Lactams
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
![Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259722.png-250.jpg)
Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG
Thalidomide-4-O-C10-COOH is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate provided for research use as a synthetic intermediate in the preparation of proteolysis-targeting chimeras (PROTACs). The molecule features a ten-carbon linker terminating in a carboxylic acid, and is supplied as a solid with formula C24H30N2O7 and molecular weight 458.50 g·mol⁻¹.
- Thalidomide-based cereblon (CRBN) ligand-linker conjugate.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Contains a C10 linker with a terminal carboxylic acid for conjugation.
- High reported purity (99.1%).
- Supplied as a solid; molecular formula C24H30N2O7, molecular weight 458.50 g·mol⁻¹.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 50 MG
Thalidomide-NH-C4-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based cereblon ligand and a linker, used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Targets cereblon
- Solid appearance
- Color: yellow to green
- For research use only
Medchemexpress LLC Thalidomide-5-O-C3-NH2 hydrochloride | 2694727-94-9 | MFCD34475114 | 99.1% | 367.78 g/mol | C16H18ClN3O5 | 10 MG
Thalidomide-5-O-C3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use as a building block in targeted protein degradation research and PROTAC design. It is provided as a solid with supporting analytical data for research use.
- Acts as a cereblon-binding ligand for CRBN recruitment.
- Enables linker conjugation for PROTAC assembly.
- Supplied with high purity (99.08%).
- Provided as a solid suitable for long-term storage under recommended conditions.
- Analytical data and COA available to support research use.
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 10MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate supplied as a solid for research use. The compound features a PEG3 linker and a Boc-protected terminal amine, offered with high reported purity and characterized molecular data, suitable as a synthetic intermediate in chemical biology and PROTAC development.
- High reported purity suitable for synthesis and analysis.
- Characterized molecular formula and molecular weight for experimental planning.
- Boc-protected terminal amine enables selective deprotection and conjugation.
- PEG3 linker provides flexibility and improved solubility in conjugates.
- Available in small milligram quantities for research workflows.
Medchemexpress LLC HY-126457 5mg Medchemexpress, Thalidomide-propargyl CAS:2098487-39-7 Purity:>98%
Medchemexpress, HY-126457 5mg Thalidomide-propargyl CAS:2098487-39-7 Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Thalidomide-5-CH2-NH2 hydrochloride | 1010100-22-7 | MFCD32666042 | 98.6% | 323.73 | C14H14ClN3O4 | 50 MG
Thalidomide-5-CH2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC design and targeted protein degradation research. Supplied as a solid with high purity, it serves as a linker-compatible building block for medicinal chemistry and chemical biology applications.
- High purity suitable for research.
- Solid form, easy to handle and store.
- Compatible with linker conjugation for PROTAC synthesis.
- Facilitates CRBN-mediated target recruitment.
- Available in multiple small pack sizes for synthesis workflows.
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | >98.0% | 311.29 g/mol | C16H13N3O4 | 100 MG
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate bearing a terminal alkyne for click-style conjugation, supplied for research use in small packs for assembling PROTACs and other bioconjugates.
- Contains a terminal alkyne for click conjugation.
- Functions as an E3 ligase ligand suitable for PROTAC assembly.
- Purity >98.0%.
- Molecular formula C16H13N3O4; molecular weight 311.29 g/mol.
- CAS number 2357110-24-6 for substance identification.
- Supplied as a 100 mg research pack.
- For research use only; not for human or animal therapeutic use.
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | MFCD31560486 | ≥98.0% | 428.40 g·mol⁻¹ | C19H20N6O6 | 5 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate that contains an azide functional group. It is supplied as a research-grade building block for the design and synthesis of proteolysis-targeting chimeras (PROTACs) and for click-chemistry bioconjugation, compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted azide-alkyne cycloaddition.
- Contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Research-grade building block with defined molecular formula and molecular weight.
- Forms a clear solution when dissolved in common organic solvents.
- Recommended storage: store solid at 4°C under inert atmosphere; in solution -80°C for up to 6 months or -20°C for up to 1 month.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 440.88 g·mol⁻1 | C19H25ClN4O6 | 5 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the hydrochloride salt for research use. It combines a thalidomide cereblon-binding moiety with a two-unit polyethylene glycol spacer and a C2 amino termination, designed for incorporation into PROTAC constructs and linker chemistry in targeted protein degradation studies.
- Provides a thalidomide-derived cereblon binding motif suitable for E3 ligase recruitment.
- Contains a PEG2 spacer to improve solubility and linker flexibility.
- Terminates in a C2 amino handle for straightforward conjugation chemistry.
- Supplied as the hydrochloride salt for enhanced stability and handling.
- Characterized with reported molecular weight and purity for research applications.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.29% | 50 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, which is used in PROTAC (Proteolysis-Targeting Chimera) technology. This compound is intended for research use only.
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Composed of two different ligands connected by a linker
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 g/mol | C13H9IN2O4 | 250 MG
Thalidomide-iodo is an iodinated derivative of thalidomide that functions as an E3 ligase activator for chemical biology and medicinal chemistry research. It is supplied as a solid research reagent and can be used as a synthetic building block for further derivatization via substitution of the iodine atom.
- Iodinated thalidomide derivative suitable for E3 ligase activation studies.
- Useful as a synthetic building block for iodine substitution and derivatization.
- High purity (≥98.0%) appropriate for research applications.
- Molecular weight 384.13 g/mol; formula C13H9IN2O4.
- CAS number 2509137-01-1 for unambiguous identification.
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 704.72 | 100 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g·mol⁻1 | C19H21BN2O6 | 25 MG
Thalidomide-pinacolborane is a thalidomide-derived boronic pinacol ester used as a cereblon (CRBN) ligand for E3 ligase recruitment in PROTAC design and for synthetic transformations such as Suzuki cross-coupling. It is supplied as a solid research reagent intended for use in ligand design, chemical synthesis, and targeted protein degradation studies.
- Contains boronic pinacol ester (Bpin) functionality for Suzuki coupling.
- Functions as a cereblon E3 ligase ligand suitable for PROTAC applications.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g·mol⁻1.
- CAS number 2229725-98-6.
- Purity 97.0% as listed by the supplier.
- Provided as a 25 MG research pack.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | 100 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. For research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins