Lignans and related compounds
Alkali Scientific Etoposide, 100 Mg
Etoposide, 100mg, is a chemotherapy drug used in laboratory studies to explore the effects of cancer treatments on tumor cells. By inhibiting topoisomerase II, Etoposide induces DNA damage, which triggers cell death, particularly in rapidly dividing cancer cells. This potent anticancer agent is often used in experiments testing its effects on various cancer cell lines and its potential as part of combination therapies. The 100mg volume is suitable for larger-scale studies, offering an efficient amount for detailed investigation into its mechanism of action, pharmacodynamics, and potential therapeutic applications in oncology.
Alkali Scientific Etoposide, 1 G
Etoposide, 1g, is a chemotherapy drug used in cancer research to evaluate its effects on tumor cells. This compound inhibits the enzyme topoisomerase II, which is crucial for DNA replication. By blocking this enzyme, etoposide induces DNA damage that leads to cell death, especially in rapidly dividing cells like those found in tumors. The 1g dosage is ideal for large-scale experiments or studies that require high concentrations of the drug. Researchers use this formulation in cancer studies to understand the mechanisms of DNA damage and cell death, as well as to test its efficacy in combination with other chemotherapeutic agents.
AdipoGen Podophyllotoxin
Chemical. CAS 518-28-5. Formula C22H22O8. MW 414.4. Isolated from Podophyllum emodi rhizomes. Potent microtubule assembly inhibitor. Anticancer compound. Cell death inducer. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase. Antiviral and antihelminthic.
AdipoGen Podophyllotoxin
Chemical. CAS 518-28-5. Formula C22H22O8. MW 414.4. Isolated from Podophyllum emodi rhizomes. Potent microtubule assembly inhibitor. Anticancer compound. Cell death inducer. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase. Antiviral and antihelminthic.
Alkali Scientific Etoposide, 250 Mg
Etoposide, 250mg, is an important anticancer drug used in laboratory experiments focused on cancer cell biology. This compound targets and inhibits topoisomerase II, an enzyme necessary for the unwinding of DNA during replication, causing DNA strand breaks and leading to cell death. Etoposide is widely studied in various experimental cancer therapies and is used in cell lines to assess its cytotoxicity and apoptotic effects. The 250mg formulation provides a higher dosage for more extensive research or clinical trials, making it useful for testing its effects in combination therapies and other cancer treatment strategies.
Alkali Scientific Etoposide, 25 Mg
Etoposide, 25mg, is an anticancer compound used in laboratory research to study the effects of chemotherapy agents. It is commonly used in vitro to examine its ability to inhibit DNA replication and induce apoptosis in cancer cells. Etoposide works by inhibiting topoisomerase II, an enzyme crucial for DNA unwinding during replication. This action leads to DNA strand breaks and ultimately cell death. The 25mg volume is ideal for small-scale laboratory experiments, allowing researchers to test etoposide’s efficacy in various cancer cell lines. It is a crucial reagent in the study of cancer treatment mechanisms and the development of new cancer therapies.
Medchemexpress LLC Podophyllotoxin glucoside | 16481-54-2 | 576.55 | 1 MG
Podophyllotoxin glucoside is a derivative of podophyllotoxin, exhibiting anti-tumor effects. It is suitable for research use and has been tested for cytotoxicity against human HeLa and KB cells.
