Alcohols and polyols
Medchemexpress LLC Azido-PEG10-alcohol | 877239-09-3 | C20H41N3O10 | 1 G
Azido-PEG10-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent containing an azide group. This reagent is capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent with an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol | 86770-69-6 | MFCD22056309 | 98.0% | 307.34 g/mol | C12H25N3O6 | 1 G
Azido-PEG6-alcohol is a polyethylene glycol (PEG) linker bearing a terminal azide and a primary hydroxyl group, used as a click-chemistry reagent and linker in bioconjugation and PROTAC/ADC synthesis.
- Water-soluble PEG6 linker with azide and hydroxyl functional groups.
- Useful for copper-free and copper-catalyzed click reactions.
- Commonly used as a spacer/linker in antibody-drug conjugates and PROTACs.
- Molecular weight approximately 307.34 g/mol and formula C12H25N3O6.
- Available in small-scale laboratory quantities (e.g., 1 G) and typically supplied with high purity.
Medchemexpress LLC EPZ011989 hydrochloride | 2095432-26-9 | 99.4% | 642.27 | 50 MG
EPZ011989 hydrochloride is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor, with a Ki value of <3 nM. It demonstrates anti-tumor activity and is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and orally active Zeste Homolog 2 (EZH2) inhibitor
- Shows anti-tumor activity
- Click chemistry reagent containing an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Azido-PEG4-alcohol | 86770-67-4 | 98.88% | 219.24 | 1 G
This is a PEG-based linker used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that have Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based linker
- Click chemistry reagent
- Contains an Azide group
- Can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC EPZ011989 hydrochloride | 2095432-26-9 | 99.4% | 642.27 | 5 MG
EPZ011989 hydrochloride is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor, with a Ki value of <3 nM. It shows anti-tumor activity and is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and orally active Zeste Homolog 2 (EZH2) inhibitor
- Ki value of <3 nM
- Shows anti-tumor activity
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Azide-PEG12-alcohol | 1821464-55-4 | 99.8% | C24H49N3O12 | 250 MG
Azide-PEG12-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring an Azide group. It can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent with an azide group
- Engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Used in PROTAC synthesis
![Medchemexpress LLC Ethanol, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 86770-67-4 | 98.88% | 219.24 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402648-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanol, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 86770-67-4 | 98.88% | 219.24 | 250 MG
Azido-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Peg-based PROTAC linker
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Appearance: liquid
- Color: colorless to light yellow
Medchemexpress LLC Azido-PEG2-alcohol | 139115-90-5 | 99.5% | C4H9N3O2 | 250 MG
Azido-PEG2-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Clorgyline hydrochloride | 17780-75-5 | 99.9% | C13H16Cl3NO | 1 ML
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research. It exhibits minimal effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. This compound contains an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Irreversible and selective monoamine oxidase A (MAO-A) inhibitor
- Used for scientific research
- Minimal impact on conjugated dopamine (DA) in rat striatum slices
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Stable under recommended storage conditions
Medchemexpress LLC Azido-PEG9-alcohol | 1984776-37-5 | 99.9% | C18H37N3O9 | 100 MG
Azido-PEG9-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating an Azide group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It is also capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
![Medchemexpress LLC Ethanol, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 86770-67-4 | 98.9% | 219.24 | 10 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000401155-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanol, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- | 86770-67-4 | 98.9% | 219.24 | 10 G
Azido-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs employ two ligands linked by a linker-one for an E3 ubiquitin ligase and another for the target protein-to selectively degrade target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Azido-PEG24-alcohol | 2415674-94-9 | 98.0% | C48H97N3O24 | 25 MG
Azido-PEG24-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Features an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
- Useful for cancer targeted therapy research
Medchemexpress LLC Bobcat339 hydrochloride | 2436747-44-1 | 99.6% | 334.20 | 1 ML
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of the TET enzyme, with IC50 values of 33 μM for TET1 and 73 μM for TET2. It is valuable in the field of epigenetics and serves as a foundation for developing new therapeutics targeting DNA methylation and gene transcription.
- Potent and selective cytosine-based inhibitor of TET enzyme.
- Useful in epigenetics research.
- Serves as a starting point for new therapeutics targeting DNA methylation and gene transcription.
- Inhibitory activity is directly related to Cu(II) content; the Bobcat339-copper mixture shows significantly higher TET inhibition than either alone.
- Significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells at 10 μM for 24 hours.
Medchemexpress LLC Clorgyline hydrochloride | 17780-75-5 | 99.9% | C13H16Cl3NO | 100 MG
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) used in scientific research. It is structurally related to Pargyline. It has little effect on the amounts of conjugated dopamine (DA) in superfusate of slices from rat striatum. It contains an Alkyne group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. This product is for research use only, not sold to patients.
- Irreversible and selective inhibitor of monoamine oxidase A (MAO-A)
- Used in scientific research
- Structurally related to Pargyline
- Has little effect on conjugated dopamine (DA) in superfusate of slices from rat striatum
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Clorgyline hydrochloride | 17780-75-5 | 99.9% | C13H16Cl3NO | 50 MG
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) used in scientific research. It has minimal effect on conjugated dopamine (DA) amounts in superfusates of rat striatum slices. This compound contains an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Irreversible and selective inhibitor of monoamine oxidase A (MAO-A)
- Structurally related to Pargyline
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide groups
- Increases nicotine infusions and motivation to obtain nicotine in rats at 2 mg/kg daily for 28 days
- Pretreatment with 1 mg/kg intravenously for 1 hour has little effect on the efflux of conjugated dopamine (DA) and p-tyramine-evoked release of conjugated DA from slices of rat striatum