Guinea Pig Whole Blood
Cayman Chemical GlycochenodeoxycholIc ACD
A sulfhydryl-reactive biotinylation reagent that forms a reversible disulfide linkage used to label protein cysteines and other substrates that contain sulfhydryl groups easily linked with target substrates at pH 6.5 to 7.5 in buffers such as PBS disulfide linkage can be cleaved by reducing agents
Cayman Chemical DocosahexaenoIc ACD ethyl50mg
A TEAD1 inhibitor (IC50 1.02 nM) inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2 TEAD3 or TEAD4 at 3 UM inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models
Cayman Chemical EIcosapentaenoIc ACD ethyl1mg
An ALDH1A3 inhibitor (IC50 5.14 nM) potentiates glucose-induced insulin secretion from pancreatic islets isolated from patients with type 2 diabetes at 10 UM decreases plasma insulin levels and reduces blood glucose levels in an IPGTT in diabetic db/db male mice at 40 mg/kg per day decreases blood glucose levels and increases plasma insulin levels in a mouse model of high-fat diet-induced obesity at 270 ppm in the diet
Cayman Chemical ArachIdonIc ACD sulfonatS
An M4 muscarinic receptor PAM selective for M4 mAChRs over a panel of 59 receptors ion channels transporters and enzymes at 10 UM selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s 12.3 4798 >10000 >10000 and >10000 nM respectively) inhibits amphetamine-induced locomotor activity in mice and prepulse inhibition deficits in rats at 3.2 mg/kg
Cayman Chemical aLInolenIc ACD methyl STR
An agonist of a7 nAChRs selective for a7 nAChRs over a4B2- a4B4- a3B2- or a3B4 subunit-containing nAChRs and 5-HT3 (EC50s 0.03 >100 >50 >100 >100 and 11 UM respectively in calcium mobilization assays) prevents decreases in the number of retinal ganglion cells in a rat model of glaucoma when applied topically improves sensorimotor deficits and brain edema in a mouse model of intracerebral hemorrhage increases the time spent with the novel object in the novel object recognition test and reverses amphetamine-induced auditory gating deficits in rats at 1 mg/kg reduces food intake and body weight in rats
Cayman Chemical 5 6dehydro ArachIdonIc ACD
This assay kit provides the convenience of an all-inclusive cell-based reporter assay system for FGFR4 paracrine FGF signaling. In addition to Reporter Cells included are an optimized culture medium for use in reviving the cryopreserved cells a culture medium supplemented with heparin for use in preparing test sample treatments the physiological paracrine activator FGF-2 (FGF-Basic) Luciferase Detection Reagents and a cell culture-ready assay plate.
Cayman Chemical DotrIacontnoIc ACD methyl100mg
An orally bioavailable broad-spectrum triazole antifungal agent completely inhibits growth of T. rubrum M. audouini M. canis and T. verrucosum as well as some C. albicans and A. fumigatus strains and other fungi (100 g/ml) bacteriostatic against E. coli P. aeruginosa S. aureus and S. pyogenes (100 g/ml) eliminates vaginal C. albicans candidiasis infection in 97 of rats (1 topical) eliminates vaginal C. albicans candidiasis infection in 50 of rats (10 mg/kg oral) decreases synthesis of 14a-desmethyl sterols and increases synthesis of methylated sterols in C. albicans (IC50 3 nM)
Cayman Chemical 3 3DIthIodIpropIonIc ACD d
An inhibitor of MMP-9 zymogen activation (IC50 440 nM) selective for MMP-9 over MMP-1 MMP-2 and MMP-3 zymogen activation at 10 M inhibits invasion of HT-1080 cells in a MatrigelTM assay (IC50 1 M) reduces disease severity in a mouse model of EAE at 10 and 30 mg/kg twice per day
Cayman Chemical 2Hydroxy Faty ACD Methyl10mg
An adenosine A2B receptor antagonist (Ki 53.4 nM) selective for A2B over A1 and A2A receptors which have Ki values of 2200 and 24000 nM respectively selective for A2B over the A3 receptor which is inhibited only 14 at a concentration of 10 UM pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical DeuTRated ArachIdonIc ACD O
A selective inhibitor of IKK2 (IC50 30 nM) suppresses constitutively activated NF-KB and induces apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma
Cayman Chemical 13 ZDocosenoIc ACD methyl
The main component (80 ) of ivermectin binds to glutamate-gated chloride channels inducing irreversible channel opening ivermectin inhibits replication of SARS-CoV-2 in Vero/hSLAM cells
Cayman Chemical NonadecnoIc ACD methyl Ste
A potent activator of PKA (Ki 30 nM) that is selective for PKA over PKG (Ki 10 UM) resistant to degradation by cyclic nucleotide phosphodiesterases displays good cell permeability and prevents the aggregation of platelets stimulated with thrombin
Cayman Chemical GlycoursodeoxycholIc ACD 500mg
A P-gp inhibitor inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 0 05 UM) inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s 73 and 9 3 UM respectively) enhances growth inhibition of MCF-7/ADR breast cancer cells at 2 or 20 UM when used in combination with doxorubicin in vitro but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 UM
Cayman Chemical 11 ZVaccenIc ACD methyl S
A multiple kinase inhibitor blocking Met Tie2 VEGF2 TrkA TrkB and TrkC with IC50 values of 2 7 8 0 9 2 0 85 4 6 and 0 83 nM respectively orally bioavailable and penetrates the blood brain barrier suppressing the growth of subcutaneous and intracerebroventricular xenograft tumors in mice
Cayman Chemical GlycoursodeoxycholIc ACD Max
Immunogen Peptide from the C-terminal region of human PLCB2 Host Rabbit Species Reactivity ( ) Human Non-human Primate Applications IHC IF MW 135 kDa