Lactams
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
eMolecules 1061605-21-7 | Thalidomide-O-C1-acid | Broadpharm332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Thalidomide-O-C1-acid | Broadpharm | 1061605-21-7332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 50 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- Utilized in PROTAC technology.
- Exploits intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Targets Cereblon.
- For research use only.
Medchemexpress LLC Thalidomide-piperazine 5-fluoride hydrochloride | 2222114-23-8 | MFCD32203462 | 98.9% | 396.80 g/mol | C17H18ClFN4O4 | 5 G
Thalidomide-piperazine 5-fluoride hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ubiquitin ligase ligand supplied as the hydrochloride salt for research use. It is a light-yellow solid with high reported purity and is intended for use in PROTAC synthesis and related chemical biology applications.
- Used as a ligand for cereblon (CRBN) in PROTAC synthesis.
- High purity (98.9%) suitable for research applications.
- Provided as a hydrochloride salt for improved handling.
- Light yellow solid form for easy weighing and storage.
- Storage: room temperature; in solvent, -80°C (2 years) or -20°C (1 year).
- Available in multiple package sizes including gram-scale quantities.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | 40313-92-6 | 99.9% | 272.26 | 25 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand derived from Thalidomide, used for recruiting CRBN protein. It can be utilized in the synthesis of PROTACs.
- Thalidomide-based cereblon (CRBN) ligand.
- Used in the recruitment of CRBN protein.
- Can be used to synthesize PROTACs.
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | MFCD34180776 | 99.4% | 355.12 g·mol⁻1 | C13H8BrFN2O4 | 25 MG
Thalidomide-4-F,5-Br is a halogenated thalidomide analogue that functions as an E3 ligase recruiting ligand for targeted protein degradation research. Supplied as a powder in small pre-weighed quantities, it is intended for research use in PROTAC development and studies of ubiquitin-mediated proteolysis.
- Halogenated thalidomide derivative (fluoro and bromo substitutions).
- Acts as a cereblon (CRBN) E3 ligase recruiting ligand for PROTAC applications.
- High purity suitable for research (approximately 99.4%).
- Provided as a powder for easy handling and formulation.
- Available in small pre-weighed quantities for screening and synthesis workflows.
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | 99.9% | 272.26 | 50 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand, based on Thalidomide, used in the recruitment of CRBN protein. It can be utilized for the synthesis of PROTACs and is intended for research use only.
- Cereblon (CRBN) ligand
- Recruits CRBN protein
- Utilized for PROTAC synthesis
- Molecular weight: 272.26
- Solid appearance, gray to gray purple color
- Soluble in DMSO (50 mg/mL with warming)
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-NH-C10-COOH | 2428400-33-1 | 97.5% | 100 MG
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. It has a molecular weight of 457.52 and the formula C24H31N3O6. It appears as a light yellow to yellow solid. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based CRBN ligand
- Used in PROTAC technology
- Molecular weight: 457.52
- Formula: C24H31N3O6
- Appearance: Light yellow to yellow solid
- Purity: 97.5%
- Target: Cereblon
- Solubility in DMSO: 50 mg/mL (109.28 mM)
Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.
- Enables CRBN engagement via a thalidomide-derived ligand.
- Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
- High reported purity enables reliable analytical and synthetic work.
- Solid, white-to-yellow appearance for easy handling and storage.
- Recommended storage at -20°C under inert gas to preserve integrity.
- Available in small milligram quantities suitable for early-stage research.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 100 MG
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand designed for recruiting CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs, making it suitable for research use in laboratory chemical manufacturing. This substance is stable under recommended storage conditions and is not classified as a hazardous substance or mixture.
- Used to recruit CRBN protein
- Can be linked to a target protein ligand via a linker to form PROTACs
- Suitable for laboratory chemical manufacturing
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
- Recommended storage temperature: -20°C, stored under nitrogen
- Molecular formula: C26H34N2O7
- Molecular weight: 486.56
- Appearance: Solid, white to off-white
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 97.0% | 290.25 g/mol | C14H11FN2O4 | 5 G
A fluorinated thalidomide analogue that functions as an E3 ligase (Cereblon) activator and a synthetic building block for targeted protein degradation research. Suitable for recruiting CRBN in PROTAC design and for further chemical derivatization via nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue
- Acts as an E3 ligase (Cereblon) activator
- Useful as a PROTAC ligand building block
- Compatible with SNAr derivatization
- Typical purity approximately 97.0%
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 100 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide supplied for laboratory research. It promotes protein ubiquitinylation and serves as a cereblon-binding ligand; the fluorine substitutions allow further chemical derivatization. Intended for scientific research use only.
- Fluorinated thalidomide analogue enabling further derivatization.
- Promotes ubiquitinylation and binds cereblon for E3 ligase recruitment.
- High purity (98.0%) suitable for research applications.
- Available in multiple package sizes from 25 mg to 10 g.
- White to off-white solid, suitable for storage and handling.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years).