Cumenes
Medchemexpress LLC Thymopentin (acetate) | 89318-88-7 | 10 MG
Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of the thymic cortex and medulla. It is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. It enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs).
- Biologically active peptide
- Effective immunomodulatory agent
- Short plasma half-life of 30 seconds
- Enhances generation of T-cell lineage from human embryonic stem cells (hESCs)
- High purity (99.95%)
Medchemexpress LLC Thymopentin acetate | 89318-88-7 | 50 MG
Thymopentin acetate is a biologically active peptide primarily secreted by the epithelial cells of the thymic cortex and medulla. It functions as an effective immunomodulatory agent, characterized by a short plasma half-life of 30 seconds. This compound also enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs).
- Biologically active peptide
- Functions as an effective immunomodulatory agent
- Characterized by a short plasma half-life of 30 seconds
- Enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs)
Medchemexpress LLC SU-4942 | 76086-99-2 | 99.6% | 300.15 | 50 MG
SU-4942 is a tyrosine kinase signal modulator that inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells.
- Tyrosine kinase signal modulator
- Inhibits VEGF- and ECGF-induced mitogenesis in endothelial cells
- Solid appearance
- Light yellow to yellow color
- Molecular weight: 300.15
- Purity: 99.6%
Medchemexpress LLC Brite-338733 | 503105-88-2 | 98.9% | 433.59 | 10 MG
BRITE-338733 is an inhibitor of E. coli RecA ATPase activity (IC50: 4.7 μM). It also inhibits the ATP hydrolysis activity of RSC chromatin remodeling enzyme by binding to its ATP-binding pocket and DNA (IC50: 0.316 μM). BRITE-338733 exhibits cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells. It can be used in studies on antibacterial adjuvants and anticancer research.
- Exhibits strong and stable binding affinity for the ATPase domain of Sth1, the catalytic subunit of the yeast RSC complex.
- Potently inhibits the ATP hydrolysis activity of purified yeast RSC complex.
- Exhibits cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-231.
Medchemexpress LLC Karanjin | 521-88-0 | 5 MG
Karanjin is an orally active furanoflavonoid isolated from Leguminosae plants. It exhibits a range of biological activities including anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, and neuroprotective properties. It also functions as an insect repellent and acaricide, making it suitable for various research applications.
- Orally active furanoflavonoid
- Isolated from Leguminosae
- Anti-diabetic, anti-cancer, anti-inflammatory, antioxidant properties
- Neuroprotective, anti-ulcer, and anticolitis effects
- Insect repellent, insecticidal, and acaricide activity
- Enhances glucose uptake; inhibits PTPase
- Induces apoptosis; blocks cell cycle in cancer cells
- Decreases reactive oxygen species (ROS)
- Reduces blood glucose and joint injury in animal models
- Improves learning and memory
Medchemexpress LLC BRITE-338733 | 503105-88-2 | 98.9% | 433.59 | 100 MG
BRITE-338733 is an inhibitor of E. coli RecA ATPase activity (IC50: 4.7 μM) and also inhibits the ATP hydrolysis activity of RSC chromatin remodeling enzyme by binding to its ATP-binding pocket and DNA (IC50: 0.316 μM). It exhibits cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells and can be used in studies on antibacterial adjuvants and anticancer research.
- Inhibits E. coli RecA ATPase activity.
- Inhibits ATP hydrolysis activity of RSC chromatin remodeling enzyme.
- Exhibits cytotoxicity against breast cancer cells (MCF-7 and MDA-MB-231).
- Useful for studies on antibacterial adjuvants and anticancer research.
- Shows strong and stable binding affinity for the ATPase domain of Sth1.
- Potently inhibits ATP hydrolysis activity of purified yeast RSC complex.
Medchemexpress LLC FBPase-1 inhibitor-1 | 883973-99-7 | 99.1% | 377.63 | 100 MG
FBPase-1 inhibitor-1 (Compound 1) is an allosteric FBPase-1 inhibitor that blocks gluconeogenesis by inhibiting FBPase-1. It is suitable for the research of type 2 diabetes.
- Potently inhibits human FBPase-1 activity (IC50 of 3.3 or 3.9 μM)
- Blocks gluconeogenesis in H4IIE rat hepatoma cells
- Ideal for type 2 diabetes research
- Appearance: white to off-white solid
Medchemexpress LLC Karanjin | 521-88-0 | MFCD00017406 | 99.9% | 292.29 g/mol | C18H12O4 | 10 MG
Karanjin is a natural furanoflavonol used in research to modulate cellular pathways and induce apoptosis. It is reported to have antidiabetic, anti-inflammatory, antioxidant, and anticancer activities and is supplied for in vitro pharmacology and pathway modulation studies.
- Natural furanoflavonol with bioactive properties.
- Modulates AMPK and can induce apoptosis in cell-based assays.
- Reported activities include antidiabetic, anti-inflammatory, antioxidant, and anticancer effects.
- High purity suitable for research use; soluble in DMSO.
- Available in small mass pack sizes tailored for laboratory experiments.
