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Filtered Search Results
Medchemexpress LLC N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide | 935881-37-1 | MFCD17676151 | 98.5% | 312.36 g/mol | C18H20N2O3 | 5 MG
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AR-42 is a potent pan-histone deacetylase (HDAC) inhibitor used in preclinical research to study epigenetic regulation, acetylation status, and related signaling pathways. It induces growth inhibition, cell-cycle arrest, and apoptosis in multiple cancer cell lines and is supplied as a purified research chemical for in vitro and in vivo studies.
- Potent pan-HDAC inhibitor with reported IC50 approximately 16 nM.
- Orally bioavailable and active in preclinical models.
- Induces growth inhibition, cell-cycle arrest, and apoptosis.
- Promotes hyperacetylation of histones H3 and H4, and α-tubulin.
- Supplied as a high-purity research chemical (~98.5%).
- Soluble in common organic solvents such as DMSO and ethanol for assay preparation.
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Medchemexpress LLC Abemaciclib metabolite M2 (LSN2839567) | 1231930-57-6 | MFCD32067988 | 99.8% | 478.54 g·mol⁻1 | C25H28F2N8 | 5 MG
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Abemaciclib metabolite M2 is a research-grade analytical standard and a primary metabolite of the CDK4/6 inhibitor abemaciclib. It is supplied for analytical, biochemical, and preclinical research applications where an authentic metabolite reference is required. The compound shows potent CDK4 and CDK6 inhibition and is provided at high chemical purity suitable for quantitative assays.
- Potent CDK4 inhibition (IC50 1.2 nM).
- Potent CDK6 inhibition (IC50 1.3 nM).
- High purity suitable for analytical work (99.75%).
- Molecular formula C25H28F2N8; molecular weight 478.54 g·mol⁻1.
- Intended for metabolite profiling, analytical method development, and preclinical studies.
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Medchemexpress LLC Cdk12-in-3 | 2220184-50-7 | MFCD31746915 | 99.9% | 470.52 g/mol | C23H28F2N8O | 5 MG
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CDK12-IN-3 is a small-molecule inhibitor selective for cyclin-dependent kinase 12 (CDK12) used in research on transcriptional regulation and DNA damage response. It inhibits CDK12 enzymatic activity (reported IC50 491 nM), impacts phosphorylation of the RNA polymerase II CTD Ser2, and is supplied in high purity for biochemical and cell-based studies.
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Medchemexpress LLC CCR2 antagonist 4 (hydrochloride) | 1313730-14-1 | MFCD16618399 | 99.9% | 476.32 | C21H22Cl2F3N3O2 | 5 MG
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CCR2 antagonist 4 hydrochloride is a small-molecule research compound that selectively antagonizes the chemokine receptor CCR2b. It is used to study CCR2-mediated chemotaxis and inflammatory signaling and is supplied as a white to off-white solid with high reported purity and defined physicochemical data.
- Potent CCR2b antagonist with reported IC50 180 nM.
- Inhibits MCP-1-induced chemotaxis (IC50 24 nM).
- High purity (99.91%).
- White to off-white solid appearance.
- Molecular weight 476.32.
- Available in small research pack sizes including 5 mg.
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Medchemexpress LLC Desmosterol | 313-04-2 | MFCD00056432 | 99.8% | 384.64 g/mol | C27H44O | 5 MG
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Desmosterol is an endogenous sterol and direct precursor to cholesterol in the Bloch biosynthetic pathway. It is used as a research reagent to probe cholesterol biosynthesis, nuclear receptor signaling, and lipid metabolism in biochemical and cell-based studies.
- High purity (>99.8%) suitable for analytical and biological assays.
- Molecular weight 384.64 g/mol; formula C27H44O.
- Acts as an LXR activator and SREBP pathway probe.
- Provided as a 5 mg reagent for small-scale experiments.
- Compatible with biochemical assays and lipid metabolism studies.
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Medchemexpress LLC Ono-2952 | 895169-20-7 | MFCD32661907 | 99.5% | 398.9 g/mol | C22H20ClFN2O2 | 5 MG
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ONO-2952 is a potent, selective, orally active translocator protein 18 kDa (TSPO) antagonist used in pharmacology research. It displays low-nanomolar binding affinity to rat and human TSPO and has been evaluated in studies related to gastrointestinal pain and irritable bowel syndrome.
- Potent TSPO antagonist with Ki in the low nanomolar range.
- High chemical purity (≈99.5%).
- Molecular formula C22H20ClFN2O2; mol wt 398.9 g/mol.
- Available as solid and as 10 mM solution in DMSO for stock preparation.
- Supplied in small research quantities suitable for assay development.
- Characterized for identity (CAS 895169-20-7) with supporting spectral data.
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Medchemexpress LLC Enavogliflozin | 1415472-28-4 | 98.4% | 446.92 g·mol⁻¹ | C24H27ClO6 | 5 MG
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Enavogliflozin is an orally active, selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor developed for treatment of type 2 diabetes and related metabolic disorders. The compound is provided to researchers as a solid powder and as concentrated solution formats for in vitro and translational studies, and it has been characterized in peer-reviewed studies and regulatory entries.
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Medchemexpress LLC (R)-ONO-2952 | 2988224-39-9 | MFCD34676563 | 99.8% | 398.86 | C22H20ClFN2O2 | 5 MG
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(R)-ONO-2952 is the R-enantiomer of ONO-2952, a translocator protein 18 kDa (TSPO) antagonist developed for research into stress-related and irritable bowel syndrome indications. Supplied as a white to off-white solid, the compound has molecular formula C22H20ClFN2O2, molecular weight 398.86, and supplier-reported purity of approximately 99.8%, with recommended low-temperature storage for long-term stability.
