Acetylides
Medchemexpress LLC Propargyl-PEG7-Boc | 1818294-29-9 | >95% | 1 G
Propargyl-PEG7-Boc is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of a series of PROTACs.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in the synthesis of PROTACs
- Purity >95%
- Soluble in DCM, DMF, DMSO
- Appearance: Pale yellow or colorless oily liquid
Medchemexpress LLC Propargyl-PEG4-amine 1g | 1013921-36-2 | 1 G
Propargyl-PEG4-amine is an alkyne-functional tetraethylene glycol amine used as a linker for bioconjugation and PROTAC synthesis. It provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition and a terminal primary amine for further coupling reactions.
- Provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Contains a tetraethylene glycol spacer to improve solubility and flexibility.
- Offers a terminal primary amine for amide bond formation and other coupling chemistries.
- High purity suitable for synthesis and conjugation (99.7%).
- Molecular weight 231.29 g/mol; formula C11H21NO4.
Medchemexpress LLC Propargyl-PEG12-OH 500mg | 1036204-61-1 | 584.69 | C27H52O13 | 500 MG
Propargyl-PEG12-OH is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a free hydroxyl terminus. It is designed for click chemistry and linker construction in PROTAC synthesis, bioconjugation, and medicinal chemistry, providing a flexible 12-unit PEG spacer with a reactive handle for conjugation.
Medchemexpress LLC 4,7,10,13,16-pentaoxanonadec-18-ynoic acid | 1245823-51-1 | MFCD22201536 | ≥98.0% | 304.34 g·mol⁻¹ | C14H24O7 | 5 G
Propargyl-PEG5-acid is an alkyne-terminated polyethylene glycol linker with five ethylene glycol units used for assembling antibody-drug conjugates, PROTACs, and click-chemistry conjugations. It provides a hydrophilic spacer and reactive termini for modular bioconjugation.
- Alkyne terminus enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions.
- Carboxylic acid terminus allows amide coupling to amines.
- Five-unit PEG spacer increases hydrophilicity and solubility.
- High purity (≥98.0% by NMR) suitable for synthesis applications.
- Moderate molecular weight (304.34 g·mol⁻¹) for predictable linker length.
- Colorless to light yellow liquid; store protected from light at low temperature.
Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG
This compound is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It acts as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Application: Can be employed in the synthesis of PROTACs.
- Characteristics: It contains an alkyne group and can participate in copper-catalyzed azide-alkyne cycloaddition.
Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 1 G
Propargyl-PEG8-acid is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a carboxylic acid, used for conjugation in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Contains a terminal propargyl alkyne for click chemistry.
- Provides a carboxylic acid handle for amide coupling.
- Approximate molecular weight 436.49 g/mol.
- High purity (98.0%) suitable for research applications.
- Available in multiple pack sizes, including 1 G for lab-scale use.
Apexbio Technology LLC Propargyl-PEG2-acid 1859379-85-3 5g
Propargyl-PEG2-acid (CAS 1859379-85-3) is a polyethylene glycol (PEG)-based small molecule featuring a terminal propargyl (alkyne) group and a carboxylic acid moiety The alkyne functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions commonly referred to as click chemistry This enables site-specific conjugation to azide-containing molecules for the synthesis of bioconjugates such as antibody-drug conjugates (ADCs) labeling probes or other functionalized biomolecules Its PEG2 spacer increases solubility and flexibility supporting its application in biomedical research requiring stable and efficient heterobifunctional linkers
Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 99.6% | 143.18 g/mol | C7H13NO2 | 5 G
Propargyl-PEG2-amine is a short polyethylene glycol (PEG2) linker with a terminal propargyl (alkyne) group and a primary amine, used to introduce alkyne handles for click chemistry and bioconjugation.
- Short PEG2 spacer with terminal alkyne and primary amine.
- Suitable for click chemistry (CuAAC) and other bioconjugation reactions.
- Molecular weight 143.18 g/mol; formula C7H13NO2.
- Offered as a 5 g powder; store at 4°C, protect from light, under nitrogen.
- CAS number 944561-44-8 for unambiguous identification.
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 1 G
Propargyl-PEG8-NH2 is a polyethylene glycol (PEG8) alkyne linker bearing a terminal primary amine. It is used as a non-cleavable linker in conjugation chemistry, including ADC and PROTAC synthesis, and as a click-chemistry building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Alkyne functional group for CuAAC click reactions.
