Benzoxadiazoles
Medchemexpress LLC Nbd-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 1 ML
NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It demonstrates potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Potent HIV-1 entry inhibitor
- Blocks gp120-CD4 interaction
- Shows potent cell fusion and virus-cell fusion inhibitory activity
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 strains
- Inhibits CD4-dependent virus in a dose-dependent manner
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 25 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor. It functions by blocking the gp120-CD4 interaction. NBD-556 exhibits potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion.
- Inhibits the infection of MT-2 cells by laboratory-adapted HIV-1 strains.
- Inhibits CD4-dependent virus in a dose-dependent manner.
Medchemexpress LLC Nbd-556 | 333353-44-9 | 99.5% | C17H24ClN3O2 | 100 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Inhibits HIV-1 entry by blocking gp120-CD4 interaction.
- Shows potent cell fusion and virus-cell fusion inhibitory activity.
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion.
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains.
- Inhibits CD4-dependent virus in a dose-dependent manner.
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 50 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It demonstrates potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Functions as a CD4 mimetic
- Potent HIV-1 entry inhibitor
- Blocks gp120-CD4 interaction
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 strains
- Inhibits CD4-dependent virus in a dose-dependent manner
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 50 MG
NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. It binds to HIV-1 gp120 and demonstrates potent antiviral activity (EC50 < 200 nM). It is active against HIV-1 in single-cycle (TZM-bl cells) and multi-cycle (MT-2 cells) assays.
- Potent HIV-1 entry antagonist with an IC50 of 89 nM
- Binds to HIV-1 gp120
- Demonstrates potent antiviral activity (EC50 < 200 nM)
- Prevents HIV-1 mediated cell-cell fusion
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 25 MG
NBD-14189 is a potent HIV-1 entry antagonist that binds to HIV-1 gp120, exhibiting potent antiviral activity. It demonstrates anti-HIV-1 activity and cytotoxicity in both single-cycle (TZM-bl cells) and multi-cycle (MT-2 cells) assays, and prevents HIV-1 mediated cell-cell fusion.
- Potent HIV-1 entry antagonist (IC50 of 89 nM against HIV-1HXB2 pseudovirus)
- Binds to HIV-1 gp120
- Potent antiviral activity (EC50<200 nM)
- Anti-HIV-1 activity (IC50=0.089 μM) and cytotoxicity (CC50=21.9 μM) in single-cycle assays
- Anti-HIV-1 activity (IC50=0.18 μM) and cytotoxicity (CC50=22.1 μM) in multi-cycle assays
- Prevents HIV-1 mediated cell-cell fusion (IC50=9.4 μM)
- Weak or no inhibition of hERG current (IC50=3.0 μM)
Medchemexpress LLC 25-NBD Cholesterol | 105539-27-3 | 99.0% | 564.76 | 1 MG
25-NBD Cholesterol is a fluorescently labeled form of cholesterol that facilitates the distinction between exogenous and endogenous cholesterol within bacterial cell membranes, emitting green fluorescence signals.
- Fluorescently labeled form of cholesterol.
- Facilitates distinction between exogenous and endogenous cholesterol within bacterial cell membranes.
- Emits green fluorescence signals.
Medchemexpress LLC Nbd-557 | 333352-59-3 | 99.4% | C17H24BrN3O2 | 100 MG
NBD-557 is a small molecule organic compound identified as a potent HIV-1 inhibitor. It targets viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the cellular receptor CD4, without affecting later stages of the HIV-1 life cycle such as reverse transcriptase, integrase, or protease.
- Potent cell and virus-cell fusion inhibitory activity
- Active against both X4 and R5 viruses in CXCR4 and CCR5 expressing cell lines
- Binds to unliganded HIV-1 gp120
- Active against laboratory-adapted strains and primary isolates of HIV-1
Medchemexpress LLC NBD-PE | 178119-00-1 | 99.9% | 956.24 | 5 MG
NBD-PE is an effective lipid fluorescent probe with Excitation/Emission at 465/535 nm and a green color. It has wide applications in membrane and cell biology.
- Effective lipid fluorescent probe
- Excitation/emission: 465/535 nm
- Color: green
- Wide array of applications in membrane and cell biology
Medchemexpress LLC 1H-Pyrrole-2-carboxamide, N-[(1S)-2-amino-1-[4-(hydroxymethyl)-2-thiazolyl]ethyl]-5-[3-fluoro-4-(trifluoromethyl)phenyl]- | 2234273-72-2 | 99.8% | 428.40 | 1 ML
NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. It binds to HIV-1 gp120 and demonstrates potent antiviral activity (EC50 < 200 nM). It is intended for research use only.
- Potent HIV-1 entry antagonist
- Binds to HIV-1 gp120
- Shows potent antiviral activity (EC50<200 nM)
- Anti-HIV-1 activity (IC50=0.089 μM) in single-cycle (TZM-bl cells) assays
- Prevents HIV-1 mediated cell-cell fusion
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 100 MG
NBD-14189 is a potent HIV-1 entry antagonist, binding to HIV-1 gp120 and demonstrating potent antiviral activity against the HIV-1HXB2 pseudovirus. It shows anti-HIV-1 activity in both single-cycle and multi-cycle assays.
- Potent HIV-1 entry antagonist
- Binds to HIV-1 gp120
- Exhibits potent antiviral activity (EC50 < 200 nM)
- Prevents HIV-1 mediated cell-cell fusion
- Shows weak or no inhibition of the hERG current
Medchemexpress LLC NBD-557 | 333352-59-3 | 99.4% | C17H24BrN3O2 | 25 MG
NBD-557 is a small molecule organic compound identified as a potential HIV-1 inhibitor. It targets viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the CD4 receptor without affecting later stages of the HIV-1 life cycle.
- Exhibits potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Active against X4 and R5 viruses, and laboratory-adapted HIV-1 strains, including an AZT-resistant strain.
- Binds to unliganded HIV-1 gp120, but not to the cellular receptor CD4.
Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | 100 MG
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist. It binds to HIV-1 gp120 and shows potent antiviral activity.
- Potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses.
- Binds to HIV-1 gp120.
- Low cytotoxicity (CC50>100 μM).
- Anti-HIV-1 activity (IC50=0.16 μM) and Cytotoxicity (CC50=109.3 μM) in single-cycle (TZM-bl Cells) assay.
- Does not induce toxicity in the U87-CD4-CXCR4 cell line at doses used for assay.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 390.46 | C19H28N5O4 | 5 MG
NBD-Pen is a turn-on fluorescent probe for selective detection of lipid-derived radicals in biological systems. It enables live-cell imaging and biochemical studies of lipid peroxidation and oxidative stress with sensitive fluorescence readout.
- High selectivity and sensitivity for lipid radicals.
- Turn-on fluorescence enables low-background detection in cells.
- Excitation at 470 nm and emission at 530 nm for standard imaging.
- High purity (99.94%) suitable for research use.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light; follow solvent storage guidelines.
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | 337.84 g·mol-1 | C17H24ClN3O2 | 10 MG
NBD-556 is a small-molecule CD4 mimetic that inhibits HIV-1 entry by blocking the gp120-CD4 interaction. It is supplied as a solid research compound for use in biochemical and cell-based assays investigating viral entry and fusion.
- CD4 mimetic that blocks the gp120-CD4 interaction.
- Inhibits HIV-1 entry and fusion in cell-based assays.
- High purity (99.6%).
- Molecular weight 337.84 g·mol-1.
- CAS number 333353-44-9.
- Soluble in DMSO (≈33.33 mg/mL); ultrasonic treatment may be required.
- Supplied as a 10 mg solid; store powder at -20°C for long-term storage.
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