Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Nampt-IN-10 (TFA) | 2567724-20-1 | >98.6% | 701.59 | 25 MG
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. It shows cellular potency to A2780 and CORL23 cell lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs.
- Shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines.
- IC50 values are 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), and 1 nM (NCI-N87 with HER2 expressing).
- Can be used as a novel non-antimitotic payload for ADCs.
![Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000201969.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML
SN-38-CO-DMEDA TFA is a research-grade carbamate intermediate (trifluoroacetate salt) used in the synthesis of antibody-drug conjugates such as LND1035. Supplied as a 10 mM solution in DMSO (1 mL), it has CAS number 1224601-17-5, chemical formula C29H31F3N4O8, molecular weight 620.57 g/mol, and reported purity 98.07%.
- 10 mM solution in DMSO, 1 mL
- Intended for use as a chemical synthesis intermediate
- Reported purity 98.07%
- CAS number 1224601-17-5
- Available as solid quantities in multiple sizes
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 | C25H31F3N12O10S2 | 5 MG
Ceftolozane TFA is the trifluoroacetic acid (TFA) salt of a cephalosporin antibiotic supplied as a solid for research use. It is used to study and inhibit Gram-negative bacterial infections and as a synthetic building block for development of new antibiotic derivatives.
- Cephalosporin-class antibiotic active against Gram-negative bacteria.
- Useful as a synthetic intermediate for antibiotic development.
- High purity (98.2%) suitable for analytical and synthetic work.
- White to off-white solid form for easy handling and storage.
- Available in milligram-scale quantities for research applications.
- Store at -20°C sealed; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
- For research use only; not for human or veterinary use.
Medchemexpress LLC LY117018 TFA 5mg | 2390041-98-0 | 573.58 | C29H26F3NO6S | 5 MG
LY117018 TFA is the trifluoroacetic acid salt of LY117018, a raloxifene analog and selective estrogen receptor modulator reported to exert antiproliferative effects on breast cancer cell lines. It is provided as a research reagent for in vitro and in vivo studies of estrogen receptor signaling and related pathways.
- Selective estrogen receptor modulator with reported antiproliferative activity.
- Soluble in DMSO up to 100 mg/mL; sonication may be required.
- In vivo formulations reported with solubility ≈5 mg/mL using common co-solvent systems.
- Recommended storage: solid sealed and kept away from moisture; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular formula C29H26F3NO6S; molecular weight 573.58.
Medchemexpress LLC GRGDSPC TFA | 99.2% | 804.75 | 5 MG
GRGDSPC TFA is a 7-amino acid thiolated cell adhesion peptide. It is utilized in conjugation reactions with acrylated dextran to regulate the interactions of human mesenchymal stem cells (hMSCs) with photocrosslinkable hydrogels.
- Thiolated cell adhesion peptide
- Composed of 7 amino acids
- Regulates human mesenchymal stem cell interactions
- Suitable for research applications
Medchemexpress LLC Ceftolozane TFA 1mg | 1628046-32-1 | 1MG
Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer[1
Medchemexpress LLC Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) | 96.6% | 7588.60 (free base) | 1 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide and the main toxin found in scorpion venom. This peptide specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6, making it a valuable tool for research in ion channel modulation and neurological diseases.
- Neurotoxic peptide
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Functions as an ion channel modulator
- Useful in neurological disease research
- Acts as an inhibitor
Medchemexpress LLC BTR2000 TFA | 99.0% | 764.83 | 5 MG
BTR2000 TFA is a specifically KLHL20 ligand that binds to the KLHL20 Kelch domain with high affinity. It can be utilized as a ligand for E3 ligase in the synthesis of BTR2004.
- Specifically targets KLHL20
- Binds to the KLHL20 Kelch domain with high affinity
- Useful as a ligand for E3 ligase
- Used for the synthesis of BTR2004
Medchemexpress LLC Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Apexbio Technology LLC Urotensin-II-114-124-human-TFA
Urotensin II (114-124 human) TFA (CAS No 251293-28-4) is a peptide fragment primarily utilized in cardiovascular and neurological research It originates from human urotensin II a potent vasoactive peptide involved in various physiological processes primarily acting through the G protein-coupled urotensin II receptor (UT) This interaction influences cellular pathways related to vasoconstriction and vascular smooth muscle proliferation In vitro this fragment functions in the nanomolar to low micromolar range demonstrating significant potency in cellular assays Typically employed in cell models and animal studies it aids in exploring cardiovascular dysfunction evaluating potential therapeutic agents and drug screening protocols Experimental concentrations typically depend on the specific research design ensuring flexibility for diverse investigative focuses