Lactams
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | 100 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. For research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-4-O-C11-NH2 hydrochloride | 99.9% | 480.00 g·mol⁻¹ | C24H34ClN3O5 | 10 MG
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation and PROTAC development. It is intended as an E3 ligase ligand-linker conjugate for synthesis and biochemical studies involving CRBN recruitment.
- High purity (99.94%) suitable for synthetic applications.
- Hydrochloride salt form for improved handling and solubility.
- Molecular formula C24H34ClN3O5; molecular weight 480.00 g·mol⁻¹.
- Available in small mg-scale pack sizes for research workflows.
- Designed for use as a cereblon ligand in PROTAC design and E3 ligase recruitment studies.
Medchemexpress LLC Thalidomide-Propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 | 25 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. It is a click chemistry reagent, containing an alkyne group, and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc).
Medchemexpress LLC CD3 epsilon protein (rat, HEK293-expressed, Fc tag) | ≥95.0% | 100 UG
Recombinant rat CD3 epsilon protein expressed in HEK293 cells with a C-terminal Fc tag, purified to ≥95% and supplied for use in immunoassays, binding studies, and antibody characterization.
- Recombinant rat CD3 epsilon (Y24-D103).
- Expressed in HEK293 cells for mammalian post-translational modifications.
- C-terminal Fc tag for improved stability and detection.
- Purity ≥95.0% as determined by supplier analysis.
- Supplied in a 100 μg format suitable for assay development.
- Common applications include TCR binding assays and antibody validation.
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 50 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a linker. This product can be used for the synthesis of PROTAC BET degrader.
- E3 ligase ligand-linker conjugate
- Thalidomide based cereblon ligand
- PROTAC BET degrader synthesis
- Inhibitor
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 25 MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form IMiD-containing PROTACs. This compound is also a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Cereblon ligand
- Recruits CRBN protein
- Forms IMiD-containing PROTACs
- Click chemistry reagent
- Features an Alkyne group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Aztreonam | 78110-38-0 | MFCD00072145 | 99.6% | 435.43 | C13H17N5O8S2 | 10 MG
Aztreonam (standard) is an analytical reference material containing the monobactam antibiotic aztreonam. Provided at high purity, it is intended for analytical testing, assay calibration, method validation, and quality control in pharmaceutical and biochemical laboratories.
- Analytical reference standard for aztreonam.
- High purity suitable for assay and quality control work.
- Available in small precision pack sizes for analytical use.
- Reported molecular weight 435.43 and formula C13H17N5O8S2.
- Includes CAS number 78110-38-0 for unambiguous identification.
Cambridge Isotope Laboratories N-METHYLCAPROLACTAM (N-METHYL-D3, 98%), 5 G
N-METHYLCAPROLACTAM (N-METHYL-D3, 98%), 5 G
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 25 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a cereblon (CRBN) ligand in the synthesis of PROTAC degraders and other bifunctional molecules. It is supplied as an off-white to gray solid with high purity for research use.
- High purity: 98.0%.
- Molecular weight: 335.74 g/mol.
- Molecular formula: C15H14ClN3O4.
- CAS number: 2616553-35-4.
- Physical form: off-white to gray solid.
- Storage: store dry and keep cool; in solution store at -80°C (2 years) or -20°C (1 year).
- Applications: used as an E3 ligase ligand for PROTAC synthesis.
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 g/mol | C27H40ClN3O5 | 10 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied for research use in targeted protein degradation and PROTAC development. It is provided as a small-quantity, high-purity solid suitable for conjugation through linkers to build bifunctional degraders and other CRBN-recruiting constructs.
- High purity of 97.7%.
- Molecular weight 522.08 g/mol and chemical formula C27H40ClN3O5.
- White to off-white solid appearance.
- Storage recommendations: -20 °C; in solvent: -80 °C (6 months) or -20 °C (1 month), protect from light, store under nitrogen.
- Suitable for use as a CRBN-recruiting ligand in PROTAC synthesis.
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 50 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.