Drug Standards
Medchemexpress LLC Lenalidomide-F | 2359705-88-5 | MFCD31556181 | 99.4% | 262.24 g/mol | C13H11FN2O3 | 250 MG
Lenalidomide-F is a research-grade cereblon E3 ligase ligand commonly used as the recruiting moiety in PROTAC molecules. It facilitates cereblon-mediated, proteasome-dependent degradation of target proteins and has been used in degraders reporting subnanomolar potency (DC50 ≈ 0.64 nM). It is supplied as a solid for biochemical and cellular research applications.
- E3 ligase ligand that recruits cereblon.
- Enables proteasome-dependent degradation when incorporated into PROTACs.
- Demonstrated FLT3 degradation with DC50 ≈ 0.64 nM.
- Reported high purity suitable for biochemical and cellular assays.
- Available in multiple pack sizes for research flexibility.
Medchemexpress LLC Lidocaine impurity 1 | 39084-88-3 | 99.9% | 232.11 | 25 MG
Lidocaine impurity 1 is an impurity of Lidocaine (HY-B0185). It is intended for research use only, and is not sold to patients.
- Information regarding specific features and benefits is not explicitly provided on the product page.
Apexbio Technology LLC ONX-0914 (PR-957) 960374-59-8 100mg
ONX-0914 (PR-957) is a selective inhibitor targeting the immunoproteasome subunit 5i (LMP7) a proteolytic component involved in antigenic peptide processing for MHC class I presentation By reversibly binding the 5i-specific catalytic pocket ONX-0914 impairs the production of pro-inflammatory cytokines in activated human peripheral blood mononuclear cells (PBMCs) and suppresses IL-17 secretion during Th17 cell differentiation ONX-0914 has been employed experimentally in preclinical models of autoimmune conditions such as arthritis colitis and diabetes Reported IC50 values are approximately 5 15 nM for the 5i subunit demonstrating selective preference over constitutive proteasome subunits
Medchemexpress LLC Isosorbide mononitrate | 16051-77-7 | 100.0% | 1 ML
Isosorbide mononitrate is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. It increases the viability and proliferation of HUVECs by decreasing apoptosis and elevating the expressions of vegf, kdrl, pdgfr in zebrafish embryos. It is promising for research of heart failure and coronary heart disease.
- Dilates blood vessels and lowers blood pressure
- Increases HUVECs viability and proliferation
- Decreases HUVECs apoptosis
- Elevates expressions of vegf, kdrl, and pdgfr in zebrafish embryos
- Inhibits angiogenesis, tumor growth, and metastasis
- Suitable for research of heart failure and coronary heart disease
Selleck Chemical LLC Flavopiridol (Alvocidib) HCl S2679-1g
Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1 CDK2 CDK4 and CDK6 with IC50 of 40 nM in cell-free assays It is 7 5-fold more selective for CDK1/2/4/6 than CDK7 Flavopiridol is initially found to inhibit EGFR and PKA Flavopiridol HCl induces autophagy and ER stress Flavopiridol HCl blocks HIV-1 replication Phase 1/2
TARGETMOL CHEMICALS INC Naftifine hydrochloride 1G
Also available in 1 mL, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride (Naftifine HCl) can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved. Purity 99.76%
Selleck Chemical LLC Triciribine 50mg 35943-35-2 NSC 154020, VD-0002, vqd-002, API-2
Triciribine (NSC 154020, VD-0002, vqd-002, API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Fluticasone propionate, 10mM (in 1mL DMSO)
Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
Medchemexpress LLC Milrinone | 78415-72-2 | 99.9% | C12H9N3O | 500 MG
Milrinone is a potent PDE3 inhibitor, also functioning as an inotrope and vasodilator. This product is intended for research use only and is not for patient administration.