- Exhibits anti-tumor effects
- Tested for cytotoxicity against human HeLa cells: ED50 of 21.8 μg/mL (after 4 days by trypan blue assay) and IC50 of 6.65 μM (after 72 hours by MTT assay)
- Tested for cytotoxicity against human KB cells: IC50 of 9.25 μM (after 72 hours by MTT assay)
Apexbio Technology LLC Etoposide 33419-42-0 10mM (in 1mL DMSO)
Etoposide (VP-16) is a topoisomerase II inhibitor widely used in biomedical research to study mechanisms of DNA damage and cancer therapy It forms a stabilized complex with DNA and topoisomerase II preventing the enzyme-mediated religation of cleaved DNA strands Resulting DNA double-strand breaks lead to apoptosis particularly in rapidly dividing cancer cells Reported IC50 values vary across cell lines such as 59 2 M for topoisomerase II inhibition 30 16 M in HepG2 and 0 051 M for MOLT-3 indicating differential cytotoxic responses to etoposide in various cancer cell models
TARGETMOL CHEMICALS INC PICROPODOPHYLLOTOXIN 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum) and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors such as receptors for insulin epidermal growth factor platelet-derived growth factor fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R a receptor tyrosine kinase overexpressed in a variety of human cancers plays a critical role in the growth and survival of many types of cancer cells. purity: 99%
Medchemexpress LLC Etoposide phosphate | 117091-64-2 | 99.4% | 668.54 | 1 ML
Etoposide phosphate is a water-soluble derivative and prodrug of etoposide, functioning as a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor. It prevents re-ligation of DNA strands and induces cell cycle arrest, apoptosis, and autophagy, making it suitable for various research applications.
- Potent anti-cancer chemotherapy agent
- Selective topoisomerase II inhibitor
- Prevents re-ligation of DNA strands
- Induces cell cycle arrest, apoptosis, and autophagy
- Water-soluble derivative and probable prodrug of etoposide
- Inhibits HCT116 cell growth in a dose-dependent manner
Apexbio Technology LLC Podophyllotoxin 518-28-5 10mM (in 1mL DMSO)
Podophyllotoxin (CAS 518-28-5) is a naturally occurring lignan that acts as a microtubule assembly inhibitor by binding to tubulin thereby disrupting mitotic spindle formation and inhibiting cell division This mechanism underlies its antineoplastic activity making it a valuable tool in studies of cell cycle regulation cytoskeletal dynamics and anticancer drug development Podophyllotoxin is widely used in biomedical research to investigate mechanisms of cytotoxicity and to screen for compounds targeting mitotic pathways The compound is supplied as 100 mg in a glass bottle or 50 mg in a poly bottle
Medchemexpress LLC Etoposide (Standard) | 33419-42-0 | 99.6% | 588.56 | 100 MG
Etoposide (Standard) is an analytical standard of Etoposide, intended for research and analytical applications. Etoposide is an anti-cancer chemotherapy agent that inhibits topoisomerase II, thereby stopping DNA replication. It induces cell cycle arrest, apoptosis, and autophagy.
- Serves as a reference standard for assays
- Suitable for qualitative, quantitative, and methodological research experiments (e.g., HPLC, GC, MS)
- Inhibits topoisomerase II
- Induces cell cycle arrest, apoptosis, and autophagy
Apexbio Technology LLC Podophyllotoxin 518-28-5 20mg
Podophyllotoxin (CAS 518-28-5) is a naturally occurring lignan that acts as a microtubule assembly inhibitor by binding to tubulin thereby disrupting mitotic spindle formation and inhibiting cell division This mechanism underlies its antineoplastic activity making it a valuable tool in studies of cell cycle regulation cytoskeletal dynamics and anticancer drug development Podophyllotoxin is widely used in biomedical research to investigate mechanisms of cytotoxicity and to screen for compounds targeting mitotic pathways The compound is supplied as 100 mg in a glass bottle or 50 mg in a poly bottle
Medchemexpress LLC Etoposide | 33419-42-0 | 99.9% | 588.56 | 25 MG
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent that inhibits topoisomerase II, thereby stopping DNA replication. It induces cell cycle arrest, apoptosis, and autophagy, making it a valuable tool in cancer research and related studies.
- Inhibits topoisomerase II
- Stops DNA replication
- Induces cell cycle arrest
- Promotes apoptosis
- Triggers autophagy
- Used as an anti-cancer chemotherapy agent
Medchemexpress LLC Etoposide | 33419-42-0 | 588.56 | 1 ML
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent that inhibits topoisomerase II, thereby stopping DNA replication and inducing cell cycle arrest, apoptosis, and autophagy.
- Acts as an anti-cancer chemotherapy agent
- Inhibits topoisomerase II activity
- Stops DNA replication
- Induces cell cycle arrest, apoptosis, and autophagy
- Soluble in DMSO for in vitro studies
- Applicable for cancer and infection research
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