Drug Standards
Medchemexpress LLC Ganciclovir sodium | 107910-75-8 | 99.92% | 277.21 | 1 G
Ganciclovir (BW 759) sodium is a nucleoside analogue and an orally active antiviral agent effective against CMV. It also exhibits in vitro activity against members of the herpes group and other DNA viruses. It inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
- Orally active antiviral agent
- Effective against CMV
- Inhibits in vitro replication of human herpes viruses (HSV 1 and 2, CMV)
- Inhibits adenovirus serotypes
- IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)
- Can diffuse into the brain
Medchemexpress LLC Mifepristone (Standard) | 84371-65-3 | 99.4% | 429.59 | 50 MG
Mifepristone (Standard) is an analytical standard intended for research and analytical applications. It acts as a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist. This standard is commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist
- Suitable for HPLC, GC, and MS experiments
Medchemexpress LLC Mifepristone | 84371-65-3 | 99.9% | 429.59 | 1 ML
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. It was discovered as the first competitive progesterone antagonist, stimulating a search for more potent and selective antiprogestins.
- Progesterone receptor and glucocorticoid receptor antagonist
- Inhibits cell growth
- Potentiates doxorubicin-induced cytotoxicity in K562/R7 cells
- Reduces severity of EtOH withdrawal in vivo
Medchemexpress LLC (R)-Donepezil ((R)-E2020 free base) | 142698-19-9 | 99.91% ee.: 100.00% | 379.49 | 100 MG
(R)-Donepezil is an R-enantiomer of Donepezil, a specific and potent Acetylcholinesterase (AChE) inhibitor. It is provided as a solid, white to off-white in appearance.
- Specific and potent AChE inhibitor
- R-enantiomer of Donepezil
- Molecular weight: 379.49
- Purity: 99.91%
Medchemexpress LLC (R,1R)-Tenofovir amibufenamide | 1571076-37-3 | 98.9% | 490.49 | 1 MG
(R,1R)-Tenofovir amibufenamide is a drug intermediate that can be used for purifying a tenofovir prodrug. Tenofovir is a nucleoside acid reverse transcriptase inhibitor. It appears as a white to off-white solid and is for research use only.
- Can be used for purifying a tenofovir prodrug
- Appears as a white to off-white solid
- For research use only
Medchemexpress LLC Mifepristone (standard) | 84371-65-3 | 99.4% | 429.59 | 100 MG
Mifepristone (Standard) is an analytical standard of Mifepristone, also known as RU486. It functions as an antagonist for progesterone receptor (PR) and glucocorticoid receptor (GR), exhibiting IC50s of 0.2 nM and 2.6 nM respectively in in vitro assays. This product is designed for research and analytical applications.
- Intended for research and analytical applications
- Functions as a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
- Serves as a reference standard supplied assay
Medchemexpress LLC Raloxifene (Keoxifene) | 84449-90-1 | MFCD00866415 | 99.6% | 473.58 | 25 MG
Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). It exhibits estrogen-agonistic effects on bone and lipids, and estrogen-antagonistic effects on the breast and uterus. Raloxifene is utilized in research for breast cancer and osteoporosis.
- Benzothiophene-derived selective estrogen receptor modulator
- Exhibits estrogen-agonistic effects on bone and lipids
- Exhibits estrogen-antagonistic effects on breast and uterus
- Utilized in research for breast cancer
- Utilized in research for osteoporosis
Medchemexpress LLC Tenofovir disoproxil | 201341-05-1 | >99.5% | 519.44 | 100 MG
Tenofovir disoproxil (Bis(POC)-PMPA) is a nucleotide reverse transcriptase inhibitor. It is used to treat HIV and chronic Hepatitis B infections. This compound is for research use only.
- Nucleotide reverse transcriptase inhibitor
- Used to treat HIV
- Used to treat chronic Hepatitis B
- For research use only
Medchemexpress LLC Tenofovir amibufenamide | 1571076-26-0 | 99.7% | 490.49 | 1 ML
Tenofovir amibufenamide is a Tenofovir prodrug and an orally active antiviral agent for research use. It inhibits HBV and can be used for the study of chronic hepatitis B (CHB).
- Inhibits HBV DNA replication with an EC50 of 7.3 nM in HepG2.2.15 cells.
- Corrects metabolic disorders in host liver cells caused by HBV infection.
- Regulates hepatocyte metabolism and exhibits antiviral effects in HBV transgenic mouse models.
