Custom Peptides
Cayman Chemical SImvastatIn Hydroxy ACDam 10mg
An inhibitor of HMG-CoA reductase (Ki = 0.12 nM); an active metabolite of simvastatin
Cayman Chemical 2ArachIdonyl GlycRol ethR 10mg
A potent and selective agonist of CB1 and GPR55 (EC50s = 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively); binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay); displays the typical tetrad of CB activities in mice; more chemically stable than 2-AG with an endogenous half-life of hours rather than minutes; 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses; reduces intraocular pressure in rabbits when administered at doses exceeding 50 UG per eye; increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets
Cayman Chemical Galoflavn 10mg
An LDH inhibitor (Kis = 5.46 and 15.06 µM, for the A and B isoforms, respectively) that prevents proliferation of many different cancer cells by blocking glycolysis and ATP production
Cayman Chemical SB-216641hydrochlorIde 10mg
A 5-HT1B receptor antagonist; binds to 5-HT1B receptors (Ki = 1 nM); selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1E, and 5-HT1F receptors in radioligand binding assays (Kis = 500, 25, >1,000, and >1,000 nM, respectively); reduces 5-HT-induced inhibition of forskolin-induced cAMP production in CHO cells expressing human 5-HT1B receptors from 1-1,000 nM
Cayman Chemical Dehydro NIfedIpIn 10mg
An active metabolite of nifedipine; formed when nifedipine is metabolized by CYP3A4 and CYP3A5; inhibits glucose uptake in PC-12 cells (IC50 = 130 μM)
Cayman Chemical PDMPhydrochlorIde 10mg
A ceramide analog that contains a mixture of all four possible stereoisomers; inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates and inhibits β-1,4-galactosyltransferase 6, however, the inhibitory activity on both enzymes is attributed to the D-threo enantiomer; enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro
Cayman Chemical DMAPPamonIum salt 10mg
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Cayman Chemical NIsoxetInhydrochlorIde 10mg
A NET inhibitor (Ki = 5.1 nM); selective for NET over DAT and SERT (Kis = 477 and 383 nM, respectively); inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release in mouse brain (EC50s = 2.97 and 0.08 µM, respectively); reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine, in mice at 32 mg/kg; reduces cataplexy in narcoleptic dogs at 0.5 mg/kg i.v.
Cayman Chemical SynthetIc -KavaIn 10mg
A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM (+)-kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 UG/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)
Cayman Chemical FngchInolIn 10mg
An alkaloid; inhibits sheep COX activity and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells (IC50s = 129 and 3.7 µM, respectively); reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons at 1 and 10 µM; decreases proliferation of PC3 human prostate cancer cells by 63 and 86% at 20 and 30 µM, respectively; reduces tumor cell growth in a PC3 mouse xenograft model at 5 mg/kg per day for 12 days
Cayman Chemical THYMOPENTIN 10MG
A pentapeptide fragment of thymopoietin; induces prothymocyte differentiation in isolated mouse splenocytes at 0.018-18 µM; increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human PBLs at 1 UG/ml; reduces the number of splenic autologous rosette-forming cells in athymic mice at 0.02-10 mg/kg; adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model
Cayman Chemical GncIclovIrsodIum salt 10mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical AcrIflavIn MIxture 10mg
A mixture of proflavine, acriflavine, side-methylated proflavine, and side-methylated acriflavine
Cayman Chemical S49076hydrochlorIde 10mg
A multi-kinase inhibitor; inhibits c-Met, Axl, Mer, FGFR1, FGFR2, and FGFR3 (IC50s = 1, 7, 2, 18, 17, and 15 nM, respectively); inhibits Axl- and c-Met-mediated Akt phosphorylation in MDA-MB-231 cells (IC50s = 33 and 50s = 50-200 nM); reduces mean tumor volume in GTL-16 and U87MG mouse xenograft models from 6.25-50 mg/kg
