Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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5,881 – 5,895 of 178,527 results

5,881

Medchemexpress LLC Ipragliflozin | 761423-87-4 | 99.7% | 404.45 | 100 MG

Ipragliflozin is an orally active and selective SGLT2 inhibitor that functions as an antidiabetic agent. It has been shown to exhibit potent inhibitory activity against human, rat, and mouse SGLT2, and is intended for research purposes only.

Selective SGLT2 inhibitor
Demonstrates antihyperglycemic effects
Suppresses the growth of MCF-7 human breast cancer cell lines in vitro
Inhibits DNA synthesis in MCF-7 cells in vitro
Reduces HbA1c and blood glucose levels in vivo
Increases pancreatic insulin content in vivo
Increases urinary glucose excretion in vivo

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5,882

Medchemexpress LLC P2Y2R/GPR17 antagonist 1 | 2395016-49-4 | 98.1% | 432.83 | 100 MG

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual antagonist for P2Y2R and GPR17, with IC50 values of 3.17 μM and 1.67 μM, respectively. This compound demonstrates excellent metabolic stability in human liver microsomes.

Dual antagonist for P2Y2R and GPR17.
High metabolic stability in human liver microsomes.

Pricing & Availability

5,883

Medchemexpress LLC Izuforant (JW1601) | 1429374-83-3 | 98.9% | 334.17 | 5 MG

Izuforant (JW1601) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R. It also shows binding affinity to the human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. This compound exhibits strong anti-pruritic and anti-inflammatory efficacies and is suitable for research applications.

Orally active histamine H4 receptor antagonist
Binds to human serotonin 3 receptor
Exhibits strong anti-pruritic and anti-inflammatory efficacies
Shows metabolic stability in mouse and human
Decreases histamine- and substance P-induced itching
Inhibits oxazolone-induced atopic dermatitis

Pricing & Availability

5,884

Medchemexpress LLC Odetiglucan | 53238-80-5 | 16 kDa | 100 MG

Odetiglucan is a novel β-glucan that functions as a potent immunostimulant and a Dectin-1 (CLEC7A) agonist. It activates innate immune effector cells and triggers a coordinated anti-cancer immune response.

Novel β-glucan compound
Potent immunostimulant
Dectin-1 (CLEC7A) agonist
Activates innate immune effector cells
Triggers a coordinated anti-cancer immune response

Pricing & Availability

5,885

Medchemexpress LLC Semagacestat (LY450139) | 425386-60-3 | MFCD09970409 | 361.44 g·mol-1 | C19H27N3O4 | 1 ML

Semagacestat is a small-molecule γ-secretase inhibitor supplied as a 10 mM solution in DMSO for in vitro research. It is used to study amyloid-β production and γ-secretase-related pathways in neuroscience and Alzheimer's disease research, and is characterized by published molecular and chemical identifiers for traceability.

Inhibits γ-secretase activity and reduces amyloid-β peptide production.
Provided as a ready-to-use 10 mM solution in DMSO for reproducible dosing.
Documented molecular formula and weight for analytical confirmation.
Suitable for in vitro and biochemical assays investigating secretase pathways.
Available in solid form for custom formulations if required.

Pricing & Availability

5,886

Medchemexpress LLC CJJ300 | 1807631-83-9 | 99.4% | 435.60 | 100 MG

CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 μM. It inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex. It also disturbs protein-protein interactions, prevents TGF-β receptor dimerization, and suppresses the expression of markers of epithelial-mesenchymal transition (EMT) without cytotoxicity. In human A549 lung epithelial cells, it attenuated the increase of P-Smad2/Smad3, P-Erk1/2, and P-Akt induced by TGF-β. It also down-regulated the expression of EMT-associated proteins, including fibronectin, α-SMA, and MMP-2.

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5,887

Medchemexpress LLC Pumecitinib | 2401057-12-1 | 99.8% | 400.46 | 5 MG

Pumecitinib is a Janus kinase (JAK) inhibitor with anti-inflammatory activity, intended for research use only.

