Lactams
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 50 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- Utilized in PROTAC technology.
- Exploits intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Targets Cereblon.
- For research use only.
Medchemexpress LLC 1H-isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 500 MG
Thalidomide-iodo is an iodinated derivative of thalidomide used as an E3 ligase (cereblon) activator for research applications. It is intended as a building block and synthetic intermediate for further derivatization by substitution of the iodine atom.
- E3 ligase activator (cereblon ligand) for targeted protein degradation research.
- Suitable as a synthetic intermediate for iodide substitution and further derivatization.
- High purity: 98.0% (NMR).
- Molecular formula C13H9IN2O4; molecular weight 384.13.
- CAS number 2509137-01-1.
- Appearance: gray to dark gray solid.
- Storage: 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Acy-957 | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 50 MG
ACY-957 is an orally active, selective small-molecule inhibitor of histone deacetylase isoforms HDAC1 and HDAC2, used for research into epigenetic regulation. It shows potent activity against HDAC1 and HDAC2, reduced activity against HDAC3, and no measurable inhibition of several class II HDACs. The compound is supplied as a high-purity solid and is available in solution formats for assay use.
- Potent inhibition of HDAC1 and HDAC2.
- High selectivity over HDAC3 and class II HDACs.
- Suitable for in vitro and in vivo formulation protocols.
- High reported purity for reliable experimental results.
- Provided as a solid and as ready-to-use DMSO solutions.
- Documented storage and stability conditions for sample handling.
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (TFA) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 1 G
Thalidomide-O-amido-C4-NH2 (TFA) is a thalidomide-derived cereblon ligand supplied as the trifluoroacetate salt and intended as a building block for E3 ligase ligand-linker conjugates and PROTAC research. The compound is provided as a solid research reagent with characterized purity, formula, and solubility data for in vitro and in vivo formulation.
- Intended for research use only.
- High purity 99.92%.
- Molecular weight 516.42 g/mol.
- Molecular formula C21H23F3N4O8.
- Soluble in DMSO (~42.86 mg/mL); multiple in vivo formulation protocols reported.
- Store dry at 4°C; in solvent store at -80°C for up to 6 months.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 25 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified thalidomide that functions as a Cereblon ligand, recruiting CRBN proteins. This compound serves as a final intermediate in the synthesis of Thalidomide-4-OH. Its t-Bu protecting group can be removed under acidic conditions, making it suitable for participation in PROTAC molecule synthesis and a key intermediate for CRBN-based designed PROTAC molecules.
- t-Bu modified thalidomide
- Intermediate in Thalidomide-4-OH synthesis
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group is removable under acidic conditions
- Key intermediate for CRBN-based PROTAC molecule synthesis
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 50 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that integrates a Thalidomide-based cereblon ligand with a linker used in PROTAC technology. This compound is intended for research use only.
- Acts as a click chemistry reagent due to its Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 g/mol | C27H40ClN3O5 | 10 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied for research use in targeted protein degradation and PROTAC development. It is provided as a small-quantity, high-purity solid suitable for conjugation through linkers to build bifunctional degraders and other CRBN-recruiting constructs.
- High purity of 97.7%.
- Molecular weight 522.08 g/mol and chemical formula C27H40ClN3O5.
- White to off-white solid appearance.
- Storage recommendations: -20 °C; in solvent: -80 °C (6 months) or -20 °C (1 month), protect from light, store under nitrogen.
- Suitable for use as a CRBN-recruiting ligand in PROTAC synthesis.
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 50 MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 10 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a 2-unit PEG linker, making it suitable for PROTAC technology applications. This product is for research use only.
- Used in PROTAC technology
- Suitable for autophagy research
- Applicable for apoptosis studies
- E3 ligase ligand-linker conjugate
- Targets cereblon
- Relevant for cancer targeted therapy research
- Used in cancer metabolism and metastasis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 25 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Targets cereblon
- Molecular weight: 444.48
- Chemical formula: C22H28N4O6
- Appearance: Solid
- Color: Yellow to green
- Solubility in DMSO: 100 mg/mL (224.98 mM)
- Shipping at room temperature in continental US
- Storage at 4°C, protected from light
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (protected from light)
Medchemexpress LLC Thalidomide-NH-C6-NH-Boc | 2093536-13-9 | 96.1% | 250 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker that was utilized in the synthesis of MI-389 (compound 22). MI-389 is recognized as a potent phthalimide PROTAC degrader, derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A). This product is intended for research use only and is not sold to patients.
- E3 ligase ligand-linker conjugate: contains a Thalidomide-based cereblon ligand.
- PROTAC component: the linker is used in the synthesis of MI-389, a potent phthalimide PROTAC degrader.
- Research use only: exclusively for research purposes.
Medchemexpress LLC Thalidomide-5-O-C7-NH2 hydrochloride | 98.1% | 423.89 g/mol | C20H26ClN3O5 | 10 MG
Thalidomide-5-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon ligand supplied as the hydrochloride salt for use in chemical biology and targeted protein degradation research. It is designed to be connected to target ligands via a linker to build PROTACs and other CRBN-recruiting constructs, and includes storage recommendations to preserve compound integrity.
- Facilitates cereblon (CRBN) recruitment for targeted degradation studies.
- Hydrochloride salt form for improved handling and stability.
- Compatible with linker conjugation to form PROTAC molecules.
- Provided with documented molecular and storage data to support experimental planning.
- Suitable for research applications requiring characterized E3 ligase ligands.
eMolecules Ambeed / Azetidin-3-one hydrochloride / 250mg / 534082891 / A196857 / / 17557-84-5 / MFCD01861742 / 107.540 / C3H6ClNO
Ambeed / Azetidin-3-one hydrochloride / 250mg / 534082891 / A196857 / / 17557-84-5 / MFCD01861742 / 107.540 / C3H6ClNO