- Terminal primary amine for conjugation and linker formation.
- High purity (≥98.0%).
- Molecular weight 407.50 g/mol.
- Chemical formula C19H37NO8.
- Available in multiple package sizes, including 1 G.
Medchemexpress LLC Bis-propargyl-PEG8 50mg | 1092554-87-4 | 50 MG
Bis-propargyl-PEG8 is a polyethylene glycol-based bifunctional linker bearing terminal propargyl (alkyne) groups. It functions as a flexible PEG8 spacer for click-chemistry conjugations, PROTAC construction, and other bioconjugation applications.
- Contains two terminal propargyl (alkyne) groups for CuAAC click reactions.
- PEG8 spacer provides flexibility and increased hydrophilicity.
- Applicable to PROTAC and ADC linker synthesis and general bioconjugation workflows.
- Supplied as a solid, commonly offered in milligram quantities such as 50 mg.
- Characterized by chemical formula C22H38O9 and molecular weight 446.53 g·mol-1.
Medchemexpress LLC Propargyl-PEG5-acid | 1245823-51-1 | 98.0% | 304.34 g/mol | C14H24O7 | 1 G
Propargyl-PEG5-acid is a polyethylene glycol-based linker with a terminal propargyl (alkyne) group and a terminal carboxylic acid. It is used as a non-cleavable PEG spacer in bioconjugation, including antibody-drug conjugate and PROTAC synthesis, and as a reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition.
- Terminal carboxylic acid allows amide bond formation with primary amines.
- Five-unit PEG spacer improves solubility and reduces steric hindrance.
- High purity (98.0%) suitable for bioconjugation.
- Applicable to ADC, PROTAC, and general linker development workflows.
Medchemexpress LLC 4,7,10,13,16,19-hexaoxadocos-21-ynoic acid | 1951438-84-8 | MFCD28950778 | >=97.0% | 348.39 | C16H28O8 | 25 MG
Propargyl-PEG6-acid is a polyethylene glycol (PEG6) linker bearing a terminal propargyl (alkyne) and a terminal carboxylic acid. It is used as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and as a linker in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs).
- Contains a terminal alkyne for CuAAC click reactions.
- Terminal carboxylic acid enables amide coupling and conjugation.
- Molecular weight 348.39; chemical formula C16H28O8.
- Suitable for use as an ADC and PROTAC linker in bioconjugation workflows.
- Recommended storage: pure material at -20°C for long-term stability.
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | MFCD28950778 | >98.0% | 348.39 | C16H28O8 | 1 G
Propargyl-PEG6-acid is a polyethylene glycol (PEG6) linker bearing a terminal propargyl (alkyne) group and a carboxylic acid functional handle, used for click chemistry conjugation such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) in ADC, PROTAC, and bioconjugation workflows.
- Terminal alkyne functional handle for CuAAC click reactions.
- Carboxylic acid group enables amide coupling and further derivatization.
- PEG6 spacer imparts hydrophilicity and flexible linker properties.
- Molecular weight approximately 348.39, suitable for small-molecule linker applications.
- Available in common laboratory quantities for synthesis and conjugation workflows.
Medchemexpress LLC Propargyl-peg2-beta-d-glucose | 2353409-73-9 | 98.0% | C13H22O8 | 10MG
Propargyl-PEG2-beta-D-glucose is an alkyne-functionalized PEG2 linker designed for PROTAC construction and bioconjugation. It offers a terminal propargyl group for click chemistry and a beta-D-glucose-derived spacer to improve solubility and biological compatibility, enabling efficient conjugation in research-scale synthetic workflows.
- Provides terminal alkyne for copper-catalyzed click reactions.
- Contains a two-unit polyethylene glycol spacer for solubility and flexibility.
- Features a beta-D-glucose-derived moiety for biological compatibility.
- Supplied at high purity suitable for synthetic applications.
- Available in small pack sizes for research-scale synthesis.
Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | 471.38 | C19H35BrO8 | 100 MG
Propargyl-PEG8-bromide is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal bromide. It is used for bioconjugation and linker synthesis, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and functioning as a non-cleavable ADC and PROTAC linker.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition.
- Provides an eight-unit polyethylene glycol spacer for flexibility and solubility.
- Has a terminal bromide for nucleophilic substitution or further functionalization.
- Suitable for ADC and PROTAC linker synthesis and click chemistry applications.
- Available in small-scale laboratory quantities for research use.