Sugar acids and derivatives
Medchemexpress LLC D-Biotinol 25mg
D-Biotinol is the nutrition of Lactobacillus arabinosus L casei or Saccharomyces cerevisiae D-Biotinol replaces the D-biotin (HY-B0511) in saving egg white induced biotin deficiency in rats D-Biotinol is orally active and displays to be converted to biotin by rats[1]
Medchemexpress LLC β-D-glucopyranosiduronic acid p-nitrophenyl carbonate derivative | 894095-98-8 | 99.6% | 913.83 g/mol | C45H43N3O18 | 1 G
β-D-glucuronide-pNP-carbonate is a glucuronide-cleavable carbonate linker used to attach payloads to antibodies for research-scale antibody-drug conjugate (ADC) synthesis. It is supplied as a purified small-molecule reagent for linker-payload assembly and analytical characterization.
- Cleavable glucuronide-based linker responsive to glycosidase cleavage.
- Reported purity around 99.6%.
- Molecular formula C45H43N3O18; molecular weight 913.83 g/mol.
- Available in small-scale packaging including 1 G; larger quantities available on request.
- Supporting documents include datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside | 37067-30-4 | 99.95% | 379.36 | 1 ML
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase. The enzyme functionality is assessed by its ability to remove terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from this compound. This product is supplied as a 10 mM solution in 1 mL of DMSO, ready for reconstitution. For optimal stability, the solution should be stored at 4°C, protected from light. Once in solvent, store at -80°C for up to 6 months or -20°C for 1 month, also protected from light.
- Fluorogenic substrate for N-acetyl-β-D-glucosaminidase
- Assesses enzyme functionality by removing terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues
- Can be prepared in DMSO at 50 mg/mL (131.80 mM)
- Requires ultrasonication for preparation
- Newly opened DMSO is recommended due to hygroscopic nature affecting solubility
Medchemexpress LLC d-KLA Peptide | 286380-05-0 | >99.3% | 1523.99 | 10 MG
d-KLA Peptide is a synthetic pro-apoptotic peptide that specifically targets mitochondria. It induces apoptosis by destroying the mitochondrial membrane and activating associated biochemical pathways, including caspase family proteins and PARP. This peptide can also be utilized to carry and deliver genes or small molecules, enhancing anti-tumor effects.
- Specifically targets mitochondria
- Induces apoptosis by destroying mitochondrial membrane
- Activates caspase family proteins and PARP
- Can deliver genes or small molecules to enhance anti-tumor effects
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | MFCD00872153 | 99.9% | 568.53 | C28H28N2O11 | 5 MG
SN-38 glucuronide is the glucuronidated, inactive metabolite of the anticancer agent irinotecan, supplied for research use to study drug metabolism, pharmacokinetics, and cellular resistance mechanisms. The substance is characterized by CAS 121080-63-5, molecular formula C28H28N2O11, and molecular weight 568.53.
- High purity suitable for analytical and biological studies.
- Useful for metabolism and pharmacokinetic assays.
- Enables investigation of cellular resistance to SN-38.
- Suitable as a reference standard for LC-MS/MS and HPLC methods.
- Provided in defined small-mass pack sizes for laboratory use.
Medchemexpress LLC Garcinone D | 107390-08-9 | 25 MG
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways and an inhibitor of CDK2/CyclinE1. It promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression, and by enhancing the Nrf2/HO-1 signaling pathway. Additionally, it blocks the tumor cell cycle by inhibiting CDK2/CyclinE1.
- Activates STAT3/Cyclin D1 and Nrf2/HO-1 pathways
- Inhibits CDK2/CyclinE1 (IC50 is 28.23 μM)
- Promotes neural stem cell proliferation
- Blocks tumor cell cycle
- Can inhibit prostate and breast cancer
Medchemexpress LLC 4-methylumbelliferyl α-L-arabinofuranoside | 77471-44-4 | MFCD00057308 | 99.9% | 308.28 | C15H16O7 | 5 MG
4-Methylumbelliferyl α-L-arabinofuranoside is a fluorogenic glycosidase substrate used to measure α-L-arabinofuranosidase activity. Enzymatic hydrolysis releases fluorescent 4-methylumbelliferone, enabling sensitive fluorometric assays in biochemical and enzymology workflows. For research use only.
- Fluorogenic substrate for α-L-arabinofuranosidase assays.
- Produces 4-methylumbelliferone for sensitive fluorometric detection.
- High purity (99.93%) to minimize background signal.
- Molecular weight 308.28 and formula C15H16O7.
- Soluble in DMSO at ≥ 50 mg/mL.
- White to off-white solid with recommended cold storage for stability.
- Supplied in small research pack sizes suitable for assay development.
Medchemexpress LLC Arnicolide D | 34532-68-8 | 10 MG
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. It demonstrates cytotoxicity against tumor cells, inducing cell cycle arrest, apoptosis, and oncosis. Arnicolide D exhibits anti-tumor activity.
- Antitumor agent: Is cytotoxic to tumor cells and has anti-tumor activity.
- Induces cell cycle arrest and apoptosis in nasopharyngeal carcinoma cells by activating the caspase signaling pathway and inhibiting the PI3K/AKT/mTOR and STAT3 signaling pathways.
- Induces endoplasmic reticulum stress-mediated and ROS-dependent oncosis in hepatocellular carcinoma cells via ATF4 and CHOP.
- Demonstrates anti-melanoma effects and inhibits the NF-κB pathway in an in vivo B16F10 allograft mouse model.
- High purity of 99.69%.
- Solid, white to off-white appearance.
Medchemexpress LLC Interferon alpha/beta receptor 1 Antibody (YA3833) | 110-130 kDa | 10 UL
This Interferon alpha/beta receptor 1 Antibody (YA3833) is a mouse-derived, non-conjugated IgG1 monoclonal antibody targeting Interferon alpha/beta receptor 1. It forms a heterodimeric receptor with IFNAR2 for type I interferons, activating the JAK-STAT signaling cascade to regulate interferon-responsive genes.
- Mouse-derived monoclonal antibody
- Non-conjugated IgG1 isotype
- Targets interferon alpha/beta receptor 1
- Reacts with human and mouse species
- Suitable for WB, IHC-P, FC, and ELISA applications
- Supplied as a liquid in PBS with 0.05% sodium azide
- Purity is affinity purified
- Store at -20°C for one year; avoid repeated freeze/thaw cycles
![Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy B D glucopyranoside [4 Methylumbelliferyl N acetyl B D glucosaminide], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660605.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy B D glucopyranoside [4 Methylumbelliferyl N acetyl B D glucosaminide], 1 G
Methylumbelliferyl N-acetylglucosaminide (1 g) is a fluorogenic substrate used in enzymatic assays, particularly for detecting the activity of β-glucosaminidases. This compound is widely used in research and diagnostic laboratories for assessing enzyme activity in microbial samples, tissue cultures, and various biochemical processes. The fluorogenic property of this substrate means it generates a detectable fluorescence when cleaved by the enzyme, providing a sensitive and reliable measurement. This 1 g quantity is ideal for routine laboratory assays where the activity of glycosidases, particularly in cell-based systems, is being studied.
Medchemexpress LLC Protac BET degrader-1 | 2093386-22-0 | 99.4% | 871.90 g/mol | C44H45N11O9 | 1 ML
PROTAC BET Degrader-1 is a proteolysis-targeting chimera that links a Cereblon ligand to a BET-family ligand to promote ubiquitination and proteasomal degradation of BET proteins BRD2, BRD3, and BRD4. It is used in biochemical and cellular assays to investigate BET protein degradation and downstream epigenetic effects.
- Induces selective degradation of BRD2, BRD3, and BRD4 at low nanomolar concentrations.
- Provided as a 10 mM solution in DMSO, 1 mL vial.
- High purity (99.4% by LCMS).
- Molecular formula C44H45N11O9; molecular weight 871.90 g/mol.
- Storage: powder -20°C for long term; in solvent -80°C recommended.
Medchemexpress LLC 6-(2-(2,4-Difluorophenoxy)-5-((ethylsulfonyl)methyl)pyridin-3-yl)-8-methylpyrrolo[1,2-a]pyrazin-1(2H)-one | 2411226-02-1 | 99.7% | 10 MM * 1 ML
BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. It binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). This inhibitor also demonstrates anti-cancer activity.
- Orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor.
- Binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities.
- Exhibits anti-cancer activity.
- Demonstrates antiproliferative activity against various human leukemia and myeloma cell lines.
- Induces G1-phase cell cycle arrest and reduces c-Myc, BCL-2, and CDK6 expressions in MV-4-11 cells.
- Offers high selectivity for the BET bromodomain family.
- Shows strong antitumor activities in an MV4-11 mouse xenograft model.
Medchemexpress LLC Tofogliflozin (hydrate) | 1201913-82-7 | MFCD27665464 | 98.4% | C22H28O7 | 10MG
Tofogliflozin hydrate is the monohydrate form of tofogliflozin, a potent and selective sodium-glucose cotransporter 2 (SGLT2) inhibitor supplied for research use in biochemical assays and preclinical diabetes studies.
- Potent and selective SGLT2 inhibition (IC50 ≈2.9 nM).
- Hydrated molecular form for consistent handling and characterization.
- High purity (~98.4%) suitable for research applications.
- Available in small-scale packages compatible with preclinical workflows.
- Soluble in common laboratory solvents such as DMSO and water for assay preparation.
Medchemexpress LLC Hederacoside D | 760961-03-3 | MFCD22572710 | 99.3% | 1075.24 | C53H86O22 | 10 MG
Hederacoside D is a bioactive triterpenoid saponin isolated from Hedera helix (common ivy). It is provided as a white to off-white solid for research and analytical applications, with high purity and characterized molecular properties. Solubility data indicate excellent solubility in DMSO and formulations suitable for in vivo dosing studies.
- Bioactive triterpenoid saponin from Hedera helix.
- High purity (99.3%).
- Molecular formula C53H86O22 and molecular weight 1075.24.
- Soluble in DMSO at 100 mg/mL (may require ultrasonic).
- Supplied in small research pack sizes such as 10 mg.
Medchemexpress LLC Bet bromodomain inhibitor | 1505453-59-7 | MFCD28144506 | 99.5% | 445.90 | C24H20ClN5O2 | 5 MG
BET bromodomain inhibitor (CAS 1505453-59-7) is a high-purity research compound that targets BET family bromodomains, with reported activity against BRD4 (IC50 = 14 nM). Supplied as a small solid pack for laboratory use, it is intended for in vitro and preclinical studies of epigenetic regulation and tumor cell biology.
- High purity (99.53%).
- Reported BRD4 potency: IC50 = 14 nM.
- Molecular formula C24H20ClN5O2; molecular weight 445.90.
- Supplied as a 5 mg solid suitable for assay development.
- Useful for epigenetic and tumor research applications.