Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cys-PKHB1 TFA | 65.8% | 1487.88 | 1 MG
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, which is a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. This peptide induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. It also induces immune system activation in breast cancer cells through immunogenic cell death.
- Peptide conjugated to PKHB1
- Acts as a CD47 agonist
- Functions as a thrombospondin-1 peptide mimic
- Induces mitochondrial alterations
- Promotes ROS generation
- Leads to intracellular Ca+ accumulation
- Causes calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells
Medchemexpress LLC BIM 23042 trifluoroacetate | 00-00-0 | 96.2% | 1192.45 g/mol (free base) | C63H73N11O9S2.xC2HF3O2 | 5 MG
BIM 23042 TFA is a somatostatin-like octapeptide analogue that functions as a selective antagonist of the neuromedin B receptor (NMB-R/BB1). Supplied as the trifluoroacetate (TFA) salt at high purity, it is intended for research use in receptor pharmacology and related biochemical assays.
- Selective antagonist of neuromedin B receptor (BB1).
- TFA salt form for improved handling and stability.
- High purity suitable for receptor pharmacology and calcium mobilization assays.
- Supplied as a small, lyophilized quantity for laboratory research use.
- Molecular weight and elemental composition available in the product documentation.
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 5 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4) and exhibits antiviral activity. This product is for research use only and has not been fully validated for medical applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- For research use only
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC WP9QY (TFA) | 98.7% | 1340.40 | 500 UG
WP9QY TFA is a biologically active cyclic peptide that acts as a TNF-α antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, thereby preventing interactions between TNF and its receptor. This TNF antagonist serves as a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. This product is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics TNF recognition loop on TNF receptor I
- Prevents interactions of TNF with its receptor
- Useful for developing small molecular inhibitors
- Prevents inflammatory bone destruction in rheumatoid arthritis
- Prevents systemic bone loss in rheumatoid arthritis
Medchemexpress LLC Balixafortide TFA | 99.89% | 1978.16 | 50 MG
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. It shows 1000-fold selectivity for CXCR4 compared to a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. It is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent and exhibits anti-cancer effects.
- Potent, selective, well-tolerated peptidic CXCR4 antagonist
- High selectivity for CXCR4 (1000-fold over CXCR7)
- Blocks β-arrestin recruitment and calcium flux
- Potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent
- Anti-cancer effects
- Optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 1 MG
DV1 TFA is a selective antagonist of CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry through the CXCR4 co-receptor
Medchemexpress LLC Ala-MPSD TFA | 136561-67-6 | 98.02% | 3016.76 (free base) | 1 MG
Ala-MPSD TFA is a control peptide for MPSD. In this peptide, the four serine residues of MPSD are substituted by alanines. This product is intended for research use only.
- Control peptide for MPSD
- Four serine residues substituted by alanines
- For research use only
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 1 MG
Glycyl-Exatecan TFA is an anticancer agent derived from Exatecan. It exhibits significant antitumor activity and is suitable for research on cancers such as solid tumors.
- Anticancer agent
- Derivative of Exatecan
- Exhibits significant antitumor activity
- Utilized in research for various cancers, including solid tumors
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC Psalmotoxin 1 TFA | 880107-52-8 | 99.37% | 4689.39 | 500 UG
Psalmotoxin 1 is a protein toxin that binds at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). It acts as a potent and selective ASIC1a inhibitor by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis and inhibit cell migration, proliferation, and invasion of cancer cells. It is utilized in research concerning cancers and neurological diseases.
- Potent and selective ASIC1a inhibitor with an IC50 of 0.9 nM
- Induces cell apoptosis
- Inhibits cell migration, proliferation, and invasion of cancer cells
- Used in research concerning cancers and neurological diseases
- Neuroprotective in a conscious model of stroke
- Inhibits tumor growth in breast cancer models
Medchemexpress LLC PBP10 TFA | 98.2% | 1826.07 | 1 MG
PBP10 is a cell-permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. This 10-AA peptide, with rhodamine conjugated at its N-terminus, exhibits bactericidal activity against gram-positive and gram-negative bacteria and mitigates microbial-induced inflammatory effects.
- Cell-permeable
- Selective gelsolin-derived peptide inhibitor of FPR2 over FPR1
- 10-AA peptide with rhodamine conjugated at its N-terminus
- Exerts bactericidal activity against gram-positive and gram-negative bacteria
- Limits microbial-induced inflammatory effects
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1 MG
Cyclorasin 9A5 (TFA) from MedChemExpress is a laboratory chemical intended for research use only. It is presented as a solid and is stable under recommended storage conditions, emphasizing careful handling and storage to maintain its integrity.
- Stable under recommended storage
- Keep sealed in cool, well-ventilated area, away from direct sunlight and ignition
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Solution storage: -80°C for 6 months, -20°C for 1 month
- Ships at room temperature (less than 2 weeks)
- Not classified as hazardous
- Requires personal protective equipment (safety goggles, gloves, impervious clothing, respirator)
- Ensure adequate ventilation, safety shower, and eye wash station
Medchemexpress LLC Cef20 TFA | 99.3% | 1057.19 | 5 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). It is for research use only.
- An HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503)
- For research use only
Medchemexpress LLC WP9QY TFA | 99.4% | 1340.40 | 1 MG
WP9QY, a TNF-a Antagonist, is a biologically active peptide.
- This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I.
- It prevents interactions of TNF with its receptor.
- This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.