Benzoxazines

TARGETMOL CHEMICALS INC CORNUSIDE 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-(kappa)B inhibition as well as the negative regulation of ERK1/2 p38 and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity and improvements in mitochondrial energy metabolism and antioxidant properties. purity: 99%

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TARGETMOL CHEMICALS INC AM580 25MG

Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AM580 (CD336) is a retinoic acid receptor agonist that is selective for RAR(alpha)( IC50 8 nM )purity: 99%

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TARGETMOL CHEMICALS INC R 59-022 HYDROCHLORIDE 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC502.8 µM) that inhibits the phosphorylation of OAG to OAPA.R 59-022 enhances thrombin-induced triglyceride production in platelets and inhibits the production of phosphatidic acid in neutrophils. R 59-022 enhances thrombin-induced diglyceride production in platelets and inhibits phosphatidic acid production in neutrophils. purity: 97%

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TARGETMOL CHEMICALS INC SELINEXOR KPT-330 25MG

Also available in 2 mg 5 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Selinexor (KPT-330) is an orally available small molecule inhibitor of CRM1 (chromosome region maintenance 1 protein exportin 1 or XPO1) with potential antineoplastic activity. purity: 99%

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TARGETMOL CHEMICALS INC COMPSTATIN 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Compstatin a cyclic tridecapeptide which was originally discovered from phage-display libraries is a highly potent and selective C3 inhibitor. purity: 100%

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TARGETMOL CHEMICALS INC GDC0084 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations. purity: 99%

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TARGETMOL CHEMICALS INC DECURSIN 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects potentially by inhibiting the TGF-(beta)1 induced NOX activation and Smad signaling. 3. Decursin has anti-cancer activity mediated suppression of the PKC(alpha) MAPK and NF-(kappa)B pathways in MCF-7 cells. 4. Decursin exhibits cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity. purity: 97%

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TARGETMOL CHEMICALS INC MOSLOFLAVONE 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-(alpha) and IL-1(beta) with IC50 values of 0.71 uM and 7.8 uM respectively. purity: 98%

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TARGETMOL CHEMICALS INC BALOXAVIR MARBOXIL 250MG

Also available in 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Baloxavir marboxil (S-033188) is a novel cap-dependent endonuclease inhibitor for the treatment of influenza A and B virus infections. purity: 98%

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TARGETMOL CHEMICALS INC NESBUVIR 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons. purity: 98%

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Amsbio LLC Fibronectin (FN1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1G2]

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Fibronectin (FN1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1G2]

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TARGETMOL CHEMICALS INC ISOORIENTIN 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Isoorientin (Homoorientin) has antioxidant activity. purity: 98%

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TARGETMOL CHEMICALS INC FA16 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. FA16 is a selective metabolically stable ferroptosis inducer with an IC50 value of 1.26 uM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth.

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TARGETMOL CHEMICALS INC SHIELD-1 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Shield-1 is a specific high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP) and reverses the instability by binding to mutated FKBP (mtFKBP) allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein. purity: 99%

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Medchemexpress LLC Zilovertamab vedotin | 98.6% | 1 MG

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Zilovertamab vedotin is an antibody-drug conjugate for preclinical cancer research that combines a humanized anti-ROR1 monoclonal antibody with the cytotoxic payload monomethyl vedotin. It is supplied as a lyophilized powder for experimental use.

• targets receptor tyrosine kinase-like orphan receptor 1 (ROR1)
• contains monomethyl vedotin cytotoxic payload
• suitable for in vitro and in vivo research
• high reported purity (98.61%)
• documentation available: certificate of analysis and safety data sheet

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