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Filtered Search Results
Medchemexpress LLC Saxagliptin (hydrochloride) | 709031-78-7 | 99.71% | 351.87 | 1 ML
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Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It has the potential for research in type 2 diabetes mellitus.
- It acts by preventing the degradation of glucagon-like peptide-1, which increases insulin secretion and decreases glucagon secretion.
- Studies have shown that saxagliptin can induce β-cell proliferation.
- It has been observed to increase p-AKT and active β-catenin protein levels, alongside increased c-myc and cyclin D1 protein expression.
- It dose-dependently inhibits plasma DPP-4 activity.
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Medchemexpress LLC AR-M 1000390 hydrochloride | 209808-47-9 | MFCD20926357 | 98.2% | 384.94 g/mol | C23H29ClN2O | 50 MG
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AR-M 1000390 hydrochloride is a potent, highly selective small-molecule agonist of the δ (delta) opioid receptor provided as the hydrochloride salt for research use. It exhibits low-nanomolar potency, is supplied as a white to off-white solid, and is commonly used in in vitro receptor pharmacology and selectivity profiling.
- Potent δ-opioid receptor agonist with EC50 of 7.2 ± 0.9 nM.
- High purity suitable for pharmacological studies (~98.2%).
- Provided as a stable hydrochloride solid, white to off-white.
- Available in multiple milligram sizes for assay flexibility.
- Suitable for in vitro receptor pharmacology and selectivity profiling.
- Recommended sealed storage away from moisture; stable refrigerated.
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Medchemexpress LLC Midaglizole (hydrochloride) | 79689-25-1 | 324.25 | 100 MG
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Midaglizole hydrochloride is a potent alpha2-adrenoceptor antagonist. It is a hypoglycemic agent that increases blood pressure and reduces blood glucose levels in vivo.
- Potent alpha2-adrenoceptor antagonist
- Hypoglycemic agent
- Increases blood pressure in vivo
- Reduces blood glucose levels in vivo
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TARGETMOL CHEMICALS INC ZXH-3-26 1MG
ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer. Purity 98.9%
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Medchemexpress LLC Milnacipran hydrochloride | 101152-94-7 | 99.7% | 25 MG
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Milnacipran hydrochloride is an orally active Serotonin and Norepinephrine reuptake inhibitor. It inhibits monoamine transporters, specifically the norepinephrine transporter and the serotonin transporter, with Ki values of 31 and 8.5 nM, respectively. It also inhibits pERK1/2 activation. Milnacipran hydrochloride exhibits antidepressant, anxiolytic, and analgesic properties and can inhibit biting behavior in mice. It is used in the study of major depressive disorder, anxiety disorders, and neuropathic pain, such as fibromyalgia.
- Orally active serotonin and norepinephrine reuptake inhibitor
- Inhibits monoamine transporters with Ki values of 31 and 8.5 nM
- Inhibits pERK1/2 activation
- Exhibits antidepressant, anxiolytic, and analgesic properties
- Can inhibit biting behavior in mice
- Used in studies for major depressive disorder, anxiety disorders, and neuropathic pain
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Medchemexpress LLC Saxagliptin hydrochloride | 709031-78-7 | 99.7% | 351.87 | 5 MG
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Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It has the potential for type 2 diabetes mellitus research.
- Potent, selective, reversible, competitive, and orally active DPP-4 inhibitor
- Induces β-cell proliferation
- Increases p-AKT and active β-catenin protein levels
- Prevents glucagon-like peptide-1 degradation
- Increases insulin secretion and decreases glucagon secretion
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Medchemexpress LLC Epetraborole hydrochloride | 1234563-16-6 | MFCD28411360 | 99.6% | 273.52 g/mol | C11H17BClNO4 | 100MG
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Epetraborole hydrochloride is a research-grade leucyl-tRNA synthetase (LeuRS) inhibitor supplied as a hydrochloride salt for antibacterial research. It inhibits protein synthesis (reported IC50 = 0.31 μM) and is used in studies of multidrug-resistant gram-negative pathogens. Supplied as a high-purity solid, it requires sealed storage at 4°C and long-term storage in solution at -80°C.
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Medchemexpress LLC Cilobradine hydrochloride | 186097-54-1 | 99.7% | 519.07 | 25 MG
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Cilobradine hydrochloride is an HCN channel blocker that induces cardiac pacemaker currents and produces antidepressant effects. It works by blocking HCN channel currents in cells and can reverse depressive-like behavior in vivo, with effects lasting for about two weeks.
