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1

Medchemexpress LLC Propargyl-PEG7-Boc | 1818294-29-9 | >95% | 1 G
SDP

Propargyl-PEG7-Boc is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of a series of PROTACs.

  • Polyethylene glycol (PEG)-based PROTAC linker
  • Used in the synthesis of PROTACs
  • Purity >95%
  • Soluble in DCM, DMF, DMSO
  • Appearance: Pale yellow or colorless oily liquid

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Propargyl-PEG4-amine 1g | 1013921-36-2 | 1 G
SDP

Propargyl-PEG4-amine is an alkyne-functional tetraethylene glycol amine used as a linker for bioconjugation and PROTAC synthesis. It provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition and a terminal primary amine for further coupling reactions.

  • Provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
  • Contains a tetraethylene glycol spacer to improve solubility and flexibility.
  • Offers a terminal primary amine for amide bond formation and other coupling chemistries.
  • High purity suitable for synthesis and conjugation (99.7%).
  • Molecular weight 231.29 g/mol; formula C11H21NO4.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Propargyl-PEG12-OH 500mg | 1036204-61-1 | 584.69 | C27H52O13 | 500 MG
SDP

Propargyl-PEG12-OH is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a free hydroxyl terminus. It is designed for click chemistry and linker construction in PROTAC synthesis, bioconjugation, and medicinal chemistry, providing a flexible 12-unit PEG spacer with a reactive handle for conjugation.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC 4,7,10,13,16-pentaoxanonadec-18-ynoic acid | 1245823-51-1 | MFCD22201536 | ≥98.0% | 304.34 g·mol⁻¹ | C14H24O7 | 5 G
SDP

Propargyl-PEG5-acid is an alkyne-terminated polyethylene glycol linker with five ethylene glycol units used for assembling antibody-drug conjugates, PROTACs, and click-chemistry conjugations. It provides a hydrophilic spacer and reactive termini for modular bioconjugation.

  • Alkyne terminus enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions.
  • Carboxylic acid terminus allows amide coupling to amines.
  • Five-unit PEG spacer increases hydrophilicity and solubility.
  • High purity (≥98.0% by NMR) suitable for synthesis applications.
  • Moderate molecular weight (304.34 g·mol⁻¹) for predictable linker length.
  • Colorless to light yellow liquid; store protected from light at low temperature.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG
SDP

This compound is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It acts as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.

  • Application: Can be employed in the synthesis of PROTACs.
  • Characteristics: It contains an alkyne group and can participate in copper-catalyzed azide-alkyne cycloaddition.

ENCOMPASS_PREFERRED
6

Apexbio Technology LLC Propargyl-PEG2-acid 1859379-85-3 5g
SDP

Propargyl-PEG2-acid (CAS 1859379-85-3) is a polyethylene glycol (PEG)-based small molecule featuring a terminal propargyl (alkyne) group and a carboxylic acid moiety The alkyne functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions commonly referred to as click chemistry This enables site-specific conjugation to azide-containing molecules for the synthesis of bioconjugates such as antibody-drug conjugates (ADCs) labeling probes or other functionalized biomolecules Its PEG2 spacer increases solubility and flexibility supporting its application in biomedical research requiring stable and efficient heterobifunctional linkers

ENCOMPASS_PREFERRED
7

Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 1 G
SDP

Propargyl-PEG8-acid is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a carboxylic acid, used for conjugation in PROTAC and antibody-drug conjugate (ADC) synthesis.

  • Contains a terminal propargyl alkyne for click chemistry.
  • Provides a carboxylic acid handle for amide coupling.
  • Approximate molecular weight 436.49 g/mol.
  • High purity (98.0%) suitable for research applications.
  • Available in multiple pack sizes, including 1 G for lab-scale use.

ENCOMPASS_PREFERRED
8

Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 99.6% | 143.18 g/mol | C7H13NO2 | 5 G
SDP

Propargyl-PEG2-amine is a short polyethylene glycol (PEG2) linker with a terminal propargyl (alkyne) group and a primary amine, used to introduce alkyne handles for click chemistry and bioconjugation.

  • Short PEG2 spacer with terminal alkyne and primary amine.
  • Suitable for click chemistry (CuAAC) and other bioconjugation reactions.
  • Molecular weight 143.18 g/mol; formula C7H13NO2.
  • Offered as a 5 g powder; store at 4°C, protect from light, under nitrogen.
  • CAS number 944561-44-8 for unambiguous identification.

ENCOMPASS_PREFERRED
9

Medchemexpress LLC Bis-propargyl-PEG8 50mg | 1092554-87-4 | 50 MG
SDP

Bis-propargyl-PEG8 is a polyethylene glycol-based bifunctional linker bearing terminal propargyl (alkyne) groups. It functions as a flexible PEG8 spacer for click-chemistry conjugations, PROTAC construction, and other bioconjugation applications.

