Chromatography Standards
Apexbio Technology LLC Atovaquone(Synonyms: Mepron, Wellvone, 566C80, BW 566C, Atavaquone, Hydroxy-1,4-naphthoquinone derivative), 50mg, CAS: 95233-18-4.
Atovaquone (CAS 95233-18-4) is a hydroxynaphthoquinone compound employed in biomedical research primarily due to its inhibitory action against mitochondrial electron transport in pathogenic microorganisms Specifically it targets cytochrome bc1 complex (complex III) disrupting mitochondrial respiration and consequently impairing pyrimidine biosynthesis and replication in parasites This mechanism underlies its research utility in studying parasite metabolism and antiprotozoal therapeutics notably concerning Pneumocystis jirovecii pneumonia toxoplasmosis malaria and babesiosis
Medchemexpress LLC Tofacitinib impurity 4 | 384338-23-2 | 96.0% | 218.34 | 50 MG
Tofacitinib impurity 4 is an impurity of Tofacitinib. This product is designed for research use only.
- Appearance: Liquid
- Color: Colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Pure form can be stored at -20°C for 3 years or 4°C for 2 years; in solvent, it can be stored at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Palbociclib impurity 20 | 1774898-55-3 | 99.9% | 308.34 | 5 MG
Palbociclib impurity 20 is an impurity of Palbociclib (HY-50767). It has a CAS No. of 1774898-55-3 and a Molecular Weight of 308.34. The chemical formula is C14H20N4O4 and it appears as a solid.
- High purity for reliable research
- Shipped at room temperature in continental US
- Powder can be stored at -20°C for 3 years or 4°C for 2 years
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Rebamipide impurity 13 | 4876-17-9 | MFCD22194962 | 698.0% | 193.63 | C10H8ClNO | 50 MG
Rebamipide impurity 13 is supplied for research use as a drug intermediate and chemical impurity of rebamipide. It is provided as a stable powder with recommended cold storage and is intended for laboratory studies of impurity profiling, synthesis, and analytical method development.
- Intended use: drug intermediate and impurity studies.
- CAS number: 4876-17-9.
- Molecular formula: C10H8ClNO.
- Molecular weight: 193.63 g/mol.
- Purity: ≥98.0%.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
Cayman Chemical Temozolomide, Purity: ≥98%, CAS: 85622-93-1, 25 mg
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
Medchemexpress LLC Berberine hemisulfate | 316-41-6 | 384.40 | 1 G
Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. This compound demonstrates anti-inflammatory, antibiobic, antitumor, cardiovascular protective, and neuroprotective activities, and is intended for research use only.
- Exhibits antimicrobial activity by inhibiting cell division protein FtsZ or through DNA/RNA binding.
- Shows anti-inflammatory activity by inhibiting TNF-α and its downstream pathways AP-1 and NF-kB.
- Provides neuroprotective efficacy by inhibiting reactive oxygen species (ROS) production and caspase activation.
- Attenuates metabolic diseases by regulating lipid composition and inhibiting insulin resistance.
Cayman Chemical 5-trans Latanoprost (free acid), Purity: ≥95%, CAS: 903549-49-5, 1 mg
An isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E); intended primarily as an analytical standard
Medchemexpress LLC Mifepristone | 84371-65-3 | 99.9% | 429.59 | 1 ML
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. It was discovered as the first competitive progesterone antagonist, stimulating a search for more potent and selective antiprogestins.
- Progesterone receptor and glucocorticoid receptor antagonist
- Inhibits cell growth
- Potentiates doxorubicin-induced cytotoxicity in K562/R7 cells
- Reduces severity of EtOH withdrawal in vivo
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 1 ML
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission. It is supplied as a solid, white to off-white powder.
