Alcohols and polyols
Medchemexpress LLC Carboxyatractyloside tripotassium | 77228-71-8 | 885.09 | 1 MG
Carboxyatractyloside tripotassium is a diterpenoid that can be isolated from plants of the genus Xanthium. It acts as an ADP/ATP carrier inhibitor, specifically inhibiting mitochondrial ADP/ATP transport. This compound promotes ROS production, induces Ca2+ release, and leads to mitochondrial dysfunction. In rats, Carboxyatractyloside tripotassium has been observed to induce lethargy, weakness, and epileptic seizures.
- Inhibits mitochondrial ADP/ATP transport.
- Promotes production of reactive oxygen species (ROS).
- Induces Ca2+ release.
- Leads to mitochondrial dysfunction.
- Can be isolated from Xanthium plants.
Medchemexpress LLC Ceftiofur hydrochloride | 103980-44-5 | MFCD04038020 | 98.43% | C19H18ClN5O7S3 | 100 MG
Ceftiofur hydrochloride is an inhibitor of bacterial cell wall synthesis that targets bacterial penicillin-binding proteins (PBPs). It exhibits anti-inflammatory effects in endotoxemia. Its bactericidal action stems from inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Additionally, Ceftiofur hydrochloride can inhibit the activation of NF-κB and MAPKs, which consequently reduces the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.
- Targets bacterial penicillin-binding proteins (PBPs).
- Exhibits bactericidal effects by inhibiting bacterial cell wall peptidoglycan synthesis.
- Leads to bacterial cell lysis.
- Possesses anti-inflammatory properties by inhibiting NF-κB and MAPK activation.
- Reduces the secretion of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
Medchemexpress LLC Saikogenin D | 5573-16-0 | 1 MG
Saikogenin D is isolated from Bupleurum chinense and possesses anti-inflammatory effects. It activates epoxygenases, converting arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, which then secondarily inhibit prostaglandin E2 (PGE2) production. It also leads to an elevation of intracellular calcium ([Ca2+]i) due to Ca2+ release from intracellular stores.
- Inhibits PGE2 production in C6 rat glioma cells
- Elevates intracellular calcium in C6 rat glioma cells
Medchemexpress LLC Alectinib hydrochloride | 1256589-74-8 | 99.9% | 25 MG
Alectinib hydrochloride is a potent, selective, and orally available ALK inhibitor. It demonstrates effective central nervous system (CNS) penetration.
- Potent and selective ALK inhibitor
- Orally available
- Inhibits ALK F1174L and ALK R1275Q
- Effective central nervous system (CNS) penetration
- Reduces cell activity in a dose-dependent manner
- Leads to dose-dependent tumor growth inhibition and regression
Medchemexpress LLC Imidapril hydrochloride | 89396-94-1 | 99.9% | 25 MG
Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. It suppresses the conversion of angiotensin I to angiotensin II, leading to a reduction in total peripheral resistance and systemic blood pressure.
- Orally active ACE and MMP-9 inhibitor
- Reduces total peripheral resistance and systemic blood pressure
- Used for hypertension, type 1 diabetic, nephropathy, and chronic heart failure research
Medchemexpress LLC Epz004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 5 MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. It reduces the levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression.
- Selectively inhibits the proliferation of MLL rearrangement cells
- Promotes the differentiation and subsequent apoptosis of leukemia cells
- Can be utilized for leukemia research
- Potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM
- Remarkable selectivity for DOT1L over other HMTs
Selleck Chemical LLC Inbrx-105-A4023-1MG
Inbrx-105 is a recombinant humanized bispecific antibody targeting programmed death-ligand 1 (PD-L1) and 4-1BB with potential checkpoint inhibitory immunostimulating and antineoplastic activities By binding to 4-1BB on activated T lymphocytes and PD-L1 on tumor cells INBRX-105 enhances T-cell co-stimulation and inhibits PD-L1-mediated T-cell inhibition potentially leading to reduced tumor growth INBRX-105 exhibits antitumor efficacy and increased T-cell frequency in patients with solid tumors and in in-vivo MW 101 9 KD
Medchemexpress LLC OP-5244 | 2381268-71-7 | 99.1% | C19H29ClN5O9P | 10MG
This compound is a potent, orally active CD73 (ecto-5'-nucleotidase, NT5E) inhibitor developed for cancer and immunology research. It blocks adenosine production to reverse immunosuppression and demonstrates low-nanomolar biochemical potency.
- Potent CD73 inhibition with low-nanomolar biochemical potency.
- Orally bioavailable in preclinical studies.