Janus kinase (JAK) inhibitor
Exhibits anti-inflammatory activity
Chemical formula: C17H20N8O2S
Appears as a white to off-white solid
Soluble in DMSO with ultrasonic and warming
Also soluble in 10% DMSO and 90% corn oil for in vivo studies

Pricing & Availability

5,888

Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 25 MG

HS-276 is an orally active, potent, and highly selective TAK1 inhibitor with a Ki of 2.5 nM. It significantly inhibits TAK1 and other kinases including CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1. This compound is useful for research related to rheumatoid arthritis (RA) by reducing the expression of TNF, IL-6, and IL-1β in a dose-dependent manner.

Potent and highly selective TAK1 inhibitor
Reduces inflammation, pannus formation, cartilage damage, bone resorption, and periosteal bone formation in inflammatory arthritis models
Exhibits excellent oral bioavailability in mice

Pricing & Availability

5,889

Medchemexpress LLC ML-210 1g

ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM ML-210 binds the GPX4 selenocysteine residue ML-210 has anti-cancer activity1]2]

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5,890

Medchemexpress LLC Rugonersen | 2591587-57-2 | 98.5% | 6530.30 | 5 MG

Rugonersen is a locked-nucleic acid (LNA)-modified antisense oligonucleotide (ASO) that reduces ubiquitin-protein ligase E3A (UBE3A) silencing. It is used in research for Angelman syndrome (AS), a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A.

Reduces ubiquitin-protein ligase E3A (UBE3A) silencing.
Utilized in Angelman syndrome (AS) research.
Features 98.5% purity.
Demonstrates in vitro nanomolar potency against UBE3A-ATS, UBE3A mRNA, and UBE3A protein upregulation.
Produces robust, long-lasting paternal reactivation of UBE3A mRNA/protein in cynomolgus monkeys.
Well-tolerated in monkey studies.
Available for research use only.

Pricing & Availability

5,891

Medchemexpress LLC 1-O-hexyl-2,3,5-trimethylhydroquinone | 148081-72-5 | 99.9% | 236.35 g/mol | C15H24O2 | 5 MG

HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a lipophilic phenolic antioxidant used in research to scavenge reactive oxygen species and study oxidative-stress related pathways. The compound is documented with CAS 148081-72-5, molecular weight 236.35 g/mol, and is supplied at 99.89% purity.

Lipophilic phenolic antioxidant that scavenges reactive oxygen species.
High purity, 99.89%, for reliable experimental results.
Suitable for in vitro and preclinical oxidative stress studies.
Small-quantity vials convenient for screening and dose-response work.
Documented quality and handling information available via COA and SDS.

Pricing & Availability

5,892

Medchemexpress LLC Vimentin-IN-1 | 2319587-80-7 | C19H18Cl2N4O | 1 ML

Vimentin-IN-1 is a derivative of FiVe1, functioning as an orally active and selective anticancer agent. It targets and binds to the type III intermediate filament protein vimentin (VIM), leading to hyperphosphorylation of Ser56. This action results in the selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Compared to FiVe1, Vimentin-IN-1 exhibits improved oral bioavailability and pharmacokinetic profiles.

Orally active and selective anticancer agent
Targets type III intermediate filament protein vimentin (VIM)
Induces hyperphosphorylation of Ser56
Leads to selective disruption of mitosis and multinucleation in cancer cells
Shows improved oral bioavailability and pharmacokinetic profiles
Inhibits HT-1080 fibrosarcoma with an IC50 value of 44 nM
Induces phosphorylation of VIM at Ser56

Pricing & Availability

5,893

Medchemexpress LLC Moniro-1 | 1909225-94-0 | 99.2% | 458.91 | 5 MG

MONIRO-1 is a T-type and N-type calcium channel blocker suitable for research into pain and epilepsy. It inhibits Ca2+ responses elicited by KCl-mediated depolarization with an IC50 of 124 μM. The compound is more potent against T-type calcium channels (Cav3.1, Cav3.2, and Cav3.3) than N-type (Cav2.2) and L-type channels.

