Quinolines and derivatives
eMolecules 5622-36-6 | Methyl 2-(quinolin-6-yl)acetate | Synthonix | MFCD04038669 | 201.225 | C12H11NO2 | 95.000 | COC(=O)Cc1ccc2ncccc2c1 | 250mg | 649427514
Methyl 2-(quinolin-6-yl)acetate | Synthonix | 5622-36-6 | MFCD04038669 | 201.225 | C12H11NO2 | 95.000 | COC(=O)Cc1ccc2ncccc2c1 | 250mg | 649427514
Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | MFCD30343546 | 97.0% | 324.41 | 250 MG
Amino-PEG6-amine is a PROTAC linker, based on a PEG (polyethylene glycol) chain with 6 units, which can be utilized in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based (6 units) PROTAC linker
- Can be used in the synthesis of PROTACs
eMolecules 859924-25-7 | 6-aminoquinoline-4-carboxylic acid | MFCD09837175 | 1g
Pharmablock | 6-aminoquinoline-4-carboxylic acid | 1g | 551240925 | PBKR2085 | 859924-25-7 | MFCD09837175 | 188.186 | C10H8N2O2
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Medchemexpress LLC 5-Hydroxyquinoline | 578-67-6 | 98.4% | 145.16 | 10 G
5-Hydroxyquinoline is an organic compound commonly used in certain chemical reactions and biological research. It can be used in the manufacture of dyes, cellulase, oxidants and passivators, etc., and is widely used in the pigment, paint and rubber industries. In addition, the compound is also used as the precursor, intermediate and metal ion complexing agent of certain drugs.
- Is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Medchemexpress LLC VK-II-86 | 955371-84-3 | 93.3% | 420.50 | 500 MG
VK-II-86 is a Carvedilol analogue that lacks antagonist activity at β-adrenoceptors in hypokalaemia. This compound effectively prevents hypokalaemia-induced ventricular arrhythmia through its multi-channel effects, counteracting all hypokalaemia-induced changes in ion channel activity and oxidative stress. For research use only.
- Carvedilol analogue
- Lacks antagonist activity at β-adrenoceptors
- Prevents hypokalaemia-induced ventricular arrhythmia
- Exhibits multi-channel effects
- Counters hypokalaemia-induced changes in ion channel activity
- Counters hypokalaemia-induced oxidative stress
- Markedly reduces non-sustained and sustained ventricular tachyarrhythmias in a hypokalaemic murine whole-heart model
Medchemexpress LLC Sulfo-Cy5 amine | 2183440-44-8 | 98.0% | 740.97 | C38H52N4O7S2 | 10 MG
Sulfo-Cy5 amine is a water-soluble, near-infrared fluorescent dye containing a primary amine for covalent conjugation to electrophilic targets. Sulfonate groups increase aqueous solubility, making the dye suitable for labeling biomolecules in biological buffers and imaging applications.
- Water-soluble cyanine dye suitable for near-infrared imaging.
- Primary amine functional group enables amine-reactive conjugation.
- High purity (98.0%) supports reproducible labeling results.
- Sulfonate groups enhance solubility in aqueous media and biological buffers.
- Available in small milligram pack sizes for research-scale use.
AdipoGen Propidium iodide
Chemical. CAS 25535-16-4. Formula C27H34I2N4. MW 668.39. Synthetic. Propidium iodide is the most common red-fluorescent nuclear stain. It can also be excited using excitation filters appropriate for green-fluorescent dyes.
Sigma Aldrich Fine Chemicals Biosciences PharmalyteR 8 10.5 Cytiv
Pharmalyte(R) carrier ampholytes prepared by the co-polymerization of glycine glycylglycine amines and epichlorohydrin are available in five broad-range and four narrow-range pH intervals. Each interval contains numerous ampholytes with a high buffering capacity per pH unit. Pharmalyte(R) carrier ampholytes form an extremely stable linear pH gradient and exhibit even conductivity across the gel. For precast PhastGel(R) gels for PhastSystem see PhastGel.
AdipoGen Quinine anhydrous
Chemical. CAS 130-95-0. Formula C20H24N2O2. MW 324.42. Synthetic. Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used in photochemistry as a common fluorescence standard. It has been used for imaging of oxygen evolution and oxide formation. Chloride and bromide have been shown to quench fluorescence. Generally it is famous as potassium channel blocker with antipyretic fever-reducing, antimalarial, analgesic painkilling, and anti-inflammatory properties.
AdipoGen Propidium Iodide Solution
Chemical. CAS 25535-16-4. Formula C27H34I2N4. MW 668.39. Synthetic. Most common red-fluorescent nuclear stain. Membrane impermeant and generally excluded from viable cells. It can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques. It binds to DNA and RNA by intercalating between the bases. Suitable for use in fluorescence microscopy, confocal laser scanning microscopy, flow cytometry and fluorometry. Spectral data lambdaex=488-535nm, lambdaem=617nm.
Sigma Aldrich Fine Chemicals Biosciences Ethyl 2 trans 4 cis decadi1KG
Ethyl 2 trans 4 cis decadi1KG
eMolecules 288154-18-7 | tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Combi-Blocks | MFCD04114477 | 243.307 | C11H21N3O3 | 98.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 10g | 517028767
tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Combi-Blocks | 288154-18-7 | MFCD04114477 | 243.307 | C11H21N3O3 | 98.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 10g | 517028767
Apexbio Technology LLC BGJ398(Synonyms: Infigratinib, NVP-BGJ398, BGJ-398, BGJ 398), 200mg, CAS: 872511-34-7.
BGJ398 (CAS 872511-34-7) also known as NVP-BGJ398 is an orally bioavailable small-molecule inhibitor targeting fibroblast growth factor receptors (FGFRs) It selectively inhibits receptor tyrosine kinase activity of FGFR1 FGFR2 FGFR3 and FGFR4 which are critical mediators in signal transduction pathways involved in cell proliferation differentiation and survival In preclinical studies BGJ398 suppresses proliferation and induces apoptosis in FGFR-dependent cancer cells additionally it demonstrates antitumor activity in xenograft tumor models BGJ398 is utilized as a research tool in oncology studies investigating FGFR-driven malignancies
Medchemexpress LLC Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]- | 312636-16-1 | 99.25% | 302.78 | 200 MG
SKI-II is an orally active and synthetic inhibitor of sphingosine kinase (SK) activity. It is intended for research use only and causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. It inhibits cell proliferation and promotes β-catenin degradation.
- Orally active and synthetic inhibitor of sphingosine kinase (SK) activity
- IC50 values: 78 μM for SK1 and 45 μM for SK2
- Causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation
- Inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway
- Promotes the degradation of β-catenin by enhancing Wnt5A
- Shows synergistic effect with DDP in human gastric carcinoma SGC7901/DDP cell line
- Reduces S1P concentrations in plasma in mice with chronic administration
- Reduces tumor growth in mice bearing solid tumor models
Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 10mg, CAS: 104821-25-2.
Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer