Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Mambalgin 1 TFA | 95.72% | 6554.54 (free acid) | 500 UG
Mambalgin 1 TFA is a potent and selective inhibitor of ASIC1a. It exhibits IC50 values of 192 nM for human ASIC1a and 72 nM for ASIC1a/1b dimer, binding to closed/inactive channels. This compound demonstrates high selectivity for ASIC1a over a range of other channels including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. Research indicates its ability to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.50 | 1 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Peptide inhibitor of Grb7
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM)
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines
Medchemexpress LLC Frakefamide TFA 25mg | 25MG
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC Spantide I (TFA) | 99.32% | 5 MG
Spantide I TFA is a substance P analog and a selective NK1 receptor antagonist. It has Ki values of 230 nM for NK1 and 8150 nM for NK2 receptors. This compound can reduce type 1 cytokines and enhance type 2 cytokine IL-10 in infected corneas, which leads to a significant reduction in corneal perforation. It is for research use only, not for sale to patients.
- Substance P analog
- Selective NK1 receptor antagonist
- Reduces type 1 cytokines
- Enhances type 2 cytokine IL-10
- Reduces corneal perforation
Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects
Medchemexpress LLC 6H05 trifluoroacetate | 2061344-88-3 | 99.0% | 590.14 | C22H31ClF3N3O4S3 | 1MG
6H05 TFA is the trifluoroacetate salt of 6H05, a selective, allosteric inhibitor of the oncogenic mutant K-Ras(G12C) intended for biochemical and cellular research. Supplied as a solid or as a 10 mM DMSO solution, the compound is provided at high purity for assay development and mechanistic studies.
- Selective, allosteric inhibitor of K-Ras(G12C).
- High purity (99.02%).
- Molecular formula C22H31ClF3N3O4S3; molecular weight 590.14.
- Available in small-scale solid quantities and as a 10 mM DMSO solution.
- Suitable for biochemical and cellular assays; for research use only, not for human use.
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 00-00-0 | 99.9% | 1188.38 g/mol | C56H85N17O12·xC2HF3O2 | 100 MG
Lys-Bradykinin TFA is the trifluoroacetate salt of the decapeptide kallidin (Lys-bradykinin), supplied as a purified peptide powder for laboratory research. It acts as a ligand for kallidin and bradykinin receptors and is involved in vascular regulation, inflammation, and pain signaling.
- TFA salt of Lys-bradykinin (kallidin).
- Decapeptide sequence: Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg.
- High purity (99.9%).
- Molecular weight 1188.38 g/mol (free base).
- Storage: powder - sealed, away from moisture and light; powder storage: -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Boc-Met-Leu-Phe (trifluoroacetate) | 00-00-0 | MFCD00037435 | 99.5% | 623.68 g/mol | C27H40F3N3O8S | 1 ML
Boc-MLF TFA is a Boc-protected tripeptide (Boc-Met-Leu-Phe as the trifluoroacetate salt) used as a formyl peptide receptor (FPR) antagonist for receptor pharmacology and cell signaling studies. It is supplied as a 10 mM solution in DMSO (1 mL) or as a dry powder and is offered with high reported purity for research applications.
- Acts as a formyl peptide receptor (FPR) antagonist.
- Inhibits formyl peptide receptor like 1 (FPRL1) at higher concentrations.
- Available as a 10 mM solution in DMSO (1 mL) or as dry powder formats.
- High reported purity suitable for biochemical assays (~99.5%).
- Contains Boc-protected Met-Leu-Phe sequence as the trifluoroacetate salt.
Medchemexpress LLC Ss47 Tfa | 2636072-62-1 | 99.88% | 1067.09 | 1 MG
SS47 TFA is a PROTAC-based HPK1 degrader that facilitates proteasome-mediated HPK1 degradation. This significantly improves in vivo antitumor efficacy in BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies. SS47 (TFA) is also a click chemistry reagent with an Alkyne group, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- PROTAC-based HPK1 degrader
- Facilitates proteasome-mediated HPK1 degradation
- Enhances in vivo antitumor efficacy in BCMA CAR-T cell research
- Targets HPK1, an immunosuppressive regulatory kinase
- Click chemistry reagent with alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 1 MG
DV1 TFA is a selective antagonist of CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry through the CXCR4 co-receptor
Medchemexpress LLC IA9 TFA (human TREM-2 182-190 TFA) | 98.9% | 1001.31 (free acid) | 5 MG
IA9 TFA is a potent, CNS-penetrant inhibitor of Triggering Receptor Expressed on Myeloid cells 2 (TREM-2). It is capable of reducing proinflammatory cytokines and mitigating joint inflammation and damage in a Collagen-induced arthritis mouse model. This compound is suitable for neuroinflammation PET imaging and research related to rheumatoid arthritis and neuroinflammation.
Features and Benefits
- Potent CNS-penetrant TREM-2 inhibitor.
- Diminishes the release of proinflammatory cytokines.
- Suppresses joint inflammation and damage in experimental arthritis.
- Can be used for neuroinflammation PET imaging.
- Applicable for rheumatoid arthritis and neuroinflammation research.
Medchemexpress LLC Tfllr-nh2(tfa) | 1313730-19-6 | 99.6% | 761.83 | 5 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM, intended for research use only. It appears as a white to off-white solid.
- Acts as a selective PAR1 agonist
- Stimulates concentration-dependent increases in [Ca2+]i in neurons
- Activated platelets upregulate E-cadherin and downregulate vimentin expression in SW620 cells
- Increases secreted TGF-β1 in platelet cultures
- Injection into rat paws stimulates marked and sustained oedema
- Stimulates Evans blue extravasation in various organs in wild-type mice
- Can induce both contraction and relaxation in rat duodenal smooth muscle
- Recommended storage for powder is -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent is -80°C for 6 months or -20°C for 1 month
- High solubility in DMSO and H2O (100 mg/mL)
Medchemexpress LLC FTI-2153 (TFA) | 2820151-01-5 | 99.1% | 580.62 g/mol | C27H31F3N4O5S | 10MM 1ML
FTI-2153 TFA is the trifluoroacetic acid salt of a potent farnesyltransferase inhibitor supplied for research use. It is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid amounts, with supporting datasheet, SDS, and COA for characterization and safe handling.
Medchemexpress LLC Parasin I TFA | 219552-69-9 | 99.8% | 2114.33 | 5 MG
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, exhibiting antimicrobial activity. It is intended for research use only and not for patient administration.
- 19-amino acid histone H2A-derived peptide
- Isolated from the skin of catfish
- Shows antimicrobial activity
- White to off-white solid appearance
- Sequence: Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser
- Initial source: Animals, the skin mucus of wounded catfish
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 25KG
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 25KG
