Phenoxy compounds
Medchemexpress LLC Propoxycaine hydrochloride | 550-83-4 | 99.7% | 100 MG
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.
- Sodium channel inhibitor
- Inhibits voltage-gated sodium channels
- Inhibits the ionic flux required for the initiation and conduction of impulses
- Can lead to a loss of sensation
Selleck Chemical LLC Travoprost S3738-2mg
Travoprost (Travoprostum) is a PGF2a analog that was launched as an ophthalmic solution administered topically for the treatment of elevated intraocular hypertension as a result of open-angle glaucoma a common optic neuropathy and a leading cause of blindness It can act as an agonist of prostaglandin F receptor
Medchemexpress LLC Propoxycaine hydrochloride | 550-83-4 | 99.7% | 5 MG
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. Its application can lead to a loss of sensation. This laboratory chemical is intended for research use only and should be handled by qualified and experienced scientists in appropriately equipped and authorized facilities.
- Inhibits voltage-gated sodium channels
- Inhibits ionic flux for impulse initiation and conduction
- Leads to a loss of sensation
- Stable under recommended storage conditions
- Requires personal protective equipment for handling
Medchemexpress LLC HY-12281 5mg Medchemexpress, FPH2 CAS:957485-64-2 Purity:>98%
Medchemexpress, HY-12281 5mg FPH2 CAS:957485-64-2 FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG
Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive CHK1 inhibitor
- Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
- Induces double-stranded DNA breakage and replication catastrophe
- Leads to apoptosis and potent anti-tumor activity
- Inhibits MELK, SIK, BRSK2, and ARK5
- Requires CDC25A and CDK2 for DNA damage
- Causes DNA damage during S-phase
- Inhibits CHK1 and CHK2 autophosphorylation
- Induces cell-cycle shift with H2AX phosphorylation
- Triggers chromosomal fragmentation and replication stress
Medchemexpress LLC Mephenesin | 59-47-2 | 99.69% | 500 MG
Mephenesin is an NMDA receptor antagonist and a central muscle relaxant with antianxiety, muscle-paralyzing, and anticonvulsant effects. It directly affects skeletal muscle fibers, leading to skeletal muscle relaxation and is being researched for its potential in treating spasticity or painful muscle spasms. This product is provided as a white to off-white solid.
- Molecular weight: 182.22
- Formula: C10H14O3
- Appearance: Solid
- Color: White to off-white
- Purity: 99.69%
Apexbio Technology LLC Clofibrate 637-07-0 5g
Clofibrate (CAS 637-07-0) is a small-molecule agonist targeting peroxisome proliferator-activated receptor alpha (PPAR-alpha) It is designed to activate PPAR-alpha thereby regulating lipid and lipoprotein metabolism pathways Clofibrate exerts its biological activity primarily through PPAR-alpha activation leading to enhanced peroxisome proliferation and fatty acid oxidation In both human and mouse models Clofibrate demonstrates agonist activity with EC50 values of 55 M and 500 M respectively Based on these pharmacological properties Clofibrate holds research potential in investigating lipid metabolism triglyceride regulation and the roles of PPAR-alpha signaling in hyperlipidemia and related metabolic disorders
Apexbio Technology LLC Diethylmaleate 141-05-9 100mg
Diethylmaleate (141-05-9) is a small-molecule compound that depletes intracellular glutathione (GSH) modulating cellular redox-sensitive pathways Diethylmaleate exerts its biological activity primarily through induction of oxidative stress and ROS generation leading to modulation of cell cycle apoptosis gene expression and activation of MAPK signaling pathways In vitro studies demonstrate that Diethylmaleate-mediated GSH depletion triggers cell cycle arrest and apoptosis Animal research shows effects on reproductive systems including altered testicular antioxidant status and sperm parameters Based on these pharmacological properties Diethylmaleate holds research potential in studies of oxidative stress redox regulation and toxicology
Medchemexpress LLC Prexasertib dimesylate (LY2606368 dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 100 MG
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor.
- Inhibits CHK2 and RSK1.
- Causes double-stranded DNA breakage and replication catastrophe.
- Induces apoptosis.
- Shows potent anti-tumor activity.
Medchemexpress LLC Prexasertib dimesylate | 1234015-58-7 | MFCD32693943 | 98.9% | 557.60 | C20H27N7O8S2 | 10 MG
Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor supplied as a solid research compound. It causes double-stranded DNA breakage and replication catastrophe that lead to apoptosis, and is offered in multiple solid pack sizes and solution formats for laboratory use. Not for human or clinical use.
