Custom Rearray cDNAs, shRNAs, siRNAs, and PCR Probes

R&D Systems™ VersaClone cDNA, Human GlyT2/SLC6A5 (NP_004202)

SLC6A5 is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses

R&D Systems™ Human TfR2 (NP_003218) VersaClone cDNA

HFE3 transferrin receptor protein 2

R&D Systems™ VersaClone cDNA, Mouse PDGF R beta (NP_032835)

PDGFRB plays a novel role in the progression of many vascular diseases

R&D Systems™ VersaClone cDNA, Human IL-12 R beta 1 (NP_005526)

IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35

R&D Systems™ VersaClone cDNA, Human CLCA2 (NP_006527)

CLCA2 plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner

R&D Systems™ Mouse Apolipoprotein E R2/ApoE R2 (Q924X6) VersaClone cDNA

APOER2HSZ75190; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8

R&D Systems™ VersaClone cDNA, Mouse B7-H4 (NP_848709)

High levels of B7-H4 expression have been correlated with tumor progression. It may serve as a predictive marker for renal cell carcinoma

R&D Systems™ VersaClone cDNA, Mouse FATP4 (NP_036119)

Fatty Acid Transport Protein 4. This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation.

R&D Systems™ VersaClone cDNA, Human B7-H3 (NP_079516)

B7-H3 has been shown to be expressed at very high levels in immature dendritic cells, at moderate levels on mature dendritic cells, LPS stimulated immature dendritic cells and LPS stimulated monocytes, and at low levels on resting monocytes.

R&D Systems™ Human ROR1 (NP_005003) VersaClone cDNA

MGC99659; neurotrophic tyrosine kinase receptor-related 1

R&D Systems™ Mouse CEACAM-2 (NP_001106839) VersaClone cDNA

Carcinoembryonic Antigen-related Cell Adhesion Molecule 2

R&D Systems™ VersaClone cDNA, Human Siglec-16 (A6NMB1)

Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of pathogens.

R&D Systems™ VersaClone cDNA, Mouse BMPR-IA/ALK-3 (NP_033888)

BMPR1A is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-β family cytokines

R&D Systems™ VersaClone cDNA, Mouse TACI/TNFRSF13B (NP_067324)

TACI may play an important role in B cell development, function, and regulation.

R&D Systems™ Human B7-H7/HHLA2 (NP_009003) VersaClone cDNA

HERV-H LTR-associating 2; HERV-H LTR-associating protein 2

R&D Systems™ VersaClone cDNA, Mouse Axl (NP_033491)

AXL is involved in the stimulation of cell proliferation and can mediate cell aggregation by homophilic binding

R&D Systems™ VersaClone cDNA, Human Common beta Chain (NP_000386)

Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells

R&D Systems™ Mouse IL-23 R (NP_653131) VersaClone cDNA

IL-23 receptor; IL-23R; interleukin 23 receptor; interleukin-23 receptor

R&D Systems™ VersaClone cDNA, Mouse Integrin alpha 2/CD49b (NP_032422)

Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions

R&D Systems™ Mouse IL-31 RA (AAM27959) VersaClone cDNA

Class I cytokine receptor; CRL3Glmr; Cytokine receptor-like 3; GLMR; GLM-RMGC125346