Hydrochlorides
Medchemexpress LLC Iso-H7 dihydrochloride | 140663-38-3 | 99.1% | 364.29 | 1 MG
Iso-H7 dihydrochloride is a protein kinase inhibitor. It exhibits IC50 values of 22 μM for Protein Kinase C (PKC) and 34 μM for Protein Kinase A (PKA). This compound has been observed to have a negative control effect on PKA in the context of satellite cell myogenesis.
- Potent inhibitor of protein kinases, specifically PKC and PKA.
- Demonstrates inhibitory activity against PKC with an IC50 of 22 μM.
- Inhibits PKA with an IC50 of 34 μM.
- Exerts negative control over PKA's role in satellite cell myogenesis.
- Suitable for research applications.
Medchemexpress LLC Ly-272015 hydrochloride | 172895-15-7 | MFCD00933882 | 99.5% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
LY-272015 hydrochloride is the hydrochloride salt of LY-272015, a selective, orally active 5-HT2B receptor antagonist. It blocks 5-HT or BW723C86-induced ERK2 phosphorylation and has demonstrated antihypertensive activity in DOCA-salt hypertensive rat models. Supplied as a high-purity off-white to light-yellow solid for research use.
- Selective 5-HT2B receptor antagonist.
- Orally active compound suitable for in vivo studies.
- Inhibits 5-HT or BW723C86-induced ERK2 phosphorylation.
- Demonstrated antihypertensive effects in DOCA-salt hypertensive rats.
- High reported purity (99.5%).
- Soluble in DMSO at 5 mg/mL with ultrasonic assistance.
Medchemexpress LLC 2-(2-benzofuranyl)-2-imidazoline hydrochloride | 89196-95-2 | MFCD00672666 | >=98.0% | 222.67 g/mol | C11H11ClN2O | 1 ML
RX 801077 hydrochloride (2-(2-benzofuranyl)-2-imidazoline hydrochloride) is a selective imidazoline I2 receptor (I2R) agonist supplied for research use. It is available as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL), and is commonly used in in vitro pharmacology and receptor-binding studies focused on inflammation and neuroprotection. Consult the safety data sheet for handling and storage.
- Selective imidazoline I2 receptor agonist.
- Available as solid powder and as a 10 mM solution in DMSO, 1 mL.
- High purity suitable for analytical and pharmacological studies.
- Molecular weight 222.67 g/mol; formula C11H11ClN2O.
- Intended for in vitro pharmacology, receptor binding, and neuroprotection research.
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | 99.7% | 269.77 | C14H20ClNO2 | 10 MG
Piperoxan hydrochloride is a research chemical described as an α2 adrenoceptor antagonist and an early-generation antihistamine. Supplied as a solid for laboratory use, it is used as a reference compound in receptor pharmacology and biochemical studies.
- α2 adrenoceptor antagonist activity
- First-generation antihistamine properties
- High reported purity (about 99.7%) suitable for research
- Solid form supplied in small laboratory pack sizes
- Molecular formula C14H20ClNO2; molecular weight 269.77
Medchemexpress LLC RX 801077 (hydrochloride) | 89196-95-2 | MFCD00672666 | 99.8% | 222.6708 | C11H11ClN2O | 10 MG
RX 801077 hydrochloride is a selective imidazoline I2 receptor (I2R) agonist provided for research use as a solid or as a 10 mM solution in DMSO. It is produced with high purity for pharmacological studies, including investigations of neuroprotection and anti-inflammatory mechanisms.
- Selective imidazoline I2 receptor agonist with reported Ki ≈ 70 nM.
- High purity, 99.8% as supplied.
- Available as solid and as a 10 mM solution in DMSO.
- Suitable for pharmacology, neuroprotection, and inflammation research.
- Store at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Soluble in DMSO for stock solution preparation.
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 | C11H17ClN2O3 | 25 MG
Nifenalol hydrochloride is a β-adrenergic receptor antagonist supplied as a white to off-white solid for research use. It is used in pharmacology and cardiac electrophysiology studies, including investigation of early afterdepolarization (EAD) effects. The compound is provided in milligram-scale packs and has manufacturer guidance for solid and solution storage.
- β-adrenergic receptor antagonist for pharmacological research.
- Useful for studying cardiac electrophysiology and EAD mechanisms.
- High reported purity suitable for laboratory assays (99.9%).
- White to off-white solid, stable under recommended storage.
- Available in milligram-scale pack sizes for small-scale experiments.
Medchemexpress LLC GR 55562 dihydrochloride | 159533-25-2 | 99.0% | 448.39 | C23H27Cl2N3O2 | 10 MG
GR 55562 dihydrochloride is a research-grade small molecule that acts as a selective 5-HT1B (serotonin) receptor antagonist for preclinical and in vitro studies probing 5-HT1B-mediated signaling and neurological disease mechanisms.
- Selective 5-HT1B receptor antagonist.
- High purity (99.0%).
- Solid form suitable for analytical and biological assays.
- Store under nitrogen, away from moisture; solvent storage -80°C (6 months) or -20°C (1 month).
- Available in 5 mg and 10 mg pack sizes.
Medchemexpress LLC 5-Hydroxytryptamine creatinine sulfate monohydrate | 61-47-2 | 99.9% | 405.43 | 1 ML
5-Hydroxytryptamine creatinine sulfate monohydrate is an endogenous metabolite. This product is a 10 mM solution in 1 mL of DMSO, suitable for various research applications.
- Purity of 99.87%
- Endogenous metabolite
- Solution in DMSO
- For research use only
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 10 MM * 1 ML
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). This compound also reduces the deposition and crosslinking of collagen I secreted by human fibroblasts. It is for research use only and not sold to patients.
- Specific and effective pan-LOX inhibitor
- Abolishes lysyl oxidase activity
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4)
- Reduces deposition and crosslinking of collagen I secreted by human fibroblasts
- For research use only
eMolecules 2-Pyridylacetic acid, HCl | 16179-97-8 | 5G | Purity: 95%
Combi-Blocks | 2-Pyridylacetic acid, HCl | 5G | 16179-97-8 | MFCD00012812
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Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.
- Acts as a mGlu4 positive allosteric modulator
- Has an EC50 of 19.8 nM
- Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
- Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 1 ML
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.