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Filtered Search Results
MEDCHEMEXPRESS LLC EGFR-IN-17 5mg | 2817679-31-3 | 568.01 | C27H31ClN7O3P | 5 MG
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EGFR-IN-17 is a potent, selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) developed to overcome C797S-mediated resistance in mutant EGFR variants. It is intended for research use only and is supplied as a solid or as a DMSO solution for in vitro studies.
- Potent EGFR inhibition (IC50 0.0002 μM).
- Active against C797S, T790M, and L858R EGFR mutants.
- Molecular formula C27H31ClN7O3P and molecular weight 568.01.
- High purity (98.18%) and off-white to light yellow solid.
- Available as small solid quantities (e.g., 5 MG) and as 10 mM solution in DMSO.
- Soluble in DMSO (12.5 mg/mL); ultrasonic warming may be required.
- Recommended storage: powder at -20 °C (up to 3 years); in solvent at -80 °C for long-term.
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MEDCHEMEXPRESS LLC MALAT1-IN-1 50mg | 827327-28-6 | 50 MG
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MALAT1-IN-1 is a small-molecule inhibitor of the MALAT1 long non-coding RNA supplied as a solid research reagent for in vitro studies of MALAT1-mediated pathways and cancer biology. The compound is provided at 50 mg and is characterized by high purity, defined storage conditions, and DMSO solubility suitable for laboratory assays.
- High purity (99.8%).
- Molecular formula C19H21N3O2, molecular weight 323.39 g/mol.
- Appearance: white to light yellow solid.
- Soluble in DMSO (100 mg/mL); ultrasonic agitation may be needed.
- Recommended storage: powder -20 °C (long term) or 4 °C; in solvent -80 °C or -20 °C.
- Supplied as a 50 mg solid and as a 10 mM solution in DMSO.
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MEDCHEMEXPRESS LLC MALAT1-IN-1 100mg | 827327-28-6 | 100 MG
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MALAT1-IN-1 is a research-grade small-molecule inhibitor of the long non-coding RNA MALAT1 that modulates downstream gene expression in a dose-dependent manner. It is supplied for laboratory use in solid and solution formats and is intended for in vitro and preclinical research. Purity is stated as 99.84%.
- Potent, selective modulation of MALAT1-related pathways
- High purity: 99.84% (manufacturer reported)
- Available in multiple pack sizes, including 100 MG
- Supplied as solid and as DMSO solution for flexible dosing
- Includes data sheet, COA, and SDS for experimental support
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MEDCHEMEXPRESS LLC Flupyrimin | 1689566-03-7 | MFCD33395052 | 98.1% | 315.68 g/mol | C13H9ClF3N3O | 5 MG
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Flupyrimin is a small-molecule insecticide research compound that antagonizes insect nicotinic acetylcholine receptors (nAChR), disrupting neuronal signaling in target insects. It is supplied as a solid for laboratory use and is employed in studies of insect neurophysiology and insecticidal activity.
- CAS number: 1689566-03-7.
- Molecular formula: C13H9ClF3N3O.
- Molecular weight: 315.68 g/mol.
- Typical purity: 98.1% (supplier reported).
- Solubility: 250 mg/mL in DMSO; multiple in vivo vehicle formulations reported.
- Storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months).
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MEDCHEMEXPRESS LLC Zagociguat (CY-6463) | 2201048-82-8 | MFCD34676490 | 98.0% | 362.28 g/mol | C16H10F4N6 | 5 MG
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Zagociguat is an orally active, blood-brain barrier-permeable soluble guanylate cyclase (sGC) stimulator used in research to elevate intracellular cGMP and investigate NO-sGC-cGMP signaling pathways. It is employed in preclinical and clinical research addressing neurodegeneration and mitochondrial disease and is supplied in small research pack sizes with defined storage conditions.
- Orally active and brain-penetrant sGC stimulator.
- Increases intracellular cGMP to modulate NO-sGC-cGMP signaling.
