Lactams
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.26% | 388.37 | 100 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, which is the final step intermediate in the synthesis of Thalidomide-4-OH. It acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. It is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
- Acts as a Cereblon ligand to recruit CRBN proteins.
- The t-Bu protecting group can be removed under acidic conditions to participate in the synthesis of PROTAC molecules.
- Key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 1 G
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative (5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione) described as an E3 ligase activator. It is provided as a research chemical for use as a biochemical probe, synthetic building block, or starting material for further derivatization.
- Acts as an E3 ligase activator useful in targeted protein degradation studies.
- Contains a fluorine atom enabling SNAr reactions and further derivatization.
- Supplied in small-quantity packages suitable for research and synthesis.
- Well-defined chemical identity with CAS 2230957-36-3.
- Chemical formula C14H11FN2O4 and molecular weight 290.25.
Medchemexpress LLC Thalidomide-NH-C10-NH2 hydrochloride | 2460022-53-9 | 464.99 | C23H33ClN4O4 | 10 MG
Thalidomide-NH-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt in solid form for research use. It is intended for incorporation into PROTACs and other E3 ligase recruiting conjugates for chemical biology and medicinal chemistry studies.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Suitable for PROTAC construction and linker conjugation.
- Provided as a solid hydrochloride salt for stability and handling.
- Available in small milligram packages appropriate for synthesis and assays.
- Store sealed, away from moisture and light; follow supplier storage guidance.
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00078028 | 99.98% | 258.23 | 500 MG
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of approximately 250 nM. It possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. Thalidomide can also function as a molecular glue to potentiate substrate.
- Inhibits cereblon (CRBN), a component of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
- Demonstrates immunomodulatory, anti-inflammatory, and anti-angiogenic properties.
- Functions as a molecular glue to potentiate substrate.
- Potentiates the anti-tumor activity of Icotinib against PC9 and A549 cell proliferation.
- Inhibits EGFR and VEGF-R2 pathways in PC9 cells.
- Alleviates RILF by suppressing ROS and down-regulating the TGF-β/Smad pathway.
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 | 25 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker
- Forms PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 100.0% | 312.28 | 50 MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand utilized in the recruitment of CRBN protein. It can be linked to a ligand for protein via a linker to create IMiD-containing PROTACs. This product is also a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to ligands for protein to form IMiD containing PROTACs
- Click chemistry reagent
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide groups
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 96.0% | C24H31N3O7 | 25 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
- Targets cereblon
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 500 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide that functions as a cereblon (CRBN) E3 ligase ligand for chemical biology and targeted protein degradation research. Identifiers: CAS 2222115-19-5; formula C13H8F2N2O4; molecular weight 294.21 g/mol. It is supplied as a research-grade solid with reported purity around 98.0%.
- Fluorinated analogue used as a cereblon E3 ligase ligand.
- Enables recruitment of CRBN for targeted protein degradation studies.
- Amenable to further derivatization via substitution at fluorine positions.
- High chemical purity (approximately 98.0%).
- Provided as a solid powder for research and analytical applications.
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 98.0% | 353.76 g/mol | C15H16ClN3O5 | 10 MG
Thalidomide-5-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt. It is used as an E3 ligase ligand-linker conjugate in targeted protein degradation research and PROTAC synthesis, enabling the attachment of linkers or functional groups to the thalidomide scaffold for chemical biology applications.
- High reported purity, 98.0%.
- Supplied as the hydrochloride salt for improved handling.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable for PROTAC synthesis and ligand-linker conjugation.
- Characterized by CAS 2694727-89-2 and molecular weight 353.76 g/mol.
- Available in small research pack sizes such as 10 MG.
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | 634.67 | C30H42N4O11 | 5 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate containing a PEG3 spacer and a Boc-protected terminal amine. Supplied as a white to off-white solid at high purity, it is designed for use as a building block in PROTAC synthesis and targeted protein degradation research, enabling modular assembly of cereblon-recruiting degraders.
- Thalidomide-based cereblon ligand useful for recruiting E3 ligase.
- Peg3 linker provides a flexible spacer for conjugation to target ligands.
- Boc-protected terminal amine enables orthogonal deprotection and coupling chemistry.
- High purity suitable for synthetic and medicinal chemistry applications.
- Available in small-mass pack sizes for discovery and early-stage research.
Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.6% | 380.78 | 250 MG
Thalidomide-5-PEG2-Cl is a Thalidomide-based cereblon ligand that plays a crucial role in recruiting CRBN protein. It can be utilized to form PROTACs by linking to a target protein ligand. PROTACs are designed to selectively degrade target proteins within the intracellular ubiquitin-proteasome system by exploiting E3 ubiquitin ligase and target protein interactions.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be linked to form PROTACs
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-5-O-C13-NH2 (hydrochloride) | 99.9% | 508.05 | 5 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a cereblon ligand based on Thalidomide. It is utilized in the recruitment of CRBN protein and can be connected to a protein ligand by a linker to form PROTACs.
- Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker
- Forms PROTACs
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 100 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, designed for use in PROTAC technology. PROTACs function by connecting two ligands: one for an E3 ubiquitin ligase and another for a target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Designed for PROTAC technology applications
- Selectively degrades target proteins via ubiquitin-proteasome system
- Off-white to light yellow solid
- Soluble in DMSO at ≥ 100 mg/mL
![eMolecules 73804-69-0 | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | MFCD08457561 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502136107.JPG-250.jpg)
eMolecules 73804-69-0 | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | MFCD08457561 | 1g
Pharmablock | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | 1g | 551143363 | PBN20122091-1 | 73804-69-0 | MFCD08457561 | 163.600 | C6H10ClNO2
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