Medchemexpress LLC HY-14166 5mg Medchemexpress, MK-886 CAS:118414-82-7 Purity:>98%
Medchemexpress, HY-14166 5mg MK-886 CAS:118414-82-7 MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis[2][3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Tetrahydropiperine | 23434-88-0 | MFCD17167032 | 99.4% | 289.37 g·mol-1 | C17H23NO3 | 10 MG
Tetrahydropiperine is a research-grade small molecule used to probe inflammatory and survival signaling pathways in cellular and biochemical studies. It acts on NF-κB and MAPK signaling and modulates the PI3K/Akt/mTOR pathway.
- Selective inhibitor of NF-κB and MAPKs, useful for pathway studies.
- Modulates PI3K/Akt/mTOR signaling for research on cell survival.
- High purity solid, suitable for analytical and cellular assays.
- Available in small research pack sizes for screening and mechanism-of-action work.
- Molecular weight approximately 289.37 g·mol-1 and formula C17H23NO3.
Medchemexpress LLC DiAzKs (H-L-photo-lysine) | 1253643-88-7 | 99.9% | 272.30 g/mol | C11H20N4O4 | 10 MG
DiAzKs (H-L-photo-lysine) is a diazirine-containing lysine derivative used as a UV-activated photo-crosslinking probe for capturing and mapping protein-protein interactions both in vitro and in living cells.
- Photo-activatable amino acid enabling covalent capture of interacting proteins.
- Site-selective incorporation into proteins for targeted crosslinking experiments.
- High purity at 99.9% for reliable experimental results.
- Molecular weight 272.30 g/mol and chemical formula C11H20N4O4.
- CAS number 1253643-88-7 for unambiguous identification.
- Store protected from light at 4°C; stable longer-term in solution at -80°C.
Medchemexpress LLC ML-193 | 713121-80-3 | 99.7% | 527.59 | 1 ML
ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, demonstrating more than 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It has been shown to improve motor and sensorimotor deficits in Parkinson's disease (PD) rat models.
- Inhibits β-arrestin trafficking induced by L-α-lysophosphatidylinositol and ML186.
- Decreases LPI-mediated ERK1/2 phosphorylation in U2OS cells.
- Attenuates GPR55 agonists induced increases in hNSCs proliferation rates.
- Attenuates ML184-induced increases in hNSCs differentiation.
- Attenuates sensorimotor deficits and slip steps in Parkinson's disease rat models.
- Increases motor coordination in Parkinson's disease rat models.
Medchemexpress LLC Butin | 21913-99-5 | 5 MG
Butin is a major biologically active flavonoid isolated from the heartwood of *Dalbergia odorifera*. It exhibits oral activity and possesses strong antioxidant, antiplatelet, and anti-inflammatory properties. It has been shown to significantly alleviate myocardial infarction, improve heart function, and prevent diabetes-induced cardiac oxidative damage in rats.
- Isolated from the heartwood of *Dalbergia odorifera*.
- Exhibits strong antioxidant activity.
- Possesses antiplatelet activity.
- Has anti-inflammatory activity.
- Alleviates myocardial infarction.
- Improves heart function.
- Prevents diabetes-induced cardiac oxidative damage in rats.
- Reduces cell apoptosis and death caused by ischemia/reperfusion injury.
- Disrupts interaction between Nrf2 and Keap1.
- Increases expression of antioxidant genes.
- Purity: 99.34%.
Medchemexpress LLC Demethylzeylasteral | 107316-88-1 | MFCD16660658 | 99.9% | 480.59 | C29H36O6 | 10 MG
Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii that functions as an apoptosis inducer and has reported anti-inflammatory and antitumor activities. Supplied as a high-purity solid for research applications, it is suitable for use in biochemical and cell-based studies when prepared according to laboratory protocols.
- Apoptosis inducer with reported anti-inflammatory and antitumor activity.
- CAS number 107316-88-1 for unambiguous identification.
- Molecular formula C29H36O6; molecular weight 480.59.
- High purity (≈99.9%) in solid form, suitable for experimental work.
- Available in multiple sizes, including 10 mg and millimolar DMSO solutions.
- Storage: powder at 4°C to -20°C; in solvent store at -80°C for long-term stability.
- Intended for research use only; not for human or clinical applications.
Medchemexpress LLC Ro 5212773 (EPPTB) | 1110781-88-8 | 99.85% | 378.39 | 100 MG
Ro 5212773 (EPPTB) is a potent and selective trace amine-associated receptor 1 (TAAR1) antagonist (Ki=0.9 nM for mouse TAAR1), with no significant effects on other TAARs. TAAR1 is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids. This compound suppresses the excitability of hippocampal pyramidal neurons and reduces seizure-like events (SLEs) and seizure activity.
- Blocks TAAR1-mediated activation of an inwardly rectifying K+ current.
- Potently antagonizes cAMP production induced by activating mouse TAAR1 (IC50=27.5 nM).
- Dose-dependently reduces cAMP levels in HEK293 cells without TAAR1 agonist (IC50= 19 nM).
- More potent in antagonizing cAMP production by mouse TAAR1 compared to rat (IC50= 4539 nM) and human (IC50= 7487 nM) TAAR1.