  • Contains two terminal propargyl (alkyne) groups for CuAAC click reactions.
  • PEG8 spacer provides flexibility and increased hydrophilicity.
  • Applicable to PROTAC and ADC linker synthesis and general bioconjugation workflows.
  • Supplied as a solid, commonly offered in milligram quantities such as 50 mg.
  • Characterized by chemical formula C22H38O9 and molecular weight 446.53 g·mol-1.

ENCOMPASS_PREFERRED
10

Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 1 G
SDP

Propargyl-PEG8-NH2 is a polyethylene glycol (PEG8) alkyne linker bearing a terminal primary amine. It is used as a non-cleavable linker in conjugation chemistry, including ADC and PROTAC synthesis, and as a click-chemistry building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC).

  • Alkyne functional group for CuAAC click reactions.
  • Terminal primary amine for conjugation and linker formation.
  • High purity (≥98.0%).
  • Molecular weight 407.50 g/mol.
  • Chemical formula C19H37NO8.
  • Available in multiple package sizes, including 1 G.

ENCOMPASS_PREFERRED
11

Medchemexpress LLC Propargyl-PEG1-NHS ester | 1174157-65-3 | 99.7% | 225.20 g/mol | C10H11NO5 | 250 MG
SDP

A non-cleavable one-unit polyethylene glycol (PEG) linker supplied as an NHS ester with a terminal propargyl (alkyne) group. Designed for click chemistry (CuAAC) and antibody-agent conjugation, it is provided as a colorless to light-yellow solid-liquid mixture with high purity and recommended cold storage.

  • One-unit PEG linker for minimal spacer length.
  • Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • NHS ester allows efficient coupling to primary amines.
  • High purity suitable for conjugation chemistry.
  • Cold storage recommended for long-term stability.

ENCOMPASS_PREFERRED
12

Medchemexpress LLC 3-(2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethoxy)propanoic acid | 1807503-85-0 | MFCD28505557 | >95.0% | 264.36 | C10H16O4S2 | 25 MG
SDP

Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker containing a propargyl (alkyne) reactive handle and a disulfide (SS) cleavable bond. It is designed for click-chemistry conjugation and for constructing cleavable antibody-drug conjugates and other bioconjugates.

  • Cleavable disulfide linker enabling reductive release of payload.
  • Propargyl alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Two-unit PEG spacer to improve solubility and reduce steric hindrance.
  • High purity (>95.0%) as determined by NMR.
  • Suitable for ADC linker synthesis and general bioconjugation applications.

ENCOMPASS_PREFERRED
13

Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG
SDP

Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker containing a propargyl (alkyne) group and a disulfide bond, terminating in a carboxylic acid. It is intended for click-chemistry-enabled bioconjugation and as a reducible linker in antibody-drug conjugate synthesis.

  • Cleavable disulfide linkage for reductive release.
  • Alkyne handle compatible with copper-catalyzed azide-alkyne cycloaddition.
  • Carboxylic acid terminus for amide coupling or further functionalization.
  • Purity typically ≥95%.
  • Available in multiple sizes, including 100 mg.
  • Stable when stored under recommended temperatures.

ENCOMPASS_PREFERRED
14

Medchemexpress LLC 4,7,10,13,16-pentaoxanonadec-18-ynoic acid | 1245823-51-1 | MFCD22201536 | >=98.0% | 304.34 g/mol | C14H24O7 | 100 MG
SDP

Propargyl-PEG5-acid is an alkyne-terminated polyethylene glycol (PEG5) linker supplied as a liquid. It is designed for bioconjugation workflows and enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads to azide-functionalized molecules in applications such as antibody-drug conjugate and PROTAC assembly.

  • Contains a terminal alkyne group for copper-catalyzed azide-alkyne cycloaddition.
  • Provides a non-cleavable five-unit PEG spacer to increase solubility and reduce steric hindrance.
  • Suitable for linker synthesis in ADC and PROTAC workflows and other click chemistry applications.
  • Supplied as a liquid in laboratory-scale pack sizes for direct use in reactions.

ENCOMPASS_PREFERRED
15

Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | MFCD28950778 | >98.0% | 348.39 | C16H28O8 | 1 G
SDP

Propargyl-PEG6-acid is a polyethylene glycol (PEG6) linker bearing a terminal propargyl (alkyne) group and a carboxylic acid functional handle, used for click chemistry conjugation such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) in ADC, PROTAC, and bioconjugation workflows.

  • Terminal alkyne functional handle for CuAAC click reactions.
  • Carboxylic acid group enables amide coupling and further derivatization.
  • PEG6 spacer imparts hydrophilicity and flexible linker properties.
  • Molecular weight approximately 348.39, suitable for small-molecule linker applications.
  • Available in common laboratory quantities for synthesis and conjugation workflows.

ENCOMPASS_PREFERRED