Hydrobromides
eMolecules 2-BROMOPROPYLAMINE HBR | 2403-33-0 | MFCD22055759 | 1g
AstaTech | 2-BROMOPROPYLAMINE HBR | 1g | 410713599 | F11189 | 95.000 | 2403-33-0 | MFCD22055759 | 218.920 | C3H9Br2N
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Apexbio Technology LLC TC-E 5003 17328-16-4 50mg
TC-E 5003 (CAS 17328-16-4) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) exhibiting an IC50 of 1 5 M1 PRMT1 a member of the PRMT family mediates post-translational arginine methylation and is implicated in regulating diverse cellular processes Aberrant PRMT1 activity has been associated with a range of malignancies making it of interest for oncology research In cellular studies TC-E 5003 has been shown to inhibit proliferation and induce apoptosis in MCF7a breast cancer and LNCaP prostate cancer cell lines as well as attenuate androgen-induced gene expression in LNCaP cells This compound serves as a useful tool for investigating PRMT1 function and its role in cancer biology
Selleck Chemical LLC Fenoterol hydrobromide
Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol a 2 adrenoreceptor agonist with bronchodilator activity
Apexbio Technology LLC Homatropine Methylbromide 80-49-9 10mM (in 1mL DMSO)
Homatropine Methylbromide (CAS 80-49-9) is a small molecule antagonist of muscarinic acetylcholine receptors (AChRs) It inhibits muscarinic signaling by blocking receptor activity on endothelial and smooth muscle cells as demonstrated in WKY-E and SHR-E models with IC50 values of 162 5 nM and 170 3 nM respectively This compound is utilized in studies investigating cholinergic modulation of vascular tone and smooth muscle function offering a tool for dissecting the roles of muscarinic receptors in cardiovascular and autonomic research contexts
Medchemexpress LLC Darifenacin hydrobromide | 133099-07-7 | MFCD08141803 | 99.8% | C28H31BrN2O2 | 50 MG
Darifenacin hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist. It exhibits high specificity for M3R, binding >20-fold more specifically than to other muscarinic receptors. This compound is valuable for studying urinary incontinence and other symptoms associated with an overactive bladder. Additionally, it has demonstrated potential in inhibiting tumor growth in colorectal cancer cells, suggesting anti-tumor effects.
- Selective and orally active M3 muscarinic receptor antagonist
- High specificity for M3R
- Useful in studying urinary incontinence and overactive bladder
- Inhibits tumor growth in colorectal cancer cells
- Exhibits anti-tumor effects
Apexbio Technology LLC BD 1047 dihydrobromide 138356-21-5 50mg
BD 1047 dihydrobromide (CAS 138356-21-5) is a selective antagonist of the sigma-1 ( 1) receptor exhibiting Ki values of 0 93 nM for 1 and 47 nM for sigma-2 ( 2) receptors Sigma receptors distinct from opioid receptors include 1 and 2 subtypes and are implicated in modulating dopaminergic neurotransmission and drug-related behaviors In preclinical models BD 1047 dihydrobromide attenuates haloperidol- and DTG-induced dystonia and reverses cocaine-induced behavioral responses without affecting responses to natural rewards Additionally it alleviates mechanical allodynia in neuropathic pain models and modulates spinal 1 receptor and NR1 subunit expression This compound is utilized to investigate 1 receptor function in neuropharmacology and pain research
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 50 MG
Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, with Ki values of 0.92 nM and 3.14 nM, respectively. It is for research use only and not sold to patients.
- 5-HT1B and 5-HT1D receptor agonist
- Antimigraine activity
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 1 ML
Eletriptan hydrobromide is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, primarily used as a laboratory chemical for research purposes. It appears as an off-white to light brown solid with a molecular weight of 463.43.
- 5-HT1B and 5-HT1D receptor agonist
- Demonstrates antimigraine activity
- Ki values of 0.92 nM for 5-HT1B receptor
- Ki values of 3.14 nM for 5-HT1D receptor
- Off-white to light brown solid appearance
- Reduces carotid blood flow in anesthetized dogs (in vivo)
- Inhibits dural plasma protein extravasation in anesthetized rats (in vivo)
Medchemexpress LLC Vortioxetine hydrobromide | 960203-27-4 | MFCD22383961 | C18H23BrN2S | 50 MG
Vortioxetine hydrobromide is a multimodal serotonergic agent exhibiting antidepressant and anxiolytic potential. It functions as an antagonist of 5-HT3A and 5-HT7 receptors, an inhibitor of the 5-hydroxytryptamine transporter (SERT), a 5-HT1A agonist, and a partial 5-HT1B agonist. Research indicates its ability to increase cell proliferation and survival in the dentate gyrus of the hippocampus.
- Antagonizes 5-HT3A and 5-HT7 receptors
- Inhibits 5-hydroxytryptamine transporter (SERT)
- Acts as a 5-HT1A receptor agonist
- Functions as a partial 5-HT1B receptor agonist
- Demonstrates antidepressant and anxiolytic properties
- Increases cell proliferation and survival in the hippocampus
- Does not cause cognitive or psychomotor impairment
Cayman Chemical Clobenpropit hydrobromide
A selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes); reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by (R)-α-methylhistamine at 0.3, 0.1, and 3 nM; decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice at 1 and 3 mg/kg, an effect that can be blocked by (R)-α-methylhistamine or imetit; increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons at 0.1 μM
Medchemexpress LLC Vortioxetine (hydrobromide) | 960203-27-4 | C18H23BrN2S | 1 G
Vortioxetine hydrobromide (Lu AA 21004) is a multimodal serotonergic agent that acts as an antagonist of 5-HT3A (Ki: 3.7 nM) and 5-HT7 (Ki: 19 nM) receptors. It also inhibits the 5-hydroxytryptamine transporter (SERT) with a Ki of 1.6 nM. Furthermore, it functions as a 5-HT1A agonist (Ki: 15 nM) and a partial 5-HT1B agonist (Ki: 33 nM), exhibiting potent inhibition of SERT.
- Antagonist of 5-HT3A and 5-HT7 receptors
- Inhibitor of 5-hydroxytryptamine transporter (SERT)
- Acts as a 5-HT1A agonist
- Functions as a partial 5-HT1B agonist
- High purity of 99.87%
- Light yellow to yellow solid appearance