Pyridines and derivatives
Medchemexpress LLC Penao | 1192411-43-0 | MFCD25976838 | 96.7% | 390.29 | C13H19AsN2O5S | 10 MG
PENAO is a small-molecule arsenical mitochondrial toxin that inactivates tumor cell mitochondria by targeting the inner-membrane adenine nucleotide transferase (ANT). It is supplied as a research reagent in milligram quantities for in vitro studies; the compound contains arsenic and must be handled per the safety data sheet (SDS).
- Potent tumor cell mitochondrial toxin that disrupts mitochondrial function.
- Mechanism: targets inner-membrane adenine nucleotide transferase (ANT).
- Available in small-milligram quantities suitable for laboratory research.
- Purity approximately 96.7% as provided by the manufacturer.
- Contains arsenic; follow the safety data sheet (SDS) for handling and disposal.
- For research use only; not for human or clinical use.
Medchemexpress LLC Glutathione arsenoxide TFA | 00-00-0 | 99.9% | C20H26AsF3N4O11S | 10MG
Glutathione arsenoxide TFA is an arsenic-containing derivative of glutathione used as a research reagent and tumour metabolism inhibitor. It modulates mitochondrial function and is employed in cellular studies probing mitochondrial targets and cancer cell metabolism. Supplied as the trifluoroacetate (TFA) salt in small milligram quantities, it is intended for laboratory research use only.
- Arsenic-containing glutathione derivative that modulates mitochondrial function.
- Acts as a tumour metabolism inhibitor; used in cancer research applications.
- Suitable for cellular and in vitro biochemical assays.
- High purity (≈99.9%).
- Available in small milligram quantities for exploratory studies.
Medchemexpress LLC 2,3-Dimercapto-1-propanol | 59-52-9 | 98.0% | 500 MG
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent that also exhibits anti-HIV activity. It can be utilized for research into poisoning caused by arsenic, mercury, gold, lead, antimony, and other toxic metals.
- Anti-heavy metal-poisoning agent
- Exhibits anti-HIV activity
- Useful for studying poisoning from arsenic, mercury, gold, lead, and antimony
- Significantly protected PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner in vitro.
- Decreased mercury contents in the liver and kidney in Wistar rats in vivo.
Medchemexpress LLC FlAsH-EDT2 | 212118-77-9 | MFCD27977924 | 99.0% | C24H18As2O5S4 | 10MG
FlAsH-EDT2 is a fluorescein-based biarsenical probe that selectively binds tetracysteine (CCXXCC) motifs in proteins. It is membrane-permeant and largely nonfluorescent until it binds the target sequence, whereupon it produces strong green fluorescence suitable for live-cell imaging and in vitro biochemical assays. The compound contains arsenical groups; follow manufacturer safety and handling guidance.
Medchemexpress LLC Dimercaprol | 59-52-9 | 98.0% | 1 G
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent that also exhibits anti-HIV activity. It is used for research on poisoning by arsenic, mercury, gold, lead, antimony, and other toxic metals.
- Anti-heavy metal-poisoning agent
- Exhibits anti-HIV activity
- Can be used for the study of arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning
- Can significantly protect PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner
- Decreases mercury contents in liver and kidney in Wistar rats exposed to HgCl2
- Appearance: Liquid (Density: 1.239 g/cm³)
- Color: Colorless to off-white
Medchemexpress LLC Darinaparsin | 69819-86-9 | ≥98.0% | 411.31 | 5 MG
Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent that induces apoptosis in cancer cells and exhibits anticancer effects.
- Cytotoxic to prostate cancer cell lines and fresh prostate cancer cells at low micromolar concentrations.
- Inhibits tumor-initiating cells (TIC) subpopulations.
- Inhibits growth of the castrate-resistant Du145 prostate tumor propagated as a xenograft in mice.
- Inhibits the tumor-initiating potential of prostate cancer cells.
Medchemexpress LLC Darinaparsin (S-dimethylarsino-glutathione) | 69819-86-9 | MFCD17215931 | ≥98.0% | 411.31 g/mol | C12H22AsN3O6S | 10 MG
Darinaparsin is an organic arsenical research compound (S-dimethylarsino-glutathione) with mitochondrial-targeted activity that induces apoptosis in cancer cells. It is used in preclinical and translational studies to evaluate anticancer mechanisms and to explore combination therapies.
- Mitochondrial-targeted mechanism of action.
- Induces apoptosis in multiple cancer cell types.
- Suitable for preclinical and translational anticancer research.
- High purity appropriate for research applications.
- Molecular formula C12H22AsN3O6S and molecular weight 411.31 g/mol.
- CAS number 69819-86-9 for unambiguous identification.
Medchemexpress LLC Melarsoprol | 494-79-1 | 98.0% | 1 MG
Melarsoprol is a trivalent organic arsenical research reagent used primarily as an antitrypanosomal agent; it can cross the blood-brain barrier and induces apoptosis in certain leukemic cells. Supplied as a powdered research-grade compound for laboratory use.
- Antitrypanosomal activity; crosses the blood-brain barrier.
- Research-grade powder, purity 98.0%.
- Molecular formula C12H15AsN6OS2; molecular weight 398.34 g/mol.
- Physical form: powder; recommended storage: -20°C (powder, stable 3 years) or 4°C (powder, stable 2 years).
