Custom Peptides
Cayman Chemical Caspofungin (acetate), Purity: ≥98%, CAS: 179463-17-3, 10 mg
An echinocandin antifungal; active against 3,959 Candida clinical isolates (MIC90 = 1 µg/ml), including isolates resistant to fluconazole or itraconazole, as well as 38 Aspergillus clinical isolates, including A. flavus, A. niger, A. terreus, and A. fumigatus (MICs = 50 = 0.6 nM in C. albicans membrane preparations); increases survival in mouse models of disseminated candidiasis or aspergillosis
Cayman Chemical trans-Clovamide, Purity: ≥98%, CAS: 53755-02-5, 10 mg
A naturally occurring caffeoyl conjugate with antioxidant and antiradical properties; demonstrates neuroprotective effects (EC50s = 0.9-3.7 µM) in several in vitro models of neuronal death
Cayman Chemical (2R)-Octyl-α-hydroxyglutarate, Purity: ≥95%, CAS: 1391194-67-4, 10 mg
A cell-permeable derivative of the D-isomer of 2-HG; used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells
Cayman Chemical Pinostilbene, Purity: ≥98%, CAS: 42438-89-1, 10 mg
A stable, monomethoxylated resveratrol derivative that at 0.1-10 μM reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-OHDA and scavenges DPPH radicals (IC50 = 47.1 μM)
Cayman Chemical Anacardic Acid monoene, Purity: ≥95%, CAS: 22910-60-7, 10 mg
A 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position; inhibits SUMOylation in vitro (IC50 = 3 µM) and in cells without affecting protein ubiquitination; directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate
Cayman Chemical 4-tert-Octylphenol diethoxylate, Purity: ≥98%, CAS: 2315-61-9, 10 mg
A degradation product of the surfactant, Triton X that produces weak estrogenic effects in animal and human research studies
Cayman Chemical Necrox-5 (methanesulfonate), Purity: ≥85%, CAS: 1383718-29-3, 10 mg
A cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity; localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibited ~50% cell death in H9C2 cells exposed to 400 μM t-BHP)
Cayman Chemical Phosphoramidon (sodium salt), Purity: ≥98%, CAS: 164204-38-0, 10 mg
A natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes; also a weak inhibitor of the related zinc metalloprotease ECE (Ki = 3.5 µM); has little or no effect on a variety of other proteases
Cayman Chemical p-nitro-Pifithrin-α, Purity: ≥95%, CAS: 389850-21-9, 10 mg
A cell-permeable analog of pifithrin-α that blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α; suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet
Cayman Chemical ON-01910 (sodium salt), Purity: ≥98%, CAS: 1225497-78-8, 10 mg
A potent, non-ATP-competitive inhibitor of Plk1 (IC50 = 9 nM); induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM); active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents
Cayman Chemical 5-(N-ethyl-N-isopropyl)-Amiloride, Purity: ≥98%, CAS: 1154-25-2, 10 mg
A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively; less effectively inhibits NHE4 (IC50 ≥10 μM)
Cayman Chemical 17-trifluoromethylphenyl trinor Prostaglandin F2α, Purity: ≥98%, CAS: 221246-34-0, 10 mg
A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.{9668} 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost.
Cayman Chemical 8-bromo Cyclic GMP (sodium salt), Purity: ≥98%, CAS: 51116-01-9, 10 mg
A cell-permeable analog of cGMP that preferentially activates cGMP-dependent protein kinase; 1 µM-0.1 mM inhibits acetylcholine-induced increases in intracellular calcium concentrations
Cayman Chemical Prostaglandin F2α, Purity: ≥98%, CAS: 551-11-1, 10 mg
A widely distributed primary PG occuring in many species; causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity
Cayman Chemical Zaltoprofen, Purity: ≥98