- Applicable to neurodegeneration and mitochondrial disease research.
- Provided in small research pack sizes suitable for laboratory studies.
- Powder stable at -20°C for up to 3 years; solutions require low-temperature storage.
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MEDCHEMEXPRESS LLC RORγt inverse agonist 23 | 2230779-18-5 | 99.3% | 471.61 g·mol⁻¹ | C26H33NO5S | 5 MG
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RORγt inverse agonist 23 is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist for research use, used to probe RORγt-mediated signaling and evaluate pharmacological effects in preclinical models.
- Potent and selective inverse agonist of RORγt.
- Orally available in pharmacological models.
- High purity (99.3%) suitable for biochemical and cellular assays.
- Supplied as a white to off-white solid; soluble in DMSO.
- Stable when stored sealed at recommended temperatures.
- Offered in multiple mass formats and pre-made solution aliquots for convenience.
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MEDCHEMEXPRESS LLC Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg | 2891606-02-1 | MFCD34676951 | 99.8% | 915.09 g/mol | C43H70N12O10 | 5 MG
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BM213 is an acetylated octapeptide agonist of the complement C5a receptor 1 (C5aR1) employed in research to stimulate neutrophil activation and promote neutrophil extracellular trap (NET) formation. It is provided as a high-purity solid with characterized molecular properties and solubility suitable for in vitro and in vivo studies.
- Peptide sequence: Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg.
- High purity (99.8%).
- Molecular weight 915.09 g/mol.
- CAS number 2891606-02-1.
- Soluble in water and PBS; may require sonication.
- Storage: solid at -20°C; solutions stored at -80°C for long-term stability.
- For research use only; not for human or diagnostic use.
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MEDCHEMEXPRESS LLC Prx-07034 hydrochloride | 903580-39-2 | 99.0% | 490.44 | C21H29Cl2N3O4S | 5 MG
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PRX-07034 hydrochloride is a research-use small molecule that acts as a potent, selective antagonist of the serotonin 5-HT6 receptor. Supplied as the hydrochloride salt, it is intended for preclinical pharmacology studies investigating cognition, working memory, and receptor pharmacology. The compound is offered in multiple pack sizes and formats and is reported with high purity.
- Potent, selective 5-HT6 receptor antagonist (Ki 4-8 nM; IC50 19 nM).
- High reported purity (98.97%).
- Available in multiple pack sizes and as a 10 mM solution in DMSO.
- Suitable for preclinical studies of cognition and memory.
- For research use only; not for human or veterinary use.
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MEDCHEMEXPRESS LLC (R)-GSK-3685032 | 2170140-50-6 | 99.0% | 420.53 g·mol⁻¹ | C22H24N6OS | 5 MG
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(R)-GSK-3685032 is the R-enantiomer of GSK-3685032, a reversible, DNMT1-selective inhibitor used in epigenetics research to induce loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition. The compound is characterized by a defined molecular formula and high reported purity, and it is supplied for in vitro and preclinical research use.
- Reversible DNMT1-selective inhibitor with reported low-nanomolar activity.
- Induces loss of DNA methylation and downstream transcriptional activation.
- High reported purity and fully characterized molecular properties.
- Available in small, research-scale pack sizes for preclinical studies.
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MEDCHEMEXPRESS LLC CD38 inhibitor 2 | 2597933-78-1 | 98.8% | 384.43 g/mol | C19H24N6O3 | 5 MG
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CD38 inhibitor 2 is a small-molecule inhibitor of the CD38 enzyme with submicromolar potency (IC50 = 0.01-0.1 μM). Provided as a solid research compound and as a 10 mM solution in DMSO, it is intended for in vitro biochemical and cellular studies of CD38-related biology. The compound has formula C19H24N6O3, molecular weight 384.43 g/mol, and is supplied at high purity.
- Potent CD38 inhibition (IC50 0.01-0.1 μM).