- Intended for research use only.
![Medchemexpress LLC Glycine, L-y-glutamyl-S-[2-[[4-(dihydroxyarsino)phenyl]amino]-2-oxoethyl]-L-cysteinyl- (TFA) | 00-00-0 | 99.9% | 662.42 g/mol | C20H26AsF3N4O11S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262221.png-250.jpg)
Medchemexpress LLC Glycine, L-y-glutamyl-S-[2-[[4-(dihydroxyarsino)phenyl]amino]-2-oxoethyl]-L-cysteinyl- (TFA) | 00-00-0 | 99.9% | 662.42 g/mol | C20H26AsF3N4O11S | 5 MG
Glutathione arsenoxide TFA is an arsenic-containing derivative of glutathione provided for research use. It acts as a tumour metabolism inhibitor that targets the mitochondrial adenine nucleotide translocator (ANT) and is used to study mitochondrial function and to identify certain cell-surface proteins.
- Potential anticancer research reagent targeting mitochondrial ANT.
- Useful for identifying cell-surface proteins such as protein disulfide isomerase.
- Supplied as a white to off-white solid in trifluoroacetic acid salt form.
- High purity (≈99.9%) suitable for analytical and biological studies.
- Documentation available: datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Hydroxy-PP-Me | 833481-77-9 | 99.9% | 282.34 g/mol | C16H18N4O | 10 MG
Hydroxy-PP-Me is a selective small-molecule inhibitor of carbonyl reductase 1 (CBR1) used in cancer research. It inhibits serum starvation-induced apoptosis and can enhance the cytotoxic effects of daunorubicin and arsenic trioxide. Supplied as a high-purity analytical reagent, it is commonly provided as a 10 mg unit.
- High purity: 99.92%.
- Molecular formula C16H18N4O; molecular weight 282.34 g/mol.
- Identified CAS number 833481-77-9.
- Reported CBR1 IC50 ≈ 759 nM.
- Solubility: soluble in DMSO; available as 10 mM solutions in DMSO.
- For research use only; not for human or diagnostic use.
Sigma Aldrich Fine Chemicals Biosciences Phosphatase Alkaline from
The enzyme is a glycoprotein containing approximately 12% carbohydrate (6% hexoses and 6% other neutral sugars). Each molecule of alkaline phosphatase contains four zinc atoms and four disulfide bridges. Maximal activity with alkaline phosphatase is achieved in the presence of magnesium. It catalyzes the hydrolysis of phosphate monoesters such as p-nitrophenyl phosphate phenyl phosphate phenolphthalein phosphate glycerol phosphate -glycerol phosphate 2-phosphorylglycerate triosephosphate glucose-6-phosphate glucose 1-phosphate fructose 1-phosphate fructose 6-phosphate adenosine 5-phosphate adenosine 3-phosphate phosphoenolpyruvate and -nicotinamide adenine dinucleotide phosphate. Arsenate cysteine iodine inorganic phosphate pyrophosphate diisopropyl phosphate triphenylphosphate diisopropyl fluorophosphate and L-phenylalanine are some of the strong inhibitors of alkaline phosphatase.
Sigma Aldrich Fine Chemicals Biosciences Human Fibroblast Like Syno
HFLS-RA provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of rheumatoid arthritis. HFLS-RA have been used in numerous research studies to.nbspStudy signaling pathways implicated in the development of joint inflammation and rheumatoid arthritis (Abe, 2006 Akasaka, 2005 Bai, 2012 Fan, 2013 Furuhashi, 2008 Hashizume, 2008 Matsuyama, 2010 Tsuji, 1999 Yamaguch, 2012a,b Yano, 2001).nbspEvaluate possible contribution of EBV to nonresolving rheumatoid arthritis inflammation through inducing IL-6 production by synoviocytes (Chiu, 2013).nbspEvaluate the anti-inflammatory and antirheumatic activity of various compounds, such as celastrol (Venkatesha, 2011 Xu, 2013), triptolide (Kong, 2013 Lin, 2013), arsenic trioxide (Mei, 2011), Wen Luo Yin (Liu, 2013), bucillamine (Tsuji, 2007), therapeutic lyposomes (Harigai, 2007 Ichihara, 2011 Matsumoto, 2013 Negishi, 2011), anti-IL-6R and anti-CD319 antibodies (Suzuki, 2010 Woo, 2013), as well a
Medchemexpress LLC ZCL278 | 587841-73-4 | 98.5% | 584.89 | 50 MG
ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. It can disrupt the Cdc42-ITSN interaction and GTP/GDP binding. ZCL278 shows inhibitory effects on various enveloped viruses but is ineffective against non-enveloped viruses. It is also used in studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC).
- Impedes wound healing in PC-3 cells
- Inhibits Cdc42 activity in PC-3 cells
- Inhibits mice primary neurons branching and growth cone motility
- Prevents release of Junin virus (JUNV) ribonucleoprotein cores
- Inhibits VSV, LCMV, and DV2 infections
- Improves cytotoxicity of NaAsO2 in rat astrocytes
- Reduces cholesterol levels and reverses collateral resistance in TC cells
- Inhibits JUNV replication in a mouse model
- Reduces cholesterol enrichment and reverses collateral resistance in vivo