Biotin and derivatives
Medchemexpress LLC Bis-SS-C3-NHS ester | 98604-88-7 | 98.0% | 432.47 g/mol | C16H20N2O8S2 | 10 MG
Bis-SS-C3-NHS ester is a cleavable disulfide-containing N-hydroxysuccinimide (NHS) ester linker used for bioconjugation. It reacts with primary amines to form stable amide bonds, and the internal disulfide provides a reducible linkage for intracellular payload release, making it suitable for antibody-drug conjugate synthesis and conjugation method development.
- Cleavable disulfide linker for controlled payload release
- N-hydroxysuccinimide (NHS) ester reactive toward primary amines
- High purity suitable for research-scale conjugation
- Available in multiple small-scale pack sizes for method development
- Stable when stored sealed at -20°C and protected from moisture
Medchemexpress LLC Bis-PEG30-NHS ester | 1633.81 | 5 MG
Bis-PEG30-NHS ester is a non-cleavable 30-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is designed for various laboratory applications.
- Non-cleavable 30-unit PEG ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
Medchemexpress LLC DSPE-Biotin | 133695-76-8 | 97.5% | 974.36 g·mol⁻¹ | C51H96N3O10PS | 100 MG
DSPE-Biotin is a biotin-functionalized phospholipid used to introduce biotin groups into lipid membranes and liposome surfaces for biochemical and bioconjugation applications. It enables high-affinity capture and labeling of lipid particles via streptavidin/avidin interactions and is supplied for research use with recommended storage protected from light at low temperature.
- Biotin-functionalized phospholipid for membrane and liposome functionalization.
- Enables high-affinity binding to streptavidin/avidin systems for capture and targeting.
- Suitable for bioconjugation, labeling, and assay development with lipid particles.
- High reported purity (97.5%).
- Supplied as 100 MG and intended for research use only.
- Store protected from light at -20 °C for long-term stability.
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 100 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. PROTACs typically consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Serves as a linker in the construction of PROTACs
- Linker is based on Polyethylene Glycol (PEG)
- Intended for research purposes only
- Primary application is in the synthesis of PROTACs
Apexbio Technology LLC Concanavalin A (Con A)-Biotin 5x5mg(5 mg/mL)
Concanavalin A (Con A) is a lectin protein derived from Canavalia ensiformis (jack bean) with a molecular weight of approximately 104 kDa Each subunit can bind one Ca2 and one Mn2 ion and contains a carbohydrate-binding site Upon binding these metal ions Con A specifically binds to glycoproteins glycolipids and carbohydrates containing -D-glucose and -D-mannose residues Biotin is a small-molecule water-soluble vitamin that exhibits very strong affinity to avidin Concanavalin A-Biotin is a labeled protein conjugate composed of Concanavalin A linked to biotin widely used in biological research especially for detecting and quantifying biomolecules containing specific carbohydrate structures through immunohistochemistry (IHC) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 99.0% | 250 MG
Mal-PEG8-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are molecules that harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
Medchemexpress LLC Biotin-azide (N-(3-Azidopropyl)biotinamide) | 908007-17-0 | 99.8% | 25 MG
Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. It can be used to prepare various biotinylated conjugates via Click Chemistry. It is a click chemistry reagent, containing an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- A form of biotin with a terminal azide group.
- Can be used to prepare various biotinylated conjugates via click chemistry.
- Contains an azide group for copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups.
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Medchemexpress LLC DBCO-PEG12-NHS ester | 2093934-94-0 | 96.1% | C50H71N3O18 | 25 MG
DBCO-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Features a DBCO group for SPAAC
- Facilitates strain-promoted alkyne-azide cycloaddition with azide groups
- PROTACs utilize the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG2-NHS ester | 596820-83-6 | 96.7% | C21H32N4O8S | 50 MG
Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- For research use only
- White to off-white solid appearance
- Molecular weight of 500.57
- Powder can be stored at -20°C for 3 years
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 125 mg/mL
Medchemexpress LLC B7-H6 Human Biotin 50ug | 50ug
B7-H6 a distinctive monomeric protein uniquely triggers NCR3-dependent natural killer (NK) cell activation specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1 NCR2 and KLRK1) This specificity underscores B7-H6 s unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms B7-H6 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H6 protein expressed by HEK293 with C-His C-Avi labeled tag
eMolecules 756525-90-3 | M-PEG8-NHS ESTER | AstaTech | MFCD13184969 | 509.549 | C22H39NO12 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 624137097
M-PEG8-NHS ESTER | AstaTech | 756525-90-3 | MFCD13184969 | 509.549 | C22H39NO12 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 624137097
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 50 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC Ccnd3 protein, human (biotinylated, MBP, His, Flag) | >85.0% | 50UG
Recombinant human cyclin D3 (CCND3) is supplied as a biotinylated, affinity-tagged protein spanning amino acids M1-L292. The product is expressed in E. coli and formulated for research applications including binding assays, pull-downs, and antibody validation; consult the SDS/COA for storage and handling information.
- Biotinylated for streptavidin capture and sensitive detection.
- N-terminal MBP tag to enhance solubility and facilitate purification.
- C-terminal 6xHis and Flag tags for affinity purification and versatile detection.
- Full-length human sequence (M1-L292) preserves native epitopes.
- Expressed in E. coli for reproducible recombinant production.
- Purity greater than 85% as determined by reducing SDS-PAGE.
- Available in small research sizes suitable for assay development.
Medchemexpress LLC Bis-PEG25-NHS ester | 2221948-96-3 | MFCD21363290 | 99.8% | 1413.55 | C62H112N2O33 | 25 MG
Bis-PEG25-NHS ester is a PEG/alkyl/ether-based homobifunctional linker containing two N-hydroxysuccinimide (NHS) ester groups, used for conjugation in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is provided as a hydrophilic solid for use in organic solvents and should be stored sealed at -20°C.
- Contains two amine-reactive NHS ester groups for conjugation.
- PEG spacer increases hydrophilicity and solubility in aqueous media.
- Suitable as a cleavable linker for ADC and PROTAC synthesis.
- Provided as a solid with recommended cold, sealed storage to preserve stability.
Medchemexpress LLC Amine-PEG3-Biotin | 359860-27-8 | 99.8% | 418.55 | 10 MG
Amine-PEG3-Biotin is a signal amplification label that contains a biotin group and a terminal primary amine group. It is for research use only.
- Signal amplification label
- Contains a biotin group
- Contains a terminal primary amine group
- For research use only