- High purity (~98.8%) suitable for biochemical and cellular assays.
- Available as a solid and as a 10 mM solution in DMSO for convenience.
- Supplied in small research quantities (for example, 5 mg) for screening and profiling.
- Molecular formula C19H24N6O3 and molecular weight 384.43 g/mol for experimental planning.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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MEDCHEMEXPRESS LLC Avj16 | 2775241-92-2 | 99.6% | 469.53 | C28H27N3O4 | 5 MG
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AVJ16 is a small-molecule inhibitor of the insulin-like growth factor 2 mRNA binding protein IGF2BP1. It binds IGF2BP1 (reported Kd ≈ 1.4 μM) and has demonstrated inhibition of cancer cell migration, proliferation, colony and spheroid formation, and induction of apoptosis in preclinical in vitro and xenograft studies.
- Targets IGF2BP1 RNA-binding activity (reported Kd 1.4 μM).
- Inhibits proliferation, invasion, and migration of IGF2BP1-expressing cancer cells.
- Suppresses colony formation and spheroid growth in relevant cell lines.
- Induces apoptosis in susceptible cell lines in vitro.
- Demonstrates antitumor activity in xenograft models at reported dosing.
- Available as solid and as a 10 mM solution in DMSO for convenient use.
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MEDCHEMEXPRESS LLC 3-(3,5-dimethylisoxazol-4-yl)-5-(hydroxy(pyridin-3-yl)methyl)phenol | 2231747-03-6 | MFCD32174354 | 99.0% | 296.32 g·mol⁻¹ | C17H16N2O3 | 5 MG
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A small-molecule research compound that acts as a potent and selective BRD4 (BET family) inhibitor, with reported cellular activity (IC50 ≈166 nM) and demonstrated antiproliferative effects in cancer cell assays. Supplied as a high-purity solid for biochemical and cellular research applications.
- Potent BRD4 inhibitor with reported IC50 ≈166 nM.
- Demonstrated antiproliferative activity in cancer cell assays.
- Molecular formula C17H16N2O3; molecular weight 296.32 g·mol⁻¹.
- High purity (98.99%).
- Supplied as a powder suitable for biochemical and cellular studies.
- Recommended storage: powder -20°C (long term) or 4°C (short term); in solvent -80°C.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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MEDCHEMEXPRESS LLC Mlk-in-1 | 1627729-62-7 | 99.1% | 432.49 g·mol⁻¹ | C23H20N4O3S | 5 MG
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MLK-IN-1 is a research-grade small molecule that selectively inhibits mixed lineage kinase 3 (MLK-3). Described in patent US20140256733A1 as compound 68, it is reported to be potent and brain penetrant. The material is intended for laboratory research in both in vitro and in vivo neurobiological studies.
- Selective MLK-3 inhibitor with reported potency.
- Demonstrated brain penetration suitable for neurobiological studies.
- High reported purity of 99.1%.
- Molecular weight 432.49 g·mol⁻¹ and formula C23H20N4O3S.
- Available in small quantities suitable for research use (for example, 5 mg).
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MEDCHEMEXPRESS LLC Nitroflurbiprofen 50mg | 50mg
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Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats
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MEDCHEMEXPRESS LLC Glycyl-Exatecan-d5 hydrochloride | 1883333-57-0 | 99.0% | 1 MG
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Glycyl-Exatecan-d5 hydrochloride is a deuterium-labeled derivative of Glycyl-Exatecan, which is itself a derivative of Exatecan. This compound functions as an anticancer agent, demonstrating significant antitumor activity. It is suitable for research related to various cancers, including solid tumors. It also serves as a tracer and an internal standard for quantitative analytical methods such as NMR, GC-MS, or LC-MS.
- Deuterium labeled compound
- Derivative of Exatecan
- Anticancer agent with significant antitumor activity
- Suitable for solid tumors research
- Functions as a tracer
- Used as an internal standard for quantitative analysis
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