- Decreases HBV DNA levels in serum.
Medchemexpress LLC Raloxifene hydrochloride | 82640-04-8 | 99.8% | 510.04 | 25 MG
Raloxifene hydrochloride is a second-generation, selective, and orally active estrogen receptor modulator. It exhibits estrogen-agonistic effects on bone and lipid metabolism, while demonstrating estrogen-antagonistic effects on uterine endometrium and breast tissue.
- Activates TGF beta 3 promoter as a full agonist
- Inhibits estrogen response element-containing vitellogenin promoter expression
- Acts as a potent uncompetitive inhibitor of human liver aldehyde oxidase
- Functions as a noncompetitive inhibitor of aldehyde oxidase-catalyzed reduction reactions
- Decreases viability in mouse mammary carcinoma cells
- Demonstrates estrogenic activity on bone resorption and serum cholesterol in ovariectomized rats
- Increases bone mineral density in ovariectomized rats
- Reduces serum cholesterol in ovariectomized rats
- Suppresses tumor volumes and decreases lymph node metastasis in mice
Medchemexpress LLC Curcumin-β-D-glucuronide | 227466-72-0 | 98.0% | 544.50 | 1 MG
Curcumin-β-D-glucuronide is a major metabolite found after oral intake of Curcumin in hepatic tissue and portal blood. It is utilized in research concerning colon cancer.
- Major metabolite found after oral intake of Curcumin
- Exhibits potent anti-tumor effects on KRASm/TP53w HCT116 xenograft model
- Suppresses tumor growth by 38% without negatively impacting body weight
- Attenuates NF-κB activity
- For research use only
Medchemexpress LLC Curcumin-β-d-glucuronide | 227466-72-0 | MFCD28963761 | 98.0% | 544.50 | 1 ML
Curcumin-β-d-glucuronide is a major metabolite after oral intake of Curcumin, found in hepatic tissue and portal blood. It is used for research on colon cancer and has demonstrated anticancer properties in mouse tumor models and human metastatic colorectal cancer cell lines by promoting apoptosis. It also shows potential as a colon cancer prevention agent and possesses anti-inflammatory attributes by inhibiting prostaglandin E2 (PGE2) levels.
- Major metabolite of curcumin
- Exhibits anticancer properties
- Promotes apoptosis in cancer cells
- Potential colon cancer prevention agent
- Possesses anti-inflammatory attributes
- Inhibits prostaglandin E2 (PGE2) levels
Medchemexpress LLC (S)-Donepezil | 142057-80-5 | 99.8% | C24H29NO3 | 25 MG
(S)-Donepezil is the S-enantiomer of Donepezil, a specific and potent Acetylcholinesterase (AChE) inhibitor. It appears as a white to off-white solid and is intended for research use only.
- Specific and potent Acetylcholinesterase (AChE) inhibitor.
- Chemical formula: C24H29NO3.
- Molecular weight: 379.49.
- Soluble in DMSO (100 mg/mL).
- Recommended storage for powder: -20°C for 3 years or 4°C for 2 years.
- Recommended storage in solvent: -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Aminopterin | 54-62-6 | 98.7% | C19H20N8O5 | 50 MG
Aminopterin, also known as 4-Aminofolic acid, is a powerful folic acid antagonist. It operates by catalyzing the reduction of folic acid to tetrahydrofolic acid and competitively inhibits dihydrofolate reductase (DHFR) with a high affinity (Ki of 3.7 pM). This compound is recognized for its significant anticancer and immunosuppressive activities, making it a valuable agent in medical applications, particularly in the treatment of pediatric leukemia.
- Acts as a folic acid antagonist
- Competitively inhibits dihydrofolate reductase (DHFR)
- Exhibits anticancer properties
- Possesses immunosuppressive activities
- Used in the treatment of pediatric leukemia
Medchemexpress LLC Cimetidine (SKF-92334) | 51481-61-9 | 99.7% | C10H16N6S | 1 ML
Cimetidine (SKF-92334) is an orally active, inverse, and BBB-permeable histamine H2 receptor antagonist. It is primarily known as a gastric acid reducer and can be used for duodenal and gastric ulcers research. Additionally, Cimetidine demonstrates anti-cancer and anti-inflammatory activities.
- Orally active histamine H2 receptor antagonist
- Gastric acid reducer
- Anti-cancer and anti-inflammatory activity
- For research use only