- Potent PDE3 inhibitor
- Functions as an inotrope and vasodilator
- Appears as a solid, white to off-white powder
- Soluble in DMSO at 50 mg/mL
- Recommended storage for powder: -20°C for 3 years, 4°C for 2 years
- Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC (S)-Donepezil | 142057-80-5 | 99.8% | C24H29NO3 | 25 MG
(S)-Donepezil is the S-enantiomer of Donepezil, a specific and potent Acetylcholinesterase (AChE) inhibitor. It appears as a white to off-white solid and is intended for research use only.
- Specific and potent Acetylcholinesterase (AChE) inhibitor.
- Chemical formula: C24H29NO3.
- Molecular weight: 379.49.
- Soluble in DMSO (100 mg/mL).
- Recommended storage for powder: -20°C for 3 years or 4°C for 2 years.
- Recommended storage in solvent: -80°C for 6 months or -20°C for 1 month.
U.S. Pharmacopeia Lorazepam Related Compound D, 54643-79-7, MFCD06203519, 25 mg
Empirical Formula (Hill Notation): C15H8Cl2N2O2, Molecular Weight: 319.14, Synonym: 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid.
Medchemexpress LLC Flutrimazole | 119006-77-8 | MFCD00865591 | 99.3% | 346.37 | C22H16F2N2 | 5 MG
Flutrimazole is an imidazole antifungal analytical standard (CAS 119006-77-8) used in research and analytical applications. It shows dual anti-inflammatory and antifungal activity, limited transdermal penetration, and is supplied as a high-purity solid suitable for chromatographic and mass spectrometry methods.
- High purity (99.3%) for reliable analytical results.
- Suitable for HPLC, GC, and MS method development and validation.
- Dual anti-inflammatory and antifungal profile useful for topical infection studies.
- Limited transdermal penetration reduces systemic absorption concerns in dermal models.
- Available in small sample sizes for analytical testing, such as 5 mg.
Medchemexpress LLC Clevudine | 163252-36-6 | 99.84% | 260.22 | 100 MG
Clevudine (L-FMAU) is a nucleoside analog of the unnatural L-configuration, exhibiting potent anti-HBV activity with a long half-life and low toxicity. It acts as a non-competitive inhibitor by binding to the polymerase rather than being incorporated into the viral DNA. This compound is also effective against cowpox virus respiratory infection in mice and shows activity against Epstein-Barr virus.
- Nucleoside analog with L-configuration
- Potent anti-HBV activity
- Long half-life and low toxicity
- Non-competitive inhibitor; binds to polymerase
- Effective against cowpox virus respiratory infection
- Shows activity against Epstein-Barr virus
- White to off-white solid appearance
Medchemexpress LLC Desacetyl bisacodyl | 603-41-8 | MFCD00023496 | 99.0% | C18H15NO2 | 10MG
Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl, provided as a high-purity white to off-white solid for laboratory research. It has formula C18H15NO2 and a molecular weight of 277.32 g/mol. The compound is offered in small milligram pack sizes and includes guidance for cold-chain storage to preserve stability.
- Active metabolite of bisacodyl.
- High purity (99.0%).
- White to off-white solid physical form.
- Molecular formula C18H15NO2; MW 277.32 g/mol.
- Available in small milligram pack sizes for research use.
- Storage: 4°C under nitrogen; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Sofosbuvir impurity F | 1337482-17-3 | 98.5% | 798.69 g/mol | C34H45FN4O13P2 | 10 MG
Sofosbuvir impurity F is a diastereoisomer and analytical reference impurity of the antiviral sofosbuvir, supplied as a light-yellow solid for research use only. It is intended for impurity profiling, analytical method development, and antiviral studies related to hepatitis C virus.
- High purity reference at 98.5% for analytical standards.
- Solid, light yellow to yellow appearance for easy handling.
- Stable under recommended storage conditions as powder and in solvent.
- Soluble in DMSO (100 mg/mL) for stock solution preparation.
- Available in small mg pack sizes suitable for analytical testing.