- High reported purity suitable for analytical and pharmacology studies.
- R-enantiomer provided for stereochemistry-specific experiments.
- Solid powder form with defined storage conditions for stability.
- Documented molecular formula and molecular weight for formulation and dosing calculations.
- Suitable as a reference standard in preclinical TSPO research.
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Medchemexpress LLC Tetrahydrodeoxycorticosterone | 567-03-3 | MFCD00067604 | 99.5% | 334.49 g/mol | C21H34O3 | 5 MG
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Tetrahydrodeoxycorticosterone (THDOC) is an endogenous neurosteroid and a potent positive allosteric modulator of the GABAA receptor. It demonstrates strong neuroinhibitory effects and is used in biochemical and pharmacological research to investigate GABAergic signaling, neurosteroid modulation, and central nervous system activity. Handle according to safety data sheet recommendations and store protected from light.
- Potent positive allosteric modulator of GABAA receptor.
- Used to study GABAergic signaling and neurosteroid mechanisms.
- Exhibits neuroinhibitory, sedative, and anxiolytic activity.
- Supplied as a research-grade solid with specified purity (≈99.5%).
- Store protected from light at 4°C; in solvent: -80°C up to 6 months.
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Medchemexpress LLC Agi-41998 10Mg | HY-145778-10MG
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Agi-41998 10Mg
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Medchemexpress LLC Acetamide, N-[2-[[4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-1,3,5-triazin-2-yl)amino]ethyl] | 2767424-13-3 | 98.0% | C21H23N5O2 | 10MG
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PD-L1-IN-1 is a small-molecule inhibitor of the PD-1/PD-L1 immune checkpoint intended for research use. It binds PD-L1, shows an IC50 of 115 nM, enhances IFN-γ release and peripheral blood mononuclear cell-mediated killing of PD-L1-expressing cancer cells, and induces apoptosis while showing low cytotoxicity in healthy cells.
- Potent PD-L1 inhibition (IC50 115 nM).
- Enhances IFN-γ release and immune cell-mediated tumor cell killing.
- Induces apoptosis in PD-L1-expressing cancer cell lines.
- Low cytotoxicity in noncancerous cells.
- High solubility in DMSO for assay preparation.
- Defined storage recommendations for powder and solutions.
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Medchemexpress LLC Oxfbd04 | 2231747-03-6 | 99.0% | C17H16N2O3 | 10MG
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OXFBD04 is a small-molecule BET bromodomain ligand that inhibits BRD4 and shows modest affinity for the CREBBP bromodomain. It is intended for research use and has reported analytical data including CAS 2231747-03-6, molecular formula C17H16N2O3, molecular weight 296.32, and reported purity ~98.99%.
- Potent BRD4 inhibitor for epigenetic research.
- Modest affinity for the CREBBP bromodomain.
- High reported purity (≈98.99%).
- Soluble ≥250 mg/mL in DMSO for formulation convenience.
- Available in small pack sizes suitable for screening.
- Storage conditions recommended for powder and solution stability.
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Medchemexpress LLC N-cyclobutyl-N-(4-ethylphenyl)-4-hydroxy-2-(oxan-4-yl)-3,4-dihydro-2H-chromene-6-sulfonamide | 2230779-18-5 | 99.3% | C26H33NO5S | 10MG
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RORγt inverse agonist 23 is a potent, selective, orally available small-molecule inverse agonist of the retinoic acid receptor-related orphan receptor γt (RORγt), intended for preclinical research into RORγt-mediated immune signaling. The compound is provided as a characterized solid with associated structural identifiers to support reproducible research.
- Potent, selective inverse agonist of RORγt.
- Orally available small-molecule suitable for in vivo and in vitro studies.
- High purity (~99.3%).
- Multiple pack sizes including mg-scale and DMSO solutions.
- Supplied with structural identifiers for unambiguous identification.
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Medchemexpress LLC Carboxylesterase-IN-3 | 2764748-92-5 | 98.3% | C11H6Cl2N4OS | 10MG
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Carboxylesterase-IN-3 is a potent Notum (carboxylesterase) inhibitor supplied as a high-purity research compound for in vitro pharmacology and biochemical assays. It exhibits reported IC50 ≤ 10 nM and is provided as a solid powder with documented solubility and storage conditions for assay preparation (CAS 2764748-92-5; formula C11H6Cl2N4OS; Mw 313.16).
- High purity: 98.3%.
- Potent Notum (carboxylesterase) inhibition, IC50 ≤ 10 nM.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance may be required.
- Supplied as a powder suitable for formulation into assay solutions.
- Recommended storage: powder at -20°C for long-term stability.
- Available in multiple milligram-scale pack sizes for research use.
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Medchemexpress LLC Etz (C3-CA-DTZ) | 2989379-61-3 | MFCD00072662 | 99.8% | C34H28N6O6 | 10MG
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ETZ (C3-CA-DTZ) is a luciferase prosubstrate activatable in vivo by nonspecific esterases to enhance brain delivery of luciferin. It is supplied as a light yellow to orange solid with high purity and is soluble in DMSO, making it suitable for preparing concentrated stocks for in vivo bioluminescence experiments focused on brain imaging.
- Activatable in vivo by nonspecific esterases to enhance brain delivery.
- High purity suitable for sensitive assays.
- Soluble in DMSO at ≥100 mg/mL for concentrated stock preparation.
- Solid appearance facilitates handling and storage.
- Storage-stable when sealed and protected from moisture and light.
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