Isotopically Labeled Compounds
Medchemexpress LLC Desvenlafaxine-d6 | 1062605-69-9 | 1 MG
Desvenlafaxine-d6 is deuterium labeled Desvenlafaxine, an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor. It shows weak binding affinity at the human dopamine (DA) transporter. Deuterated compounds like Desvenlafaxine-d6 are used as tracers for quantitation during drug development due to their potential to affect pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Clomipramine-d6 hydrochloride | 1189882-28-7 | 1 MG
Clomipramine-d6 hydrochloride is a deuterium labeled form of Clomipramine hydrochloride, a potent 5-HT reuptake blocker with an IC50 value of 1.5 nM. It is a tricyclic antidepressant used in research for depression and obsessive compulsive disorder (OCD). Deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
- Suitable for research of depression and obsessive compulsive disorder (OCD).
Cayman Chemical GlycocholIc AcId-d4 1mg
An internal standard for the quantification of glycocholic acid by GC- or LC-MS
Medchemexpress LLC Adenosine-d13 | 58-61-7 | 96.6% | 5 MG
Adenosine-d13 is a deuterium-labeled form of Adenosine, an endogenous autacoid crucial for various cellular processes. It interacts with G protein-coupled receptors (A1, A2A, A2B, and A3) and plays a role in neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Used as a tracer
- Can serve as an internal standard for quantitative analysis
- Suitable for analysis techniques such as NMR, GC-MS, or LC-MS
Medchemexpress LLC (S)-Lathosterol-d4 | 1182005-25-9 | 99.7% | 390.68 | 1 MG
(S)-Lathosterol-d4 is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule, and serum Lathosterol concentration indicates whole-body cholesterol synthesis.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Amlodipine-d4 (maleate) | 2714486-25-4 | 98.2% | 5 MG
Amlodipine-d4 (maleate) is the deuterium-labeled Amlodipine maleate, a dihydropyridine calcium channel blocker. It functions as an orally active antianginal agent by blocking voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. This compound is valuable for research into high blood pressure and cancer.
- Functions as a tracer in drug development processes.
- Serves as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Aids in the study of high blood pressure and cancer.
- Offers potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Valine-2,3,4,4,4,4',4',4'-d8 | 203784-63-8 | MFCD00144194 | 125.20 | 10 MG
DL-Valine-d8 is the deuterium labeled DL-Valine. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Pimozide-d4 | 1803193-57-8 | 99.2% | 1 MG
Pimozide-d4 is a deuterium labeled Pimozide. It acts as a dopamine receptor antagonist with Ki values of 1.4 nM, 2.5 nM, and 588 nM for dopamine D2, D3, and D1 receptors, respectively. It also has an affinity at α1-adrenoceptor with a Ki of 39 nM, and inhibits STAT3 and STAT5. This compound can be used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled compound
- Dopamine receptor antagonist (D2, D3, D1)
- Affinity at α1-adrenoceptor
- Inhibits STAT3 and STAT5
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Cephalexin-d5 | 2101505-56-8 | 98.96% | 5 MG
Cephalexin-d5 is deuterium labeled Cephalexin. Cephalexin is a potent, orally active, first-generation cephalosporin antibiotic. It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, among other conditions. Deuterium substitution can impact the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Ketotifen-d3 fumarate | 1795138-23-6 | 99.2% | 1 MG
Ketotifen-d3 (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks. It is for research use only and not sold to patients.
- Deuterium labeled Ketotifen fumarate
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Ambroxol-d5 (hydrochloride) | 2741380-71-0 | 99.6% | 500 UG
Ambroxol-d5 (hydrochloride) is the deuterium-labeled Ambroxol hydrochloride. Ambroxol hydrochloride, an active metabolite of the proagent Bromhexine, has potent expectorant effects. It acts as a glucocerebrosidase (GCase) chaperone, increasing glucocerebrosidase activity and inducing lung autophagy. It has potential for Parkinson's disease and neuronopathic Gaucher disease research.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Galanthamine-d6 | 1128109-00-1 | MFCD28138526 | 99.5% | 293.39 | C17H15D6NO3 | 10 MG
Galanthamine-d6 is the deuterium-labeled analogue of galanthamine, a potent acetylcholinesterase (AChE) inhibitor. The compound is intended for research use and serves as an analytical standard or internal standard for quantitative analysis techniques such as NMR, GC-MS, and LC-MS.
- Deuterium-d6 labeled galanthamine for isotope tracing and analytical standard use.
- High isotopic and chemical purity (reported ~99.5%).
- Appropriate as an internal standard for NMR, GC-MS, and LC-MS quantitation.
- Available in small sizes for analytical workflows (10 mg available).
- Solid, white to yellow appearance; powder storage recommended at -20°C for long-term stability; solvent samples require lower temperatures.
Medchemexpress LLC Squalane-d62 | 16514-83-3 | 100 MG
Squalane-d62 is the deuterium-labeled version of Squalane, a saturated derivative of Squalene found in certain fish and vegetable oils. It exhibits anticancer, antioxidant, skin hydrating, and emollient activities.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Rabeprazole-d4 sodium | 117976-90-6 | 98.6% | 385.45 | C18H16D4N3NaO3S | 10 MG
Rabeprazole-d4 sodium is the deuterium-labeled sodium salt of rabeprazole, supplied as a stable isotope internal standard for analytical assays. It is intended for quantitative mass spectrometry and other analytical methods that require an isotopically labeled reference.
- Deuterium-labeled internal standard for LC-MS quantification.
- High chemical purity for reliable analytical performance.
- Suitable for pharmacokinetic and bioanalytical method development.
- Supplied in a small-mass package for trace-level studies.
- Stable under recommended storage conditions.
Cambridge Isotope Laboratories CYCLOPENTYL BROMIDE-D9 (D, 99%), 1 G, 35468-44-1
CYCLOPENTYL BROMIDE-D9 (D, 99%), 1 G, 35468-44-1