- Induces cardiac pacemaker currents
- Produces antidepressant effects
- Blocks HCN channel currents in HEK293 cells
- Not isoform-specific in steady-state inhibition of different HCN isoforms
- Can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG)
- Can reverse depressive-like behavior
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Medchemexpress LLC TCMDC-135051 hydrochloride | 2705545-47-5 | 98.2% | 508.05 g/mol | C29H34ClN3O3 | 10MM 1ML
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TCMDC-135051 hydrochloride is a small-molecule inhibitor of the Plasmodium falciparum protein kinase PfCLK3, formulated for in vitro research. It is supplied as a solid and is available as a pre-made 10 mM solution in DMSO for biochemical and antiparasitic assays.
- High purity (98.17%) suitable for in vitro assays.
- Molecular weight 508.05 g/mol.
- Molecular formula C29H34ClN3O3.
- Soluble in DMSO (≈164 mM); sonication recommended for complete dissolution.
- Available in multiple solid sizes and as a 10 mM, 1 mL solution in DMSO.
- Intended for PfCLK3 inhibition and antiparasitic research applications.
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Medchemexpress LLC Galidesivir hydrochloride | 222631-44-9 | 99.9% | 301.73 | 25 MG
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Galidesivir hydrochloride is an adenosine analog and a direct-acting antiviral agent that disrupts viral RNA-dependent RNA polymerase (RdRp) activity. It is active in vitro against many RNA viral pathogens, including filoviruses and emerging infectious agents like MERS-CoV, SARS-CoV, and SARS-CoV-2. It inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.
- Adenosine analog
- Direct-acting antiviral agent
- Disrupts viral RNA-dependent RNA polymerase (RdRp) activity
- Active against many RNA viral pathogens
- Inhibits negative-sense RNA viruses
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Medchemexpress LLC Opiranserin hydrochloride (VVZ-149 hydrochloride) | 1440796-75-7 | 99.6% | 430.97 | 50 MG
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Opiranserin hydrochloride (VVZ-149 hydrochloride) is a non-opioid and non-NSAID analgesic candidate. It functions as a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50 values of 0.86 and 1.3 μM, respectively. Additionally, it demonstrates antagonistic activity on rP2X3 (IC50=0.87 μM). It is being developed as an injectable agent for the treatment of postoperative pain and is intended for research use only.
- Functions as dual antagonist of GlyT2 and 5HT2A
- Demonstrates antagonistic activity on rP2X3
- Intended for research use only
- Developed as an injectable agent for postoperative pain
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Ambeed 6Chloro7Hpurine
6-Chloro-7H-purine, 87-42-3, 98%
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Medchemexpress LLC Brombuterol hydrochloride | 21912-49-2 | MFCD10567368 | 99.9% | 402.55 g·mol⁻1 | C12H19Br2ClN2O | 5 MG
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Brombuterol hydrochloride is a β-adrenergic receptor agonist provided as an analytical research standard for laboratory use. It is intended for research purposes and not for human consumption.
- High purity: 99.9%.
- Small pack sizes suitable for analytical assays.
- Molecular weight 402.55 g·mol⁻1.
- CAS number 21912-49-2 for unambiguous identification.
- Store sealed at 4°C; in solution keep at -80°C for long-term storage.
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Medchemexpress LLC Valnivudine hydrochloride | 956483-03-7 | 98.99% | 534.04 | 50 MG
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Valnivudine hydrochloride (FV-100) is a potent, selective, and orally active anti-varicella zoster virus agent. It is a proagent of CF-1743 and exhibits very low toxicity in vivo. It is intended for research use only.
- Potent, selective, and orally active anti-varicella zoster virus agent.
- Proagent of CF-1743.
- Exhibits very low toxicity in vivo.
- Intensely fluorescent when illuminated by wavelengths of 340-380 nm (In Vitro).
- Does not induce biologically relevant respiratory changes or apparent neuropharmacological effects in rats at 50-500 mg/kg; p.o. (In Vivo).
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Medchemexpress LLC Pevonedistat Hydroch 10Mm 1Ml | HY-10484-10MM 1ML
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Pevonedistat Hydroch 10Mm 1Ml
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