T-type and N-type calcium channel blocker
Exhibits IC50 values of 34, 3.3, 1.7, and 7.2 μM against hCav2.2, hCav3.1, hCav3.2, and hCav3.3
Shows low activity against L-type calcium channels
Can be utilized for research into pain and epilepsy
Inhibits Ca2+ responses elicited by KCl-mediated depolarization (IC50 of 124 μM)
5-100 times more potent against T-type calcium channels than N-type and L-type channels
No inhibition of P/Q (Cav2.1) or R-type currents (Cav2.3) observed at concentrations up to 100 μM
Appears as a white to off-white solid

Pricing & Availability

5,894

Medchemexpress LLC 1-Azakenpaullone | 676596-65-9 | >99.6% | C15H10BrN3O | 25 MG

1-Azakenpaullone (1-Akp) is a highly selective, ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β) with an IC50 of 18 nM. For research use only, it stimulates proliferation in irradiated zebrafish lateral line neuromasts and induces osteoblastic differentiation and mineralization of human mesenchymal stem cells (MSCs) via Wnt signaling. In vivo, it reverses ketamine-induced locomotor hyperactivity in male NMRI mice.

Highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β)
Exhibits an IC50 value of 18 nM
Stimulates proliferation in irradiated zebrafish lateral line neuromasts
Induces osteoblastic differentiation and mineralization of human mesenchymal stem cells (MSCs)
Activates Wnt signaling
Reduces S6K1 phosphorylation in HCC1806 cells
Reverses ketamine-induced locomotor hyperactivity and behavioral aberrations in male NMRI mice

Pricing & Availability

5,895

Medchemexpress LLC Rotigotine hydrochloride | 125572-93-2 | MFCD00906149 | 99.5% | C19H26ClNOS | 5 MG

Rotigotine hydrochloride (N-0923 hydrochloride) is a dopamine receptor full agonist, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Intended for research use only, this solid, white to off-white compound has a molecular weight of 351.93 and is soluble in DMSO and H2O.

Full agonist of the dopamine receptor.
Partial agonist of the 5-HT1A receptor.
Antagonist of the α2B-adrenergic receptor.
Solid, white to off-white appearance.
Soluble in DMSO (≥ 50 mg/mL) and H2O (4.76 mg/mL).
Ki of 0.71 nM for the dopamine D3 receptor.
Ki of 4-15 nM for the D2, D5, and D4 receptors.
Ki of 83 nM for the dopamine D1 receptor.

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Pyridines and derivatives

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Medchemexpress LLC Ipragliflozin | 761423-87-4 | 99.7% | 404.45 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC P2Y2R/GPR17 antagonist 1 | 2395016-49-4 | 98.1% | 432.83 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Izuforant (JW1601) | 1429374-83-3 | 98.9% | 334.17 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Odetiglucan | 53238-80-5 | 16 kDa | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Semagacestat (LY450139) | 425386-60-3 | MFCD09970409 | 361.44 g·mol-1 | C19H27N3O4 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CJJ300 | 1807631-83-9 | 99.4% | 435.60 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pumecitinib | 2401057-12-1 | 99.8% | 400.46 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC ML-210 1g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Rugonersen | 2591587-57-2 | 98.5% | 6530.30 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-O-hexyl-2,3,5-trimethylhydroquinone | 148081-72-5 | 99.9% | 236.35 g/mol | C15H24O2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Vimentin-IN-1 | 2319587-80-7 | C19H18Cl2N4O | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Moniro-1 | 1909225-94-0 | 99.2% | 458.91 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-Azakenpaullone | 676596-65-9 | >99.6% | C15H10BrN3O | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Rotigotine hydrochloride | 125572-93-2 | MFCD00906149 | 99.5% | C19H26ClNOS | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More