Custom Peptides
Cayman Chemical HypocrelIn B 10mg
A fungal metabolite; decreases the viability of, and induces apoptosis in, MDA-MB-231 breast cancer cells when used in the presence of ultrasound exposure; increases the production of ROS in MDA-MB-231 cells at 2.5 µM with concomitant ultrasound exposure; active against MRSA at 20 µM in combination with ultrasound sonication
Cayman Chemical L L-DItyrosIn 10mg
An amino acid conjugate; cross-links of it can form between fibrinogen molecules in the presence of hematin and plasma-generated hydrogen peroxide under non-thermal plasma exposure; cross-links of it can form between human amylin peptides in the presence of copper (II) ions and hydrogen peroxide
Cayman Chemical MagaInIn 1trIfluoroacetAT 10mg
An antimicrobial cationic peptide; reduces germination percentage and mean tube elongation in kiwi fruit pollen (EC50s = 14 and 15.8 µM, respectively); decreases viral replication in Vero cells infected with HSV-1 or HSV-2 (EC50s = 36.59 and 33.2 µM, respectively) without affecting cell viability (CC50 = >100 µM); induces apoptosis in HL-60 cells at 10 and 50 µM and hemolysis in isolated human erythrocytes at 50 µM; induces DNA fragmentation in HL-60 cells in a reporter assay at 10 and 50 µM
Cayman Chemical -5 7-DImethyltocol 10mg
A form of tocopherol; has similar antioxidant activity to α-tocol, but lower activity than γ-tocol; increases microviscosity of PC rat liver liposomes by 70.6% when used at a molar ratio of 0.2 to PC; has been used as an internal standard for the quantification of tocols, tocopherols, and tocopheryl quinones by HPLC
Cayman Chemical Clevdpn 10mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)
Cayman Chemical MethylprotodIoscIn 10mg
A steroidal saponin with diverse biological activities; suppresses EGF- or PMA-induced MUC5AC mucin production in H292 cells at 1 µM; inhibits the proliferation of HeLa cervical cancer cells (IC50 = 18.31 µM); induces production of ROS, apoptosis, and cell cycle arrest at the G2/M phase in HeLa cells; decreases bone loss and prevents decreases in bone mineral content and bone mineral density in a mouse model of ovariectomy-induced osteoporosis at 50 mg/kg
Cayman Chemical MIsonIdazole 10mg
A nitroimidazole with radiosensitizing and antineoplastic properties; metabolites accumulate in hypoxic cells and can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells; used in the imaging of hypoxic regions in tumors and in the cardiovascular system
Cayman Chemical EIcosapentaenoyl SRotonIn 10mg
A hybrid molecule patterned after arachidonoyl serotonin; the biological effects of eicosapentaenoyl serotonin are unknown
Cayman Chemical ZeaxnthIn DIpalmItate 10mg
A beta-acid active against B subtilis and S aureus (MICs 1 and 1 2 Ug/ml respectively) and T b brucei and L m mexicana (IC50s 0 9 and 4 7 Ug/ml respectively) scavenges DPPH radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s 25 and 39 UM respectively) reduces proliferation cell migration and capillary tube formation in HUVECs at 2 5 to 50 Ug/ml lupulone (40 Ug/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells
Cayman Chemical LY456236hydrochlorIde 10mg
An antagonist of mGluR1 (IC50 = 140 nM); reduces the growth of PC-9 cells and PC-9-AMG cells in MGS co-culture but not in monoculture; reduces MGS co-culture-induced increases in EGFR levels in PC-9-AMG cells; reduces tumor growth in a PC-9-AMG mouse model of brain metastasis at 50 mg/kg per day; inhibits seizures in a variety of seizure models, including inhibition of audiogenic clonic-tonic seizures in mice (ED50 = 35 mg/kg); reduces second-phase, but not first-phase, formalin-induced hyperalgesia at 30 and 100 mg/kg
Cayman Chemical 3-O-methyl-L-DOPAhydrate 10mg
An active metabolite of L-DOPA; inhibits L-DOPA-induced neuroprotection in rat primary mesencephalic dopaminergic neurons at 10 and 100 µM
Cayman Chemical 2Acetyl5tetrahydroxybutyl 10mg
An inhibitor of S1P lyase in vivo; not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation; reversibly increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs in mice at 50 UG/ml in drinking water
Cayman Chemical EnalaprIlathydrate 10mg
The active metabolite of the ACE inhibitor, enalapril; inhibits ACE activity with an IC50 value of 5.8 nM in vitro