- Antipsychotic and dopamine receptor D2 antagonist
- Inhibits dopaminergic neurotransmission
- Shows KDs of 25, 190, and 8400 nM at human norepinephrine, serotonin, and dopamine transporters
- Molecular weight: 320.88
- Chemical formula: C17H21ClN2S
- Soluble in water and DMSO at 100 mg/mL
Apexbio Technology LLC Fostamatinib (R788) 901119-35-5 100mg
Fostamatinib (R788 CAS 901119-35-5) is an orally available small-molecule inhibitor targeting spleen tyrosine kinase (Syk) with an IC50 of approximately 41 nM As a prodrug fostamatinib is rapidly converted to its active metabolite R406 an ATP-competitive inhibitor of Syk (Ki 30 nM) R406 additionally inhibits related kinases such as Flt3 Lyn (IC50 63 nM) and Lck (IC50 37 nM) thereby modulating BCR- and Fc receptor-mediated signaling pathways Preclinical studies demonstrate activity of fostamatinib in various autoimmune and inflammatory models including SLE-related nephritis and dermatitis in MRL/lpr mice highlighting its utility as a research tool in autoimmune disease investigation
Medchemexpress LLC Oxibendazole | 20559-55-1 | 99.6% | 25 MG
Oxibendazole is an effective benzimidazole anthelmintic that combats nematode infections. It has demonstrated the ability to induce apoptosis and exhibits both anti-cancer and anti-inflammation activities.
- Induces apoptosis
- Active against nematode infections
- Exhibits anti-cancer activities
- Possesses anti-inflammation properties
- Downregulates phosphorylation of ERK1/2, P90RSK, and S6
- Upregulates expression of phosphorylated JNK, AKT, and P70S6K
Medchemexpress LLC Glipizide (Standard) | 29094-61-9 | 99.7% | 25 MG
Glipizide (Standard) is an analytical standard of Glipizide, intended for research and analytical applications. It is a potent, orally active sulfonylurea class anti-diabetic agent used for type 2 diabetes mellitus research.
- Potent, orally active sulfonylurea class anti-diabetic agent
- Used for type 2 diabetes mellitus research
- Acts by partially blocking ATP-sensitive potassium (KATP) channels
- Suitable for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- IC50: 6.4 nM ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells
Medchemexpress LLC Clopidogrel-related Compound B (hydrochloride) | 144750-52-7 | 99.7% | 358.28 | 50 MG
Clopidogrel-related Compound B hydrochloride is an impurity of Clopidogrel. It is a solid with a white to yellow appearance, typically used for laboratory research.
- High purity at 99.67%
- Molecular weight of 358.28
- Chemical formula is C16H17Cl2NO2S
- Identified by CAS number 144750-52-7
Medchemexpress LLC Naphazoline hydrochloride | 550-99-2 | 99.4% | 5 G
Naphazoline hydrochloride is a potent α-adrenergic receptor agonist. It reduces vascular hyperpermeability and promotes vasoconstriction. This compound also decreases the levels of inflammatory factors (TNF-α, IL-1β, IL-6), cytokines (IFN-γ, IL-4), IgE, GMCSF, and NGF. It is used in research for non-bacterial conjunctivitis.
- Reduces vascular hyperpermeability
- Promotes vasoconstriction
- Decreases inflammatory factors (TNF-α, IL-1β, IL-6)
- Decreases cytokines (IFN-γ, IL-4)
- Decreases IgE, GMCSF, and NGF levels
- Used in research for non-bacterial conjunctivitis
Medchemexpress LLC Alverine citrate | 5560-59-8 | 99.5% | 10 MM 1 ML
Alverine citrate is a 5-HT1A receptor antagonist with an IC50 of 101 nM, primarily used for research and analytical applications. It acts directly on gut muscles, causing relaxation, and is used in studies of functional gastrointestinal disorders. This compound shows high affinity for 5-HT1A receptors and weak affinity for 5-HT3 and 5-HT4 subtypes.
- 5-HT1A receptor antagonist
- IC50 of 101 nM
- Used for research and analytical applications
- Relaxes gut muscles
- High affinity for 5-HT1A receptors
- Molecular formula: C26H35NO7
- Molecular weight: 473.56
- Appearance: White to off-white solid