- Selective ATP-competitive CHK1 inhibitor.
- Induces DNA double-strand breaks and replication catastrophe.
- High purity: 98.9%.
- Available as solid and as 10 mM solution in DMSO.
- Solubility data provided for in vitro and in vivo protocols.
- Recommended storage: 4°C (solid) and -80°C for stock solutions.
Apexbio Technology LLC Tamoxifen Citrate 54965-24-1 5g
Tamoxifen Citrate (CAS 54965-24-1) is a small-molecule antagonist targeting estrogen receptors (ER) It is designed to competitively bind ER thereby modulating estrogen-mediated signal transduction Tamoxifen Citrate exerts its biological activity primarily by inhibiting the transcriptional activity of estrogen-responsive genes leading to reduced synthesis of factors related to cell growth and angiogenesis In in vitro studies Tamoxifen Citrate demonstrates inhibition of cell proliferation with reported IC50 values typically ranging from 3 to 7 M depending on cell line and experimental conditions Based on these pharmacological properties Tamoxifen Citrate holds research potential in studies of estrogen receptor-dependent signaling pathways and anti-tumor strategies particularly in breast cancer models
Medchemexpress LLC Tirofiban | 144494-65-5 | 98.4% | 440.60 | 50 MG
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist. It inhibits fibrinogen binding to this receptor, leading to antithrombotic activity. It also induces proliferation and migration of endothelial cells by stimulating VEGF production, and significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding to the receptor
- Possesses antithrombotic activity
- Induces proliferation and migration of endothelial cells
- Reduces myocardial no-reflow and ischemia-reperfusion injury
- Alleviates myocardial microvascular structural and endothelial dysfunction
Medchemexpress LLC Betaxolol (hydrochloride) | 63659-19-8 | 98.1% | 100 MG
Betaxolol hydrochloride is a selective beta1 adrenergic receptor blocker used in research for conditions such as hypertension and glaucoma. It functions by selectively blocking beta-1 adrenergic receptors, which primarily affect the heart and kidney, leading to reduced heart rate and blood pressure. Research suggests it may also attenuate anxiety-like behavior during cocaine withdrawal. It is noted to have less systemic beta2- and potentially beta1-adrenergic receptor blockade compared to other similar agents.
- Selective beta1 adrenergic receptor blockade.
- Applicable in hypertension and glaucoma research.
- May be safer for patients with reactive airway disease than some other agents.
- Can attenuate anxiety-like behavior in certain contexts.
Apexbio Technology LLC JW 55 664993-53-7 10mg
JW 55 (CAS 664993-53-7) is a small-molecule inhibitor that targets the poly(ADP-ribose) polymerase (PARP) domains of tankyrase 1 and tankyrase 2 (TNKS1/2) with reported IC50 values of 1 9 M and 0 83 M respectively By inhibiting TNKS1/2 activity JW 55 stabilizes AXIN2 a component of the -catenin destruction complex leading to enhanced degradation of -catenin and suppression of canonical Wnt/ -catenin signaling In vitro JW 55 suppresses Wnt pathway activity in colorectal cancer cells harboring APC or -catenin mutations In vivo it reduces Wnt-driven phenotypes in Xenopus embryos and diminishes polyp formation in APC-mutant mice supporting its utility as a research tool in Wnt/ -catenin signaling and cancer biology
Medchemexpress LLC Quizalofop-p-ethyl ((R)-Quizalofop ethyl) | 100646-51-3 | 99.1% | 200 MG
Quizalofop-P-ethyl is a low-toxicity herbicide, characterized as a highly selective, new type of post-emergence herbicide for dryland crops. It demonstrates high selectivity between gramineous weeds and dicotyledonous crops, offering effective control against gramineous weeds in broadleaf crop fields.
- This compound inhibits the growth of a specific aquatic microorganism and reduces its chlorophyll and protein content.
- It impacts photosynthesis by suppressing the expression of photosynthesis-related genes.
- The compound encourages the expression of a gene related to microcystin, stimulating the synthesis and release of microcystin, which can lead to water environment pollution.
- It also increases MDA content in the aquatic microorganism and enhances the activities of SOD and CAT, inducing oxidative stress.
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