Phenylhydrazines
1,1-Diphenylhydrazine 97.0+%, TCI America™
CAS: 530-50-7 Molecular Formula: C12H12N2 Molecular Weight (g/mol): 184.242 MDL Number: MFCD00044505 InChI Key: YHYKLKNNBYLTQY-UHFFFAOYSA-N PubChem CID: 10739 IUPAC Name: 1,1-diphenylhydrazine SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)N
Medchemexpress LLC (+)-Igmesine hydrochloride | 130152-35-1 | 355.9 | 50 MG
(+)-Igmesine hydrochloride is an orally active and selective sigma receptor ligand with neuroprotective and antidepressant properties.
Medchemexpress LLC Samuraciclib (hydrochloride) | 1805789-54-1 | 99.9% | 430.97 | 50 MG
Samuraciclib hydrochloride is a potent, selective, ATP-competitive, and orally active CDK7 inhibitor with an IC50 of 41 nM. It exhibits selectivity over CDK1, CDK2, CDK5, and CDK9. This compound inhibits the growth of breast cancer cell lines and demonstrates anti-tumor effects, promoting cell apoptosis and inducing cell cycle arrest.
- Potent and selective CDK7 inhibitor (IC50 41 nM)
- Shows selectivity over CDK1, CDK2, CDK5, and CDK9
- Inhibits growth of breast cancer cell lines (GI50 0.2-0.3 μM)
- Promotes cell apoptosis and induces cell cycle arrest
- Inhibits PolII CTD phosphorylation
- Demonstrates anti-tumor effects in animal models
- Leads to complete growth arrest of ER-positive tumor xenografts in combination therapy
Medchemexpress LLC Procainamide hydrochloride | 614-39-1 | 99.5% | C13H22ClN3O | 50 MG
Procainamide hydrochloride is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). It reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes, induces vacuolization in various cell types, and reduces cell proliferation and migration. Additionally, it relaxes airway smooth muscle by activating potassium channels, making it applicable in cancer and arrhythmia research.
- Specific and potent inhibitor of DNA methyltransferase 1 (DNMT1)
- Reactivates tumor suppressor gene expression
- Induces vacuolization in various cell types
- Reduces cell proliferation and migration
- Relaxes airway smooth muscle through potassium channel activation
- Applicable in cancer and arrhythmia research
Medchemexpress LLC Medetomidine (hydrochloride) | 86347-15-1 | 99.9% | 236.74 | 50 MG
Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist with a Ki of 1.08 nM. It exhibits sedative and analgesic effects and can induce peripheral vasoconstriction by activating α2 adrenoceptors on blood vessels.
- Orally active α2-adrenoceptor agonist (Ki: 1.08 nM).
- Possesses sedative and analgesic effects.
- Causes peripheral vasoconstriction through α2 adrenoceptor activation.
- Inhibits aldosterone release from adrenocortical cell suspension in vitro.
- Activates a kicking response in Cyprids in vitro.
- Increases cellular cAMP production by activating β-like receptors in CHO cells in vitro.
- Induces sedation in cats in vivo.
- Shows sedative and analgesic effects in dogs in vivo.
- Protects against Diazinon-induced toxicosis in mice in vivo.
Medchemexpress LLC Fabomotizole hydrochloride | 173352-39-1 | 99.9% | 343.87 | 50 MG
Fabomotizole hydrochloride (CM346 hydrochloride) is a compound recognized for its anxiolytic and neuroprotective properties. It also demonstrates activity against *Giardia lamblia*, showing potential to inhibit giardiasis. While its precise mechanism of action is still being elucidated, research suggests possible involvement in GABAergic pathways, promotion of NGF and BDNF release, antagonism of MT1 and MT3 receptors, sigma agonism, reversible inhibition of MAO-A, and potential interaction with serotonin receptors.
- Anxiolytic activity
- Neuroprotective activity
- Activity against Giardia lamblia with potential to inhibit giardiasis
Medchemexpress LLC Omadacycline (hydrochloride) | 1196800-39-1 | 99.5% | 593.11 | 50 MG
Omadacycline hydrochloride is a first-in-class orally active aminomethylcycline antibacterial, part of the tetracycline class of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
- Broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria.
- Used for research on acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
- Active against strains expressing tetracycline and other antibiotic resistance.
Medchemexpress LLC 2,6-Pyridinedicarboxamide, 4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-, hydrochloride (1:5) | 1781882-65-2 | C31H37Cl5N8O5 | 50 MG
Pyridostatin hydrochloride is a G-quadruplex DNA stabilizing agent that targets DNA and RNA G4s in cells. It promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. This compound targets the proto-oncogene Src, reducing SRC protein levels and SRC-dependent cellular motility in human breast cancer cells. It is suitable for research use only.
- Selective G-quadruplex DNA-binding small molecule
- Induces cell cycle arrest in over 60 different cancer cell lines
- Causes neurite retraction and synaptic loss
- Downregulates BRCA1 protein at the transcriptional level
TARGETMOL CHEMICALS INC PROPARGITE 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Propargite is a pesticide used to kill mites. Propargite induces (beta)-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC 50 of 1 uM [1] . purity: 98%
Medchemexpress LLC Valacyclovir (hydrochloride) | 124832-27-5 | 99.02% | 360.80 | 25 MG
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent effective against herpes simplex, herpes zoster, and herpes B. It inhibits HSV-1 W (50=2.9 μg/ml) and is a prodrug of Aciclovir (HY-17422). This product is intended for research and analytical applications.
- Orally active antiviral agent
- Effective against herpes simplex, herpes zoster, and herpes B
- Inhibits HSV-1 W (50=2.9 μg/ml)
- Prodrug of aciclovir
- Intended for research and analytical applications
Medchemexpress LLC Valacyclovir hydrochloride | 124832-27-5 | 99.02% | 360.80 | 50 MG
Valacyclovir (hydrochloride) (Standard) is the analytical standard of Valacyclovir (hydrochloride), an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. It inhibits HSV-1 W (50=2.9 μg/ml) and is a proagent of Aciclovir. This product is intended for research and analytical applications, commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard
- Orally active antiviral agent
- Effective against herpes simplex, herpes zoster, and herpes B
- Inhibits HSV-1 W (50=2.9 μg/ml)
- Proagent of Aciclovir
- Suitable for research and analytical applications
- Used in HPLC, GC, and MS experiments
TARGETMOL CHEMICALS INC SYM 2081 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes.SYM 2081 is a specific kainate receptor agonist with an IC50 value of 35 nM for [3H]-kainate binding. SYM 2081 depolarizes the muscle and reduces the EPSP amplitude. Purity 99.59%
Medchemexpress LLC Valacyclovir hydrochloride | 124832-27-5 | 99.9% | 360.80 | 1 G
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent effective against herpes simplex, herpes zoster, and herpes B. It inhibits HSV-1 W with a concentration of 50=2.9 μg/ml. Valacyclovir hydrochloride acts as a proagent of Aciclovir.
- Orally active antiviral agent
- Effective against herpes simplex, herpes zoster, and herpes B
- Inhibits HSV-1 W
- Proagent of Aciclovir
Medchemexpress LLC Valacyclovir hydrochloride | 124832-27-5 | 99.9% | 360.80 | 100 MG
Valacyclovir hydrochloride is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. It inhibits HSV-1 W (50=2.9 μg/ml) and is a proagent of Aciclovir.
- IC50 and target: HSV-1, 2.9 μg/mL (IC50).
- In vitro: Uptake is concentration dependent and saturable, with hPEPT1 dominating intestinal transport.
- In vivo: Effective for treating genital herpes (1 g twice daily) and recurrences. A 1 g daily dose is as effective as 2 g daily and can be administered once a day. Studies in immunosuppressed mice showed reduced erythema, eliminated ear paralysis, ear lesions, and death.
Medchemexpress LLC Valacyclovir hydrochloride (Standard) | 124832-27-5 | 99.0% | 360.80 | 5 MG
Valacyclovir (hydrochloride) (Standard) is the analytical standard of Valacyclovir (hydrochloride). This product is intended for research and analytical applications. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. It inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422).
- The compound is the grade of analytical standard, which is the reference standard supplied assay.
- It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.