Lactams
eMolecules BENZYL 5-(TERT-BUTYLDIMETHYLSILYLOXY)PENTYLCARBAMATE | 699020-11-6 | MFCD23378614 | 1g
AstaTech | BENZYL 5-(TERT-BUTYLDIMETHYLSILYLOXY)PENTYLCARBAMATE | 1g | 402180213 | 21198 | 95.000 | 699020-11-6 | MFCD23378614 | 351.562 | C19H33NO3Si
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | 945.09 g/mol | C44H64N8O13S | 5 MG
Biotin-Thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied for research use in target engagement studies and PROTAC synthesis. It is provided as a high-purity chemical probe for biochemical assays, affinity capture, and conjugation workflows; not for human therapeutic use.
- High purity (≈99.7%) suitable for research applications
- Cereblon-binding probe useful for PROTAC development
- Biotin tag enables affinity capture and pull-down assays
- Compatible with conjugation and synthetic workflows
- Intended for research use only
Cayman Chemical -ThalIdomIde 1g
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | C25H36ClN5O9 | 5 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG4-C2 spacer. Supplied as the hydrochloride salt in solid form and reported at high purity, the compound is intended as a building block for PROTAC design and other CRBN-recruiting chemical biology applications.
- E3 ligase ligand-linker conjugate for PROTAC construction.
- Includes a thalidomide-based cereblon ligand to recruit CRBN proteins.
- PEG4-C2 linker with terminal amine for facile conjugation.
- Hydrochloride salt form to aid handling and solubility.
- High purity suitable for synthetic and research workflows.
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.
- Provides CRBN engagement via a thalidomide-derived ligand.
- Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
- Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Characterized by analytical data, including HPLC, LC-MS, and NMR files.
- Available in small research-scale quantities for medicinal chemistry applications.
Selleck Chemical LLC Thalidomide 200mg 50-35-1
Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Thalidomide-5-peg2-cl | 2230956-57-5 | 96.6% | 380.78 g/mol | C17H17ClN2O6 | 5 MG
Thalidomide-5-PEG2-Cl is a thalidomide-derived cereblon ligand intended for use as the E3 ligase-recruiting component in proteolysis-targeting chimera (PROTAC) synthesis. It contains a two-unit polyethylene glycol linker and a terminal chloro functional group to facilitate conjugation to target ligands. Intended for research use only.
- Enables cereblon recruitment in PROTAC constructs.
- Contains a PEG2 linker for flexible conjugation.
- Terminal chloro group for facile chemical coupling.
- High purity suitable for research applications.
- Available in small milligram quantities for screening and synthesis.
Cell Signaling Technology Phospho-IKK-epsilon (Ser172) (D1B7) Rabbit mAb 20 ul
Phospho-IKK-epsilon (Ser172) (D1B7) Rabbit mAb 20 ul
eMolecules AstaTech / (S)-3-((TERT-BUTYLDIMETHYLSILYL)OXY)PYRROLIDIN-2-ONE / 0.25g / 296387864 / W11603 / 95.000 / 130403-91-7 / MFCD26394938 / 215.368 / C10H21NO2Si
AstaTech / (S)-3-((TERT-BUTYLDIMETHYLSILYL)OXY)PYRROLIDIN-2-ONE / 0.25g / 296387864 / W11603 / 95.000 / 130403-91-7 / MFCD26394938 / 215.368 / C10H21NO2Si
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 1 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as an E3 ligase recruiting moiety in chemical biology and PROTAC research. It is supplied as a powder and as a 10 mM DMSO solution for laboratory use.
- High purity: 99.96%
- Molecular weight: 276.22 g/mol
- Chemical formula: C13H9FN2O4
- Available sizes: 1 mL (10 mM in DMSO), 1 G, 5 G, 10 G, 25 G, 50 G
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
- Safety and quality documents: SDS and COA provided by manufacturer
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.