Pyrroles
Medchemexpress LLC Bromoenol lactone | 88070-98-8 | MFCD00270871 | ≥98.0% | 317.18 g/mol | C16H13BrO2 | 1 ML
Bromoenol lactone is an irreversible, suicide-type inhibitor of calcium-independent phospholipase A2 (iPLA2β). It is provided as a concentrated solution (commonly 10 mM in DMSO) for biochemical and cell-based research, with a reported IC50 of approximately 7 μM.
- Irreversible inhibitor of calcium-independent phospholipase A2 (iPLA2β).
- Reported IC50 of approximately 7 μM.
- Supplied as a 10 mM solution in DMSO for laboratory use.
- High purity: ≥98.0% (TLC).
- Chemical formula C16H13BrO2, molecular weight 317.18 g/mol.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Atorvastatin epoxy tetrahydrofuran impurity | 873950-19-7 | 449.47 | 50 MG
Atorvastatin epoxy tetrahydrofuran impurity is an impurity isolated from the oxidative degradation products of atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor that effectively decreases blood lipids. This product is for research use only and not sold to patients.
- Isolated from oxidative degradation products of atorvastatin.
- Atorvastatin is an orally active HMG-CoA reductase inhibitor.
- Effectively decreases blood lipids.
- Reduces apoptosis of myocardial cells by down-regulating GRP78, caspase-12, and CHOP expression after myocardial infarction.
- Involved in activation of endoplasmic reticulum (ER) stress in response to heart failure and angiotensin II (Ang II) stimulation.
Medchemexpress LLC Pravastatin lactone | 85956-22-5 | 99.2% | 5 MG
Pravastatin lactone is the delta-lactone metabolite of pravastatin and a potent inhibitor of HMG-CoA reductase. It is used as a research reagent to study statin metabolism and cholesterol biosynthesis in biochemical and pharmacological assays.
- Potent HMG-CoA reductase inhibitor used in cholesterol synthesis studies.
- High purity suitable for analytical and biochemical applications.
- Available in small milligram quantities for assay development and metabolism studies.
- Molecular formula C23H34O6 and molecular weight 406.51 g/mol aid identification and dosing.
- Provided as a neat solid for laboratory research use.
Medchemexpress LLC Pizotifen malate | 5189-11-7 | 99.0% | C23H27NO5S | 100 MG
Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist with high affinity for the 5-HT1C binding site. It acts as an antidepressant 5-HT2A receptor antagonist, capable of inhibiting serotonin-enhanced ADP-induced platelet aggregation. This product is intended for research use only and is not sold to patients.
- Potent 5-HT2 receptor antagonist
- High affinity for the 5-HT1C binding site
- Antidepressant 5-HT2A receptor antagonist
- Inhibits serotonin-enhanced ADP-induced platelet aggregation
- Intended for research use only
Medchemexpress LLC Compound 48/80 trihydrochloride | 848035-21-2 | 1 ML
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. It acts as a histamine releaser and a mast cell degranulator. This compound inhibits phosphatidylinositol-specific phospholipase C activity from human platelets, with IC50 values of 2.1 μg/ml (supernatant) and 5.0 μg/ml (particulate fraction). It also inhibits the aggregation of human platelets induced by ADP and PAF-acether.
- Acts as a histamine releaser and mast cell degranulator.
- Inhibits phosphatidylinositol-specific phospholipase C activity.
- Inhibits human platelet aggregation induced by ADP and PAF-acether.
- Increases serum serotonin, histamine, and corticosterone levels in vivo.
- Causes oxidative stress in rat adrenal glands through mast cell degranulation.
Cayman Chemical 4-hydroxy Atorvastatin calci
A metabolite of atorvastatin; formed by metabolism of atorvastatin by CYP3A4
Medchemexpress LLC Atorvastatin ethyl ester | 1146977-93-6 | MFCD28143549 | 98.2% | 586.69 g/mol | C35H39FN2O5 | 5 MG
Atorvastatin ethyl ester is a research chemical derivative of atorvastatin reported to strongly inhibit 9-cis-retinoic acid (9-cis-RA)-induced Gal4 reporter activity. It is intended for preclinical research use and is characterized by CAS 1146977-93-6, molecular formula C35H39FN2O5, and molecular weight 586.69 g/mol.
- Reported inhibitor of 9-cis-RA-induced Gal4 reporter activity.
- Intended for research use only, not for human consumption.
- High purity (98.2%).
- Characterized by CAS 1146977-93-6 and formula C35H39FN2O5.
- Available in small pack sizes suitable for assay development, including five mg packs.
Medchemexpress LLC Atorvastatin lactone | 125995-03-1 | MFCD00899262 | 96.7% | 540.62 g·mol-1 | C33H33FN2O4 | 5 MG
Atorvastatin lactone is the lactone (prodrug) form of atorvastatin, acting as an HMG-CoA reductase inhibitor used in research on cholesterol biosynthesis, statin metabolism, and enzymatic assays. Supplied as a purified solid, it is typically prepared as a DMSO stock for in vitro and analytical applications.
- Prodrug/lactone form of atorvastatin for metabolic and pharmacology studies.
- High purity suitable for analytical and biochemical assays.
- Powder form; soluble in DMSO for stock preparations.
- Molecular weight approximately 540.62 g·mol-1.
- Used as an HMG-CoA reductase inhibitor in research applications.
Medchemexpress LLC 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-2-methoxybenzamide;2-hydroxybutanedioic acid | 57645-91-7 | MFCD01743960 | 99.4% | 507.96 | C24H30ClN3O7 | 10 MG
Clebopride malate is the malate salt of clebopride, an orally active dopamine D2 receptor antagonist supplied as a research-grade analytical standard for laboratory pharmacology and analytical studies. It is provided as a high-purity solid intended for controlled experimental use and should be stored sealed and away from moisture; solutions may be frozen for extended storage.
- Malate salt form of clebopride.
- Orally active dopamine D2 receptor antagonist.
- High purity suitable for analytical applications.
- Supplied in a small research-grade pack for laboratory use.
- Stable when stored sealed and away from moisture; follow refrigerated or frozen conditions for solutions.
Medchemexpress LLC Atorvastatin hemicalcium salt | 134523-03-8 | 99.9% | 577.67 | 200 MG
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with blood-brain barrier permeability. It has the ability to effectively decrease blood lipids. This compound inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
- Orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
- Possesses blood-brain barrier permeability.
- Effectively decreases blood lipids.
- Inhibits human SV-SMC proliferation and invasion.
Medchemexpress LLC HY-112898 10mg Medchemexpress, DC1SMe CAS:501666-85-9 Purity:>98%
Medchemexpress, HY-112898 10mg DC1SMe CAS:501666-85-9 DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Almotriptan Malate 181183-52-8 10mM (in 1mL DMSO)
Almotriptan Malate (CAS 181183-52-8) is a small molecule belonging to the triptan class acting as a selective agonist at 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptors By stimulating these receptors Almotriptan modulates cranial vasoconstriction and inhibits the release of pro-inflammatory neuropeptides biologically counteracting migraine pathophysiology In research applications Almotriptan Malate is utilized to investigate serotonergic signaling pathways migraine mechanisms and the pharmacodynamics of 5-HT1B/1D receptor modulation in neurological models
Medchemexpress LLC Sunitinib impurity 28 | 1186651-51-3 | 98.5% | 299.31 | 50 MG
Sunitinib impurity 28 is a well-characterized impurity of Sunitinib, identified as an important reference standard. It is provided with high purity and a defined molecular weight, making it suitable for research and analytical applications.
- Purity: 98.5%
- Molecular weight: 299.31
- Formula: C16H14FN3O2
- CAS number: 1186651-51-3
- Appearance: Solid
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
Apexbio Technology LLC Bromoenol lactone 88070-98-8 50mg
Bromoenol lactone (CAS 88070-98-8) is an irreversible inhibitor of cytosolic calcium-independent phospholipase A2 (iPLA2) an enzyme involved in the regulation of arachidonic acid release and lysophospholipid production iPLA2 activity is associated with phospholipid remodeling and the generation of signaling molecules that modulate processes such as eicosanoid synthesis insulin secretion apoptosis and cellular proliferation In cellular assays bromoenol lactone induces apoptosis in various cell lines and promotes proteolysis of procaspase-9 and procaspase-3 It also inhibits phosphatidic acid phosphohydrolase activity and disrupts triacylglycerol biosynthesis in macrophage models Bromoenol lactone is widely utilized in studies investigating lipid signaling cell death mechanisms and metabolic pathways
Medchemexpress LLC Atorvastatin epoxy tetrahydrofuran impurity | 873950-19-7 | MFCD31700699 | 96.0% | C26H24FNO5 | 10MG
Atorvastatin epoxy tetrahydrofuran impurity is an oxidative degradation product of atorvastatin provided as an analytical reference standard for research use. Supplied in milligram quantities, it supports impurity profiling, method development, and stability testing. Users should consult the lot-specific Certificate of Analysis for purity and storage conditions.
- Used as an impurity reference for analytical method development.
- Suitable for stability studies and degradation profiling.
- Provided in small, laboratory-scale quantities for research use.
- Chemical formula C26H24FNO5 and CAS 873950-19-7 for unambiguous identification.
- Lot-specific purity and storage conditions available in the Certificate of Analysis.