Hydrochlorides
Medchemexpress LLC TAS-103 dihydrochloride | 174634-09-4 | 98.5% | 406.31 | 50 MG
TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
- Dual inhibitor of DNA topoisomerase I/II.
- Active on CCRF-CEM cells with an IC50 value of 5 nM.
- Significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells.
- Highly cytotoxic to Lewis lung carcinoma (LLC) cells.
- Inhibits the viability of HeLa cells with an IC50 of 40 nM.
- Disrupts signal recognition particle (SRP) complex formation and induces destabilization of SRP14 and SRP19.
- Causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells without obvious body weight loss.
- Liposomal TAS-103 is more active than free TAS-103 in vivo.
Medchemexpress LLC Azepexole (hydrochloride) | 147663-20-5 | MFCD35200177 | >98.0% | 217.7 g/mol | C9H16ClN3O | 5 MG
Azepexole hydrochloride is the hydrochloride salt of azepexole (B-HT 933), a selective α2-adrenoceptor agonist used as a research reagent to study adrenergic receptor pharmacology and related physiological effects such as analgesia and antitussive responses.
- Selective α2-adrenoceptor agonist used in receptor pharmacology studies.
- Reported purity greater than 98% (HPLC).
- Molecular formula C9H16ClN3O and molecular weight 217.7 g/mol.
- Provided as a small-scale research pack suitable for laboratory experiments.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Bestatin hydrochloride | 65391-42-6 | 99.9% | 1 ML
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, primarily employed in cancer research. It demonstrates significant effects on cell differentiation, proliferation, and enzymatic activities both in vitro and in vivo.
- Inhibits CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase.
- Enhances ATRA-induced differentiation in ATRA-sensitive APL NB4 cells.
- Inhibits ATRA-driven phosphorylation of p38 MAPK.
- Slows cell cycle progression, reduces cell growth, and decreases cell division frequency.
- Significantly reduces CD13 expression in diabetic mice.
- Inhibits expression of VEGF and heparanase in diabetic mice.
- Increases the number of splenocytes producing hemolytic anti-SRBC antibodies in vivo.
Medchemexpress LLC Bay-6672 hydrochloride | 2247520-31-4 | 98.0% | C26H28BrCl2N3O3 | 10MG
BAY-6672 hydrochloride is a potent, selective antagonist of the human Prostaglandin F (FP) receptor (reported IC50 ≈ 11 nM). It is used as a research reagent to probe FP receptor signaling and pharmacology and has demonstrated in vivo efficacy in preclinical lung fibrosis models. The compound is supplied as a solid with high reported purity.
- Potent FP receptor antagonism (IC50 ≈ 11 nM).
- Demonstrated in vivo efficacy in preclinical lung fibrosis models.
- Selective for FP over related prostaglandin receptors in published assays.
- High reported purity (~98.0%), suitable for biochemical studies.
- Provided as a solid research reagent for pharmacology and mechanistic assays.
Medchemexpress LLC DCPT1061 hydrochloride | 2289726-31-2 | 99.9% | 375.72 | 5 MG
DCPT1061 hydrochloride is a compound that exhibits a strong inhibitory effect on PRMT1, PRMT6, and PRMT8 in vitro, with little inhibitory effect on epigenetic enzymes such as PRMT3, PRMT4, and PRMT5. It also demonstrates antitumor effects.
- Selective inhibition: Strongly inhibits PRMT1, PRMT6, and PRMT8.
- Minimal off-target effects: Little inhibitory effect on PRMT3, PRMT4, and PRMT5.
- Antitumor properties: Exhibits antitumor effects.
- Research use: For research use only.
Medchemexpress LLC 1,3-propanediol, 2-amino-2-(1-nonyl-1H-1,2,3-triazol-4-yl) hydrochloride | 2376132-24-8 | 99.9% | 320.86 | C14H29ClN4O2 | 10 MG
KARI 201 hydrochloride is a dual-action small-molecule research compound that functions as a selective, brain-penetrant acid sphingomyelinase (ASM) inhibitor and a ghrelin receptor (GHSR) agonist. It is intended for preclinical in vitro and in vivo studies and is supplied as a solid for laboratory research use only.
- Selective acid sphingomyelinase inhibitor.
- Ghrelin receptor agonist with brain penetration.
- High purity, 99.9% (HPLC).
- Molecular weight 320.86 g·mol-1.
- Supplied as a 10 mg solid; store sealed at -20°C.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC PD 128907 hydrochloride | 112960-16-4 | 99.5% | 285.77 g/mol | C14H20ClNO3 | 5 MG
PD 128907 hydrochloride is the hydrochloride salt of a potent, selective dopamine D3 receptor agonist used as a biochemical reagent for pharmacology and dopaminergic signaling research. Supplied as a solid, white to light yellow powder, it has reported purity of 99.51%, molecular formula C14H20ClNO3, and molecular weight 285.77 g/mol.
- Potent D3 receptor agonist with EC50 of 0.64 nM.
- Approximately 53-fold selectivity for D3 over D2 receptors.
- High reported purity suitable for biochemical assays.
- Solid form simplifies storage and handling.
- Stable under recommended sealed storage conditions for short-term and long-term use.
Medchemexpress LLC 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride | 89196-95-2 | MFCD00672666 | >=98.0% | 222.67 g/mol | C11H11ClN2O | 5 MG
RX 801077 hydrochloride (2-BFI) is a research-grade imidazoline I2 receptor (I2R) agonist used in preclinical and in vitro studies to investigate neuroprotective and anti-inflammatory effects. The hydrochloride salt is supplied as a solid and as solution formulations for laboratory use.
- Selective imidazoline I2 receptor agonist with reported Ki ≈ 70.1 nM.
- Demonstrates anti-inflammatory and neuroprotective activity in preclinical studies.
- Available as solid and as 10 mM solution in DMSO.
- Supplied in multiple laboratory pack sizes, including 5 mg.
- Molecular weight 222.67 g/mol.
- CAS number 89196-95-2.
- Purity ≥98% by HPLC.
Medchemexpress LLC Eniporide hydrochlor 25mg | 211813-86-4 | 25MG
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na /H exchange inhibitor
Chem-Impex International, Inc. O-Benzyl-hydroxylamine hydrochloride | 2687-43-6 | MFCD00012952 | 2.5KG
O-Benzyl-hydroxylamine hydrochloride, 2687-43-6, MFCD00012952, 2.5KG