Lactams
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g·mol⁻¹ | C13H10N2O5 | 10 G
Thalidomide-4-OH is a 4-hydroxylated metabolite of thalidomide used as a Cereblon (CRBN) ligand in chemical biology and PROTAC research. It is supplied as a high-purity solid for synthetic and biochemical applications, with recommended storage under inert atmosphere.
- High purity suitable for synthesis and assays.
- Molecular formula C13H10N2O5; molecular weight 274.23 g·mol⁻¹.
- Used as a CRBN ligand for recruitment of cereblon in PROTACs.
- Available in gram-scale quantities for research workflows.
- Solid with melting point 273-275 °C.
- Recommended storage: 4 °C under nitrogen; in solvent: -80 °C (6 months) or -20 °C (1 month).
Selleck Chemical LLC Tazobactam S3077-500mg
Tazobactam (Tazobactam acid Tazobactamum) is a -lactamases Inhibitor with antibacterial activity It also inhibits the class D oxacillinase OXA-2 It is used in combination with piperacillin and other -lactam antibiotics to broaden their spectrum and enhance their effect
Medchemexpress LLC Thalidomide-4-O-C10-COOH | 2379870-45-6 | MFCD03424822 | 99.1% | 458.50 g·mol⁻¹ | C24H30N2O7 | 5 MG
Thalidomide-4-O-C10-COOH is an E3 ligase ligand-linker conjugate intended as a building block for PROTAC synthesis. It features a thalidomide-derived cereblon-recruiting motif linked via a C10 spacer to a terminal carboxylic acid, allowing standard coupling chemistry for attachment to target-binding ligands. Supplied as a high-purity solid for laboratory research use.
- High purity suitable for synthesis work.
- Carboxylic acid terminus for standard coupling reactions.
- Contains a C10 spacer to provide linker flexibility.
- Molecular formula: C24H30N2O7; molecular weight: 458.50 g·mol⁻¹.
- Supplied in small mg-scale quantities appropriate for research.
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | MFCD32694133 | 548.59 g·mol-1 | C26H36N4O9 | 10 MG
Thalidomide-NH-PEG3-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate bearing a three-unit polyethylene glycol spacer and a Boc-protected terminal amine. It is provided as a synthetic intermediate for medicinal chemistry and chemical biology applications, especially for constructing cereblon-recruiting PROTACs.
- Boc-protected terminal amine for controlled deprotection and conjugation.
- PEG3 spacer offers flexibility and improved solubility for bifunctional molecules.
- Designed as an intermediate for CRBN-targeting PROTAC synthesis.
- Soluble in DMSO and compatible with standard in vivo formulation protocols.
- Store frozen to maintain stability.
eMolecules Synthonix / (S)-3-((tert-butyldimethylsilyl)oxy)-2-methylpropan-1-ol / 100mg / 794076249 / AC80921 / / 105859-45-8 / MFCD04039462 / 204.385 / C10H24O2Si
Synthonix / (S)-3-((tert-butyldimethylsilyl)oxy)-2-methylpropan-1-ol / 100mg / 794076249 / AC80921 / / 105859-45-8 / MFCD04039462 / 204.385 / C10H24O2Si
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 95.6% | 465.97 | C23H32ClN3O5 | 5 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand provided as a hydrochloride salt for use in PROTAC construction and chemical biology research. Supplied as a research reagent, it is intended for laboratory applications and not for human use.
- Cereblon ligand suitable for E3 ligase recruitment in PROTACs and degrader design.
- Hydrochloride salt improves solubility and handling compared with the free base.
- Reported purity approximately 95.6% as supplied.
- Molecular formula C23H32ClN3O5 and molecular weight 465.97.
- Available in small research pack sizes, for example 5 mg.
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | C17H20ClN3O5 | 10MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a C4 amine-containing linker for use in PROTAC development and targeted protein degradation research. Supplied as a hydrochloride salt and intended for research use only.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for biochemical and cell-based assays.
- Molecular formula C17H20ClN3O5; molecular weight 381.81 g·mol⁻¹.
- Available in small milligram quantities for discovery research.
- Storage: sealed at 4°C; in solution, -80°C for long-term storage.
Selleck Chemical LLC Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3 E3 ligase Ligand 3) a Thalidomide-based Cereblon (CRBN) ligand is used in the recruitment of CRBN protein Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera)