Furans
Medchemexpress LLC PF-04634817 succinate | 2140301-98-8 | 99.5% | 629.67 | C29H42F3N5O7 | 5 MG
PF-04634817 succinate is a research-grade small molecule dual CCR2/CCR5 chemokine receptor antagonist supplied as the succinate salt in a white to off-white solid. It is orally active in preclinical models, displays potent CCR2 activity (rat IC50 ≈ 20.8 nM) with lower CCR5 potency (rat IC50 ≈ 470 nM), and is intended for laboratory research use only.
- Dual CCR2/CCR5 antagonist activity (rat CCR2 IC50 ≈ 20.8 nM; CCR5 IC50 ≈ 470 nM).
- High purity (~99.5%).
- Supplied as a succinate salt in solid form.
- Molecular weight 629.67 Da.
- Intended for in vitro and in vivo research; not for human use.
- Available in 5 mg package size.
![eMolecules Apollo Scientific 6-Nitrobenzo[b]thiophene 1 1-dioxide 500mg 562447323 OR26006 95 000 19983-44-9 MFCD00173799 211 190 C8H5NO4S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules Apollo Scientific 6-Nitrobenzo[b]thiophene 1 1-dioxide 500mg 562447323 OR26006 95 000 19983-44-9 MFCD00173799 211 190 C8H5NO4S
Apollo Scientific 6-Nitrobenzo[b]thiophene 1 1-dioxide 500mg 562447323 OR26006 95 000 19983-44-9 MFCD00173799 211 190 C8H5NO4S
Medchemexpress LLC Paederosidic acid | 18842-98-3 | MFCD28124366 | 10 MG
Paederosidic acid, isolated from P. scandens, is a chemical compound exhibiting anticancer and anti-inflammation activities. It primarily acts by inducing mitochondria-mediated apoptosis in lung cancer cells.
- Inhibits lung cancer cells by inducing mitochondria-mediated apoptosis.
- Shows effects on NCI-H1650, HCC827, and A549 cells.
- Up-regulates caspase-3, caspase-8, caspase-9, Bid, Bax.
- Down-regulates Bcl-2.
- Stimulates Cyto-C release from mitochondria.
Medchemexpress LLC Dma-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 100 MG
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. It binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM) and has no significant toxicity in cell-based studies.
- Inhibits enterovirus 71 (EV71) IRES-dependent translation and replication
- Binds to EV71 SLII domain with moderate affinity (KD= 520 nM)
- No significant toxicity in cell-based studies
- Induces conformational changes in RNA structure
- Stabilizes DMA135-RNA-AUF1 ternary complex
- Inhibits EV71 with an IC50 of 7.54 μM
![Medchemexpress LLC 4-[2-(cyclopropylmethoxy)-5-(methylsulfonyl)phenyl]-2-methyl-1(2H)-isoquinolinone | 1706738-98-8 | >98.0% | C21H21NO4S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259395.png-250.jpg)
Medchemexpress LLC 4-[2-(cyclopropylmethoxy)-5-(methylsulfonyl)phenyl]-2-methyl-1(2H)-isoquinolinone | 1706738-98-8 | >98.0% | C21H21NO4S | 10MG
Trotabresib is an oral, potent, reversible small-molecule inhibitor of bromodomain and extra-terminal (BET) proteins. It is used in preclinical and clinical oncology research for advanced solid tumors and glioma and is supplied as a research-grade solid for translational studies.
- Oral, reversible BET inhibitor suitable for epigenetic research.
- Demonstrates antitumor activity in cell lines and xenograft models.
- High purity (typically >98%) for reliable experimental results.
- Solid powder form, soluble in common organic solvents such as DMSO.
- Applicable to preclinical and clinical translational studies in oncology.
Medchemexpress LLC 1-aminohydantoin hydrochloride | 2827-56-7 | MFCD02181047 | 98.0% | 151.55 | C3H6ClN3O2 | 250mg
1-Aminohydantoin hydrochloride (Standard) is the analytical standard of 1-Aminohydantoin hydrochloride (HY-Y0469) This product is intended for research and analytical applications 1-Aminohydantoin hydrochloride is a major metabolite of Nitrofurantoin (HY-A0090) in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat milk et al 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of 1-Aminohydantoin hydrochloride before detection[1][2]
Medchemexpress LLC Trotabresib | 1706738-98-8 | 99.7% | 383.46 | 100 MG
Trotabresib is a reversible and orally active BET inhibitor used in the study of advanced solid tumors. It inhibits the proliferation of diffuse midline glioma (DMG) cells and shows stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype.
- Reversible and orally active BET inhibitor
- Applied in studies for advanced solid tumors
- Inhibits proliferation of diffuse midline glioma (DMG) cells
- Shows stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype
![Medchemexpress LLC 2-[(2-carboxyphenyl)amino]-4-chlorobenzoic acid | 63329-53-3 | MFCD00866065 | 99.4% | 291.68 g/mol | C14H10ClNO4 | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237302.png-250.jpg)
Medchemexpress LLC 2-[(2-carboxyphenyl)amino]-4-chlorobenzoic acid | 63329-53-3 | MFCD00866065 | 99.4% | 291.68 g/mol | C14H10ClNO4 | 50MG
Lobenzarit is a small-molecule immunomodulator used in preclinical research that has reported anti-oxidative and anti-inflammatory properties. It is supplied as a high-purity research reagent (CAS 63329-53-3) and is used in vitro and in vivo to study immune modulation and anti-arthritic effects.
- High purity suitable for research use.
- Reported immunomodulatory and anti-oxidative activity.
- Available in multiple small-scale sizes for preclinical studies.
- Stable when stored under recommended conditions (powder and in solvent).
- Molecular formula C14H10ClNO4; molecular weight 291.68 g/mol.
eMolecules 3-ETHYNYLTETRAHYDRO-2H-PYRAN | 1260667-24-0 | MFCD18250569 | 1g
AstaTech | 3-ETHYNYLTETRAHYDRO-2H-PYRAN | 1g | 391060138 | P12240 | 95.000 | 1260667-24-0 | MFCD18250569 | 110.156 | C7H10O
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Medchemexpress LLC Chdi-390576 | 1629729-98-1 | 98.1% | 25 MG
This small-molecule class IIa histone deacetylase (HDAC) inhibitor is reported to be cell-permeable and to penetrate the central nervous system. It is supplied in research pack sizes and analytical formats, with molecular formula C19H13F4N3O2, molecular weight 391.32 g/mol, and reported purity 98.10%.
- Potent inhibition of class IIa HDACs (IC50s: 54 nM, 60 nM, 31 nM, 50 nM).
- Cell permeable and CNS penetrant.
- Available in multiple pack sizes and solution formats.
- High reported purity suitable for research assays.
- Analytical documentation available (COA, SDS, HNMR, LCMS, RP-HPLC).
Medchemexpress LLC DS08210767 | 2376334-75-5 | 99.4% | 513.67 | C31H39N5O2 | 5MG
DS08210767 is a small-molecule, orally bioavailable antagonist of the parathyroid hormone receptor 1 (PTHR1) with a reported IC50 of 90 nM. It is supplied for research use only and is provided as a light yellow solid intended for laboratory applications.
- Orally bioavailable PTHR1 antagonist with an IC50 of 90 nM.
- High chemical purity of 99.4%.
- Molecular weight 513.67 and chemical formula C31H39N5O2.
- Supplied as a light yellow solid suitable for laboratory research.
- Provided in a 5 mg quantity for experimental use.
![Medchemexpress LLC 2-(2-fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide | 1629729-98-1 | 98.1% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234654.png-250.jpg)
Medchemexpress LLC 2-(2-fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide | 1629729-98-1 | 98.1% | 50 MG
CHDI-390576 is a potent, cell-permeable, CNS-penetrant small-molecule inhibitor selective for class IIa histone deacetylases (HDAC4, HDAC5, HDAC7, HDAC9). It is provided as a high-purity research compound for biochemical and cellular studies of HDAC function and selectivity.
- Low-nanomolar inhibitory activity against class IIa HDAC isoforms (reported IC50s: HDAC4 54 nM, HDAC5 60 nM, HDAC7 31 nM, HDAC9 50 nM).
- High selectivity against class I HDACs and over HDAC8 and HDAC6.
- CNS penetrant and cell permeable for central nervous system research.
- High purity suitable for biochemical and cellular assays.
- Molecular formula C19H13F4N3O2; molecular weight 391.32.
Medchemexpress LLC 1-aminohydantoin hydrochloride | 2827-56-7 | MFCD02181047 | >98.0% | 151.55 | C3H6ClN3O2 | 1g
1-Aminohydantoin hydrochloride is a major metabolite of Nitrofurantoin (HY-A0090) in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat milk et al 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of 1-Aminohydantoin hydrochloride before detection[1][2]
Medchemexpress LLC C-021 | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 5 MG
C-021 is a small-molecule antagonist of the CC chemokine receptor 4 (CCR4) used for research into GPCR signaling and immunology. It inhibits CCR4-mediated chemotaxis in human and mouse systems and is supplied as a solid for laboratory studies.
- Target CCR4.
- Molecular formula C27H41N5O2.
- Molecular weight 467.65 g/mol.
- Purity 99.95%.
- Appearance solid, off-white to light yellow.
- Storage powder: -20°C (up to 3 years); in solvent: -80°C (short-term).
- Supplied in small research quantities.
Medchemexpress LLC TCS PrP Inhibitor 13 25mg | 34320-83-7 | 25MG
TCS PrP Inhibitor 13 an antiprion agent is a cellular prion protein (PrPC) inhibitor TCS PrP Inhibitor 13 as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor shows an IC50 value of 3 nM in both ScN2a and F3 cell lines TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1