the drug molecule, which can serve as a tracer for quantitation during drug development and potentially affect pharmacokinetic and metabolic profiles.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Lamotrigine-d3 | 1132746-94-1 | 1 MG
Lamotrigine-d3 is the deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. It selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, among others. It is intended for research use only. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Etidronic acid-d3 disodium | 358730-93-5 | 98.0% | 1 MG
Etidronic acid-d3 disodium is a deuterium labeled compound, serving as a stable isotope-labeled compound.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Deuteration has potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Tetrabenazine-d6 | 1392826-25-3 | 98.2% | 5 MG
Tetrabenazine-d6 (Deutetrabenazine) is a deuterium-labeled Tetrabenazine, which is the first deuterium approved worldwide for the research of Huntington's disease, or other hyperkinetic movement disorders.
- Extend the half-life in vivo.
- Improve oral bioavailability.
- Improve metabolic characteristics.
- Improve drug safety.
- Preserve the therapeutic properties.
Medchemexpress LLC Creatinine-13C | 1173022-95-1 | >99.9% | 5 MG
Creatinine-13C is the 13C-labeled Creatinine, a breakdown product of creatine phosphate in muscle that is usually produced at a fairly constant rate by the body. This product is intended for research use only and serves as a valuable tool in various analytical and research applications due to its stable heavy isotope label. It is particularly useful for precise quantitative analysis in studies involving pharmacokinetics and metabolic profiling.
- Used as a tracer in research studies.
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of carbon for drug development processes.
- Can influence pharmacokinetic and metabolic profiles of drugs.
- Molecular formula is C313CH7N3O.
Medchemexpress LLC (R)-Amlodipine-d4 | 1346616-97-4 | 500 UG
(R)-Amlodipine-d4 is a deuterium-labeled form of (R)-Amlodipine. Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for use as tracers in drug development for quantitation. Deuteration has gained attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labeled form of (R)-Amlodipine
- Stable heavy isotopes for use as tracers
- Potential to influence pharmacokinetic and metabolic profiles of drugs
Sigma Aldrich Fine Chemicals Biosciences L-Valine-d8 >=98 atom % D, >=98% (CP) | 35045-72-8 | MFCD00144704 | 1G
L-Valine-d8 >=98 atom % D, >=98% (CP) | Purity: >=98% (CP) | Mol Wt: 125.2 | 35045-72-8 | MFCD00144704 | 1G
Medchemexpress LLC L-Ascorbic acid-13C-2 | 1313730-17-4 | 95.0% | 5 MG
L-Ascorbic acid-13C-2 is the 13C labeled L-Ascorbic acid, an electron donor and endogenous antioxidant agent. It inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM and is also a collagen. This compound is useful in various analytical applications.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Monoolein-d7 | 2260669-49-4 | ≥99.0% | 1 MG
Monoolein-d7 is deuterium labeled Monoolein, functioning as an endogenous metabolite. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily serving as tracers for quantitation during the drug development process. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled monoolein
- Functions as an endogenous metabolite
- Used as tracers for quantitation in drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Purity of 99.0% or greater
- Recommended storage condition: solution at -20°C for up to 2 years
Medchemexpress LLC Ceftazidime-d5 (GR20263-d5) | 93.7% | 1 MG
Ceftazidime-d5 (GR20263-d5) is a deuterium-labeled antibiotic, specifically a version of Ceftazidime. Ceftazidime exhibits broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria, including Enterobacteriaceae (even β-lactamase-positive strains), and resists hydrolysis by most β-lactamases. Deuterium-labeled compounds, such as Ceftazidime-d5, are used as tracers for quantitative analysis during drug development, impacting pharmacokinetic and metabolic profiles.
- Deuterium-labeled version of Ceftazidime
- Exhibits broad-spectrum antibiotic activity
- Effective against Gram-positive and Gram-negative aerobic bacteria
- Active against Enterobacteriaceae, including β-lactamase-positive strains
- Resistant to hydrolysis by most β-lactamases
- Useful as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Benzyl benzoate-d5 | 347840-01-1 | 99.8% | 50 MG
Benzyl benzoate-d5 is a deuterium-labeled form of Benzyl benzoate. Benzyl benzoate (benzoic acid benzyl ester) is used as a fragrance ingredient in cosmetic products and in research related to scabies and demodex-associated inflammatory skin conditions. It is for research use only.
- Deuterium-labeled compound
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, or LC-MS techniques
- Potential to influence pharmacokinetic and metabolic profiles of drugs