Alcohols and polyols
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- (1)
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- (1)
- (1)
- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Ansofaxine hydrochloride | 916918-84-8 | 417.97 | 1 ML
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Ansofaxine hydrochloride (LY03005) is a triple reuptake inhibitor that targets serotonin, dopamine, and norepinephrine. It is intended for research use only.
- Inhibits serotonin reuptake (IC50: 723 nM)
- Inhibits dopamine reuptake (IC50: 491 nM)
- Inhibits norepinephrine reuptake (IC50: 763 nM)
- Purity of 99.44%
- Molecular weight of 417.97
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Zenidolol hydrochloride | 72795-01-8 | 99.7% | 313.86 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Zenidolol hydrochloride (ICI-118551) is a highly selective β2 adrenergic receptor antagonist, demonstrating potent inhibition with Kis of 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors, respectively. It is for research use only.
- Highly selective β2 adrenergic receptor antagonist
- Inhibits cAMP accumulation with an IC50 of 1.7 μM in IMCD cells
- Induces prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO (at 10 μM)
- Has significant effects on beat duration in failing human heart, reducing time-to-peak contraction and time-to-90% relaxation compared with basal contraction
- Negative inotropic effect is not cAMP-related
- Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects
- Reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure when injected into the jugular vein of mice (at 0.2 mg/kg)
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Sultopride hydrochloride (LIN-1418 hydrochloride) | 23694-17-9 | 99.9% | 390.93 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor, suitable for research use only.
- Functions as a selective dopamine D2 receptor antagonist.
- Increases DOPAC and HVA levels in the striatum, nucleus accumbens, and medial prefrontal cortex in rats.
- Demonstrates higher DOPAC and HVA levels in treated rats compared to sulpiride-treated rats in the striatum and nucleus accumbens.
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Medchemexpress LLC Tocainide hydrochloride | 71395-14-7 | 99.5% | 5 MG
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Tocainide hydrochloride is a sodium channel blocker that blocks sodium channels in the pain-producing foci in nerve membranes. It is a primary amine analog of lidocaine and can be used for the treatment of tinnitus.
- Sodium channel blocker.
- Blocks sodium channels in pain-producing foci in nerve membranes.
- Can be used for the treatment of tinnitus.
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Medchemexpress LLC Verapamil hydrochloride | 152-11-4 | 99.98% | C27H39ClN2O4 | 25 MG
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Verapamil hydrochloride is a calcium channel blocker and a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. It also inhibits CYP3A4. This compound is used for research related to high blood pressure, heart arrhythmias, and angina.
- Calcium channel blocker
- Potent first-generation P-glycoprotein (P-gp) inhibitor
- Inhibits CYP3A4
- Used in research for high blood pressure and heart arrhythmias
- Modulates atrioventricular nodal response in atrial fibrillation
- Decreases incidence of ventricular arrhythmias
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Medchemexpress LLC Pociredir (hydrochloride) | 2490676-19-0 | 99.9% | 439.87 | 25 MG
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Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). It can induce HbF protein expression in cell and murine models and is used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia.
- Inhibits PRC2 via binding to EED
- Induces robust HbF protein expression in cell and murine models
- Used for research of select hemoglobinopathies
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Medchemexpress LLC Asenapine hydrochloride | 1412458-61-7 | 99.95% | 322.23 | 5 MG
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Asenapine (Org 5222) hydrochloride is an atypical antipsychotic. It acts as an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4), and histamine receptors (pKi: 8.2-9.0). This product can be utilized in research pertaining to schizophrenia and bipolar disorder.
- Antagonist of various serotonin receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5-HT7).
- Antagonist of adrenergic receptors (α2A, α2B, α2C).
- Antagonist of dopamine receptors (D2, D3, D4).
- Antagonist of histamine receptors (H1).
- Investigated for its use in schizophrenia and bipolar disorder research.
- Shown to reduce anxiety-related behaviors in rat conditioned fear stress models.
- Exhibits anxiolytic-like effects in mice.
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Medchemexpress LLC AMXI-5001 hydrochloride | 2170491-77-5 | 98.1% | C25H21ClFN5O3 | 25 MG
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AMXI-5001 hydrochloride is a potent, orally active, dual PARP1/2 and microtubule polymerization inhibitor. It shows selective antitumor cytotoxicity against various human cancer cells with significantly lower IC50s compared to existing clinical PARP1/2 inhibitors. This compound has been observed to induce complete regression of established tumors, even exceedingly large ones.
- Potent, orally active, dual PARP1/2 and microtubule polymerization inhibitor
- Shows selective antitumor cytotoxicity against various human cancer cells
- Significantly lower IC50s compared to existing clinical PARP1/2 inhibitors
- Induces complete regression of established tumors, even exceedingly large ones
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Medchemexpress LLC Imidapril hydrochloride | 89396-94-1 | 99.9% | 25 MG
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Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. It suppresses the conversion of angiotensin I to angiotensin II, leading to a reduction in total peripheral resistance and systemic blood pressure.
- Orally active ACE and MMP-9 inhibitor
- Reduces total peripheral resistance and systemic blood pressure
- Used for hypertension, type 1 diabetic, nephropathy, and chronic heart failure research
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Medchemexpress LLC Epz020411 (hydrochloride) | 2070015-25-5 | 98.15% | 479.06 | 10 MG
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EPZ020411 hydrochloride is a selective inhibitor of PRMT6 with an IC50 of 10 nM. It demonstrates more than 10-fold selectivity for PRMT6 over PRMT1 and PRMT8. This compound can be utilized for cancer research.
- Selective inhibitor of PRMT6
- IC50 of 10 nM for PRMT6
- Exhibits greater than 10-fold selectivity for PRMT6 over PRMT1 and PRMT8
- Suitable for cancer research
- Off-white to light yellow solid appearance
- Soluble in DMSO, 0.1 M HCl, and water
- Stock solutions stable for 1 year at -80°C or 6 months at -20°C (under nitrogen)
- Shows synergistic anti-proliferative effects on HCT116 and SW620 cells
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Medchemexpress LLC Nordoxepin hydrochloride | 2887-91-4 | 99.9% | 301.81 g/mol | C18H20ClNO | 50 MG
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Nordoxepin hydrochloride is the major active metabolite of the tricyclic antidepressant doxepin, supplied as a research-grade reference standard for analytical and pharmacological studies.
- Molecular formula: C18H20ClNO.
- Molecular weight: 301.81 g/mol.
- CAS number: 2887-91-4.
- Purity: 99.9%.
- Appearance: white to off-white solid.
- Recommended storage: 4°C sealed; in solvent -80°C up to 6 months, -20°C up to 1 month.
- Supplied amount: 50 mg.
- Intended use: for research and analytical applications.
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Medchemexpress LLC Embramine hydrochloride | 13977-28-1 | 384.74 | 50 MG
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Embramine hydrochloride is a monoethanolamine used as an antihistamine and anticholinergic.
- Antihistamine
- Anticholinergic
- For research use only
- Related to Histamine receptor research
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Medchemexpress LLC VU0453379 hydrochloride | 98.0% | 471.03 | 25 MG
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VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.
- Highly selective
- CNS penetrant
- Positive allosteric modulator (PAM) of GLP-1R
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Medchemexpress LLC Amxi-5001 hydrochloride | 98.05% | C25H21ClFN5O3 | 50 MG
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AMXI-5001 hydrochloride is a potent, orally active compound that acts as a dual inhibitor of parp1/2 and microtubule polymerization. It demonstrates selective antitumor cytotoxicity across various human cancer cells, with significantly lower IC50s compared to existing clinical PARP1/2 inhibitors. AMXI-5001 hydrochloride has been shown to induce complete regression of established tumors, including large ones.
- Potent, orally active, dual parp1/2 and microtubule polymerization inhibitor.
- Exhibits selective antitumor cytotoxicity in a wide range of human cancer cells.
- Shows much lower IC50s than current clinical PARP1/2 inhibitors.
- Capable of inducing complete regression of established tumors, including exceedingly large tumors.
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Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | 99.9% | 430.32 | 100 MG
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Befiradol hydrochloride | 2436760-81-3 | 99.9% | 430.32 | 100 MG
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