- Reverses adenosine-mediated immunosuppression to enhance immune responses.
- High reported purity suitable for research applications.
- Available in small-quantity packages for screening and lead optimization.
Medchemexpress LLC Sultopride hydrochloride | 23694-17-9 | 99.9% | 390.93 | 50 MG
Sultopride hydrochloride is a selective antagonist of the dopamine D2 receptor. It has shown increased levels of DOPAC and HVA in the striatum, nucleus accumbens, and medial prefrontal cortex in treated rats.
- Acts as a selective antagonist of dopamine D2 receptor.
- Demonstrates high purity of 99.92%.
- Soluble in water and DMSO for in vitro applications.
- Suitable for in vivo studies with protocol for PBS solubility.
- Available in solid form, white to off-white in appearance.
- Stored at 4°C, sealed, away from moisture.
Medchemexpress LLC Yohimbine (Hydrochloride) | 65-19-0 | 99.9% | 390.90 | 1 G
Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor that functions by blocking both pre- and post-contact alpha-2 renal adenomatase receptors. This action leads to the release of renal adenoma and multiple sclerosis, and the compound can be utilized in animal modeling for hypertension research.
- Alpha-2 renal adenomatase receptor inhibitor
- Blocks pre- and post-contact alpha-2 renal adenomatase receptors
- Purity of 99.9%
- Solid appearance
- Color: white to light yellow
- Used in animal modeling for hypertension
Medchemexpress LLC Pociredir hydrochloride | 2490676-19-0 | 99.9% | 439.87 | 5 MG
Pociredir hydrochloride (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). It can induce HbF protein expression in cell and murine models, making it suitable for research into select hemoglobinopathies, including sickle cell disease and β-thalassemia. It inhibits PRC2 by binding to EED, which leads to robust HbF protein expression.
- Potent and orally active EED inhibitor
- Induces HbF protein expression in cell and murine models
- Useful for research on sickle cell disease and β-thalassemia
- Inhibits PRC2 by binding to EED
Apexbio Technology LLC Betamethasone Dipropionate 5593-20-4 100mg
Betamethasone Dipropionate (CAS 5593-20-4) is a synthetic glucocorticoid receptor agonist targeting intracellular glucocorticoid receptors It is designed to activate these receptors thereby modulating inflammatory and immune response pathways Betamethasone Dipropionate exerts its biological activity primarily through enhancement of glucocorticoid receptor-mediated gene transcription leading to suppression of inflammatory mediator production and inhibition of inflammatory cell recruitment Based on these pharmacological properties Betamethasone Dipropionate holds research potential in investigations of glucocorticoid signaling inflammatory skin disorders (such as dermatosis) and topical drug formulation research aimed at optimizing local delivery while minimizing systemic effects
Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 g/mol | C20H32ClN3O | 10 MG
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist used in research. It promotes fibroblast proliferation and increases TGF-β1, NALP3, collagen-1, and α-SMA expression in vitro, and reduces neuronal loss and inflammatory infiltration in animal models.
- Orally active TGF-β signaling agonist for in vivo and in vitro studies.
- Promotes fibroblast proliferation and extracellular matrix marker expression.
- Demonstrated neuroprotective effects in animal disease models.
- High purity suitable for research applications.
- Soluble in DMSO, water, and PBS with ultrasonic assistance.
Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 25 MG
Eperisone Hydrochloride is an orally active antispastic agent that also exhibits a vasodilator effect. It is used in research for muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist and also shows antagonism for human P2X3. Eperisone Hydrochloride functions by relaxing both skeletal and vascular smooth muscles, leading to various effects such as reduced myotonia, improved circulation, and suppression of the pain reflex.
- Antispastic agent
- Vasodilator effect
- P2X7 receptor antagonist
- P2X3 antagonist
- Muscle relaxation
- Therapeutic effects
- Research use only
Medchemexpress LLC Skf-34288 (hydrochloride) | 320386-54-7 | 98.6% | 50 MG
SKF-34288 hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor with a Ki of 2-9 μM. It functions as a potent hypoglycemic agent by inhibiting glucose synthesis. Additionally, it inhibits Asn metabolism, leading to an increase in amino acids and amides.
- Inhibits C2C12 cell proliferation
- Induces myogenic differentiation of C2C12 cells
- Reduces mRNA expression of Pck2 and genes associated with serine biosynthesis
- Reduces blood glucose in starved rats
- Neutralizes Salbutamol-mediated hyperglycaemia in rabbits
- Reduces Pyruvate-induced blood glucose level in rats