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Biotin and derivatives

Organic heterocyclic compounds and derivatives that consist of a ureido ring and a tetrahydrothiophene ring; ureido contains the radical: NH2CONH−, and tetrahydrothiophene is a five-membered ring consisting of four carbon atoms and a sulfur atom.

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1

Medchemexpress LLC Sulfo-NHS-biotin (sodium) | 194041-65-1 | 95.0% | 443.43 | 50 MG
SDP

Sulfo-NHS-Biotin sodium is a low-molecular-weight tracer used to assess blood-brain barrier permeability. It functions as a passive tracer for detecting blood-brain barrier permeability in mouse models of traumatic brain injury. No inherent pharmacodynamic effects have been observed for this product.

  • Low-molecular-weight tracer
  • Used to assess blood-brain barrier permeability
  • Detects blood-brain barrier permeability in mouse models of traumatic brain injury
  • Serves as a passive tracer
  • No inherent pharmacodynamic effects observed

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Azido-PEG5-NHS ester | 1433996-86-1 | ≥98.0% | C17H28N4O9 | 50 MG
SDP

Azido-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups, leveraging the ubiquitin-proteasome system for selective protein degradation.

  • Used in the synthesis of PROTACs
  • Functions as a click chemistry reagent
  • Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
  • Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
  • Enables targeted protein degradation

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.7 g/mol | C26H41N5O7S | 50 MG
SDP

Biotin-LC-LC-NHS is a long-chain N-hydroxysuccinimide (NHS) activated biotinylation reagent used to label proteins, antibodies, and small molecules. The LC-LC spacer reduces steric hindrance during conjugation, and the NHS ester reacts with primary amines to form stable amide bonds.

  • Provides long-chain spacer (LC-LC) to reduce steric hindrance.
  • Reactive NHS ester for amine-selective conjugation.
  • Suitable for labeling antibodies and small molecules.
  • Solid, white to light yellow appearance; store under inert gas and protect from light.
  • Soluble in DMSO; follow recommended solvent and storage guidance.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC Biotin-Val-Ala-Asp(OMe)-FMK | 1135688-15-1 | ≥95.0% | 672.81 g/mol | C30H49FN6O8S | 50 MG
SDP

Biotin-VAD-FMK is a biotin-labeled, cell-permeable, irreversible pan-caspase inhibitor used to identify and label active caspases in cell lysates. It serves as an affinity probe for detection or capture of active caspases in apoptosis research and protease-profiling workflows, and is compatible with biochemical assays and pull-down experiments.

  • Biotin-labeled for affinity capture and detection.
  • Cell-permeable, irreversible caspase inhibitor.
  • Enables identification and labeling of active caspases in cell lysates.
  • Compatible with biochemical assays, protease profiling, and pull-down workflows.
  • Supplied as a solid with defined molecular weight and formula for experimental planning.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Propanoic acid, 3-(2-azidoethoxy)-, 2,5-dioxo-1-pyrrolidinyl ester | 1807530-06-8 | 99.8% | C9H12N4O5 | 50 MG
SDP

Azido-PEG1-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.

  • PEG-based PROTAC linker
  • Utilized in the synthesis of PROTACs
  • Functions as a click chemistry reagent
  • Contains an azide group
  • Facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
  • Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
  • Suitable for use with molecules containing alkyne, DBCO, or BCN groups
  • Enables selective degradation of target proteins

ENCOMPASS_PREFERRED
6

Medchemexpress LLC Acetic acid, 2-(2-cyclooctyn-1-yloxy)-, 2,5-dioxo-1-pyrrolidinyl ester | 1425803-45-7 | MFCD28898688 | 95.0% | 279.29 g/mol | C14H17NO5 | 50 MG
SDP

Cyclooctyne-O-NHS ester is a cyclooctyne-containing N-hydroxysuccinimide (NHS) ester used as a cleavable ADC linker and click-chemistry reagent for bioconjugation. It undergoes azide-alkyne cycloaddition to enable antibody-drug conjugate construction, labeling, and related conjugation workflows.

  • Cleavable ADC linker for antibody-drug conjugate synthesis.
  • Reacts with azide groups via strain-promoted and copper-catalyzed azide-alkyne cycloaddition.
  • NHS ester chemistry enables efficient conjugation to primary amines.
  • Supplied as a solid in multiple pack sizes suitable for small-scale synthesis.
  • Datasheet and safety data sheet available for handling and storage guidance.

ENCOMPASS_PREFERRED
7

Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate | 107348-47-0 | MFCD28398150 | 98.0% | 326.40 g/mol | C13H14N2O4S2 | 50 MG
SDP

PPC-NHS ester is a cleavable linker reagent containing an N-hydroxysuccinimide (NHS) ester and a pyridin-2-yldisulfanyl cleavable moiety; it is used to attach cytotoxic payloads to antibodies and enable payload release under reducing conditions.

  • Cleavable disulfide linker enabling intracellular release of payloads
  • N-hydroxysuccinimide (NHS) ester reactive toward primary amines
  • Molecular formula C13H14N2O4S2, molecular weight 326.40 g/mol
  • Purity 98.0%
  • Supplied as a white to off-white solid, 50 MG per package
  • Storage: powder -20°C (stable 3 years); in solvent -80°C (6 months), -20°C (1 month)

ENCOMPASS_PREFERRED
8

Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[6-[[1-oxo-3-(2-pyridinyldithio)propyl] | 129179-83-5 | 99.7% | 539.78 | 50 MG
SDP

Biotin-HPDP is a biochemical reagent that can couple with GMPS and label free protein thiols. It is suitable for use as a biological material or organic compound for life science related research.

  • Couples with GMPS
  • Labels free protein thiols
  • Modified surfaces adsorb proteins

ENCOMPASS_PREFERRED
9

Medchemexpress LLC M-PEG-NHS ester (MW 10000) | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 50 MG
SDP

M-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs.

  • PEG-based PROTAC linker
  • Can be used in the synthesis of PROTACs

ENCOMPASS_PREFERRED
10

Medchemexpress LLC Carbonic acid, 1-[4-[(16-azido-PEG3)oxy]-5-methoxy-2-nitrophenyl]ethyl 2,5-dioxo-pyrrolidinyl ester | 1802907-96-5 | MFCD29052189 | 98.7% | 640.60 g/mol | C26H36N6O13 | 50 MG
SDP

PC Azido-PEG3-NHS carbonate ester is a photocleavable azido-PEG3 NHS carbonate linker for labeling primary amines on proteins, amine-modified oligonucleotides, and other amine-containing molecules. It combines an NHS carbonate reactive group with an azide handle and a photocleavable moiety to enable covalent labeling and light-triggered release. Supplied as a colorless to light-yellow oil for research use; follow manufacturer storage recommendations.

ENCOMPASS_PREFERRED
11

Medchemexpress LLC N-(4-aminobutyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 151294-96-1 | MFCD28397129 | 97.0% | 314.45 g/mol | C14H26N4O2S | 50 MG
SDP

Biotin-C4-amide-C5-NH2 is a cleavable antibody-drug conjugate (ADC) linker bearing a biotin tag and a primary amine for affinity capture and conjugation during ADC synthesis and analysis. Intended for research use only.

  • Cleavable ADC linker with biotin tag for affinity-based capture.
  • Primary amine enables conjugation to payloads or linkers.
  • High purity: 97.0% (typical).
  • Molecular weight 314.45 g/mol; formula C14H26N4O2S.
  • Storage: store at 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
  • For research use only; not for human therapeutic use.

ENCOMPASS_PREFERRED
12

TARGETMOL CHEMICALS INC NSP-SA-NHS 5MG
SDP

Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. NSP-SA-NHS is a chemiluminescent acridinium ester that can be used for immunoassays. Purity 98.42%

ENCOMPASS_PREFERRED
13

TARGETMOL CHEMICALS INC DOTA-NHS-ester 10MG
SDP

Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. DOTA-NHS-ester is a linker for affibody molecules with applications in small animal PET, SPECT, and CT. It can be used to label radiotherapeutic agents or imaging probes for tumor detection. Purity ≥98%

ENCOMPASS_PREFERRED
14

TARGETMOL CHEMICALS INC Biotin-azide 5MG
SDP

Also available in 1 mL, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Biotin-azide (N-(3-Azidopropyl)biotinamide) is used for preparing various biotin affixes and identifying proteins. Purity 99.69%

ENCOMPASS_PREFERRED
15

TARGETMOL CHEMICALS INC Cy3 NHS ester 5MG
SDP

Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Cy3 NHS ester is a fluorescent dye used to label amino groups in proteins, peptides, antibodies, and oligonucleotides. The excitation/emission (Ex/Em) values of Cy3 NHS ester are 550 nm/570 nm. Purity 98.03%

ENCOMPASS_PREFERRED