Lipids and Lipid Derivatives
Medchemexpress LLC Monomethyl auristatin E intermediate-1 | 120205-48-3 | 99.5% | 295.85 | 5 G
Monomethyl auristatin E intermediate-1 is an intermediate reagent used in the synthesis of Monomethyl auristatin E (MMAE). MMAE is a microtubule/tubulin inhibitor with anticancer activity, and it is widely utilized as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs). This product is for research use only and not for sale to patients.
- Appearance: Solid
- Color: White to off-white
- Formula: C14H30ClNO3
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, stored under nitrogen, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (stored under nitrogen, away from moisture).
Medchemexpress LLC Isocitric acid (Standard) | 320-77-4 | 99.9% | 192.12 | 50 MG
Isocitric acid (Standard) is the analytical standard of Isocitric acid. This product is intended for research and analytical applications. Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia. For research use only.
- The compound is an analytical standard, which is the reference standard supplied assay.
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Medchemexpress LLC Phorbol 12-myristate 13-acetate | 16561-29-8 | 99.8% | 616.83 | 25 MG
Phorbol 12-myristate 13-acetate (PMA) is a phorbol ester and a dual SphK and protein kinase C (PKC) activator. It also acts as an NF-κB activator and induces differentiation in THP-1 cells. This product is intended for research and analytical applications, and extreme caution is advised when handling due to its potent tumor-promoting properties.
- Functions as a dual SphK and protein kinase C (PKC) activator.
- Acts as an NF-κB activator.
- Induces differentiation in THP-1 cells.
- Suitable for research and analytical applications.
- Can be used to create models of ear edema in vivo.
Selleck Chemical LLC Solifenacin succinate S3048-10mg
Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class
Medchemexpress LLC Zinc stearate 100g
Zinc stearate is a Zinc distearate Zinc stearate can be used as an excipient such as lubricants for tablets and capsules Pharmaceutical excipients or pharmaceutical auxiliaries refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations which can improve the stability solubility and processability of pharmaceutical preparations Pharmaceutical excipients also affect the absorption distribution metabolism and elimination (ADME) processes of co-administered drugs[1][2]
eMolecules Chem-Impex Lauric acid 5kg 603112295 34486 0 000 143-07-7 MFCD00002736 200 322 C12H24O2
Chem-Impex Lauric acid 5kg 603112295 34486 0 000 143-07-7 MFCD00002736 200 322 C12H24O2
Medchemexpress LLC Hexadecanoic acid, methyl ester | 112-39-0 | 270.45 | 1 G
Methyl palmitate is a naturally occurring fatty acid ester that acts as a potent inhibitor of IκB phosphorylation. It modulates macrophage activity to down-regulate pro-inflammatory mediators such as TNF-α and nitric oxide (NO), exhibiting anti-inflammatory and antifibrotic effects. It can inhibit LPS-induced Kupffer cells and rat peritoneal macrophages, as well as the phagocytic function of RAW cells. This compound is also antagonistic to muscarinic receptors and provides cardioprotective effects against ischemia/reperfusion injury in vivo. It is highly toxic against adult T. cinnabarinus.
- Naturally occurring fatty acid ester
- Potent inhibitor of IκB phosphorylation
- Modulates macrophage activity
- Down-regulates pro-inflammatory mediators
- Anti-inflammatory and antifibrotic effects
- Antagonistic to muscarinic receptors
- Cardioprotective effects
Medchemexpress LLC Procyanidin B2 | 29106-49-8 | 578.52 | 25 MG
Procyanidin B2 is a natural flavonoid known for its anti-cancer and antioxidant properties, making it valuable for various research applications. It is intended for research use only.
- Exhibits antiproliferative activity in MCF-7 cells.
- Inhibits NLRP3 inflammasome activation in human umbilical vein ECs (HUVECs).
- Reduces reactive oxygen species (ROS).
- Protects against cerebral ischemia-induced infarct volume and brain edema.
- Improves neurological functional outcomes and regulates blood-brain barrier permeability.
- Attenuates cerebral ischemia-induced tight junction degradation, mitochondrial depolarization, and intracellular oxidative stress.
- Increases Nrf2 activation and expression of HO-1, GSTα, and NQO1 proteins.
Medchemexpress LLC Itaconate-alkyne | 2454181-83-8 | 98.0% | C13H18O4 | 10MG
Itaconate-alkyne is an alkyne-tagged bioorthogonal probe designed for quantitative and site-specific chemoproteomic profiling of itaconation in living cells. As a functional analogue of itaconate, it enables labeling of bona fide itaconate targets and is compatible with click-chemistry workflows.
- Contains alkyne group for copper-catalyzed azide-alkyne cycloaddition.
- Enables quantitative and site-specific chemoproteomic profiling.
- Functions as a structural analogue of itaconate with comparable anti-inflammatory effects.
- High purity solid form for reliable experimental results.
- Available in multiple small-scale packaging sizes suitable for laboratory use.
- Compatible with standard click-chemistry reagents and protocols.
Medchemexpress LLC Methyl myristate | 124-10-7 | 242.40 | 5 G
Methyl myristate is a saturated fatty acid methyl ester produced through the esterification of myristic acid. It has been observed to exhibit a high melanin induction in B16F10 melanoma cells.
- In vitro activity: Methyl myristate is a component of petroleum ether extract.
- This extract has demonstrated the ability to reduce acetylcholine and ergot alkaloid-induced uterine contractions in isolated rat uteri, indicating uterine relaxation activity.
eMolecules 37779-49-0 | 3-Oxo-4-phenylbutyric acid methyl ester | Combi-Blocks | MFCD03424746 | 192.214 | C11H12O3 | 98.000 | COC(=O)CC(=O)Cc1ccccc1 | 25g | 296395714
3-Oxo-4-phenylbutyric acid methyl ester | Combi-Blocks | 37779-49-0 | MFCD03424746 | 192.214 | C11H12O3 | 98.000 | COC(=O)CC(=O)Cc1ccccc1 | 25g | 296395714
Cayman Chemical Betamethason 17-valerate 500mg
A glucocorticoid with anti-inflammatory activity; inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively); topical application of a 0.12% ointment blocks increases in EAr weight in a rat model of EAr edema induced by croton oil
Medchemexpress LLC Mk-0812 succinate | 851916-42-2 | 99.94% | C28H40F3N3O7 | 100 MG
MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity. It completely blocks all MCP-1 mediated responses in a concentration-dependent manner. It also inhibits 125I-MCP-1 binding on isolated monocytes. The compound blocks the shape change response to exogenous MCP-1 and reduces the frequency of Ly6G-Ly6Chi monocytes in peripheral blood in vivo.
- Potent and selective CCR2 antagonist
- High affinity at CCR2
- Blocks all MCP-1 mediated responses
- Inhibits 125I-MCP-1 binding on isolated monocytes
- Reduces Ly6G-Ly6Chi monocytes in peripheral blood in vivo