ZK824859 hydrochloride is a research-stage small-molecule hydrochloride salt that functions as an orally available, selective inhibitor of urokinase plasminogen activator (uPA). Reported potency includes IC50 values of 79 nM for human uPA, 1,580 nM for tPA, and 1,330 nM for plasmin. The compound is supplied as a solid powder for in vitro and in vivo research use.
- Orally available uPA inhibitor.
- Selective activity: human uPA IC50 = 79 nM; tPA = 1,580 nM; plasmin = 1,330 nM.
- Hydrochloride salt form for improved solubility.
- CAS 2436760-76-6; molecular formula C23H23ClF2N2O4; molecular weight 464.89 g·mol-1.
- Common research package sizes include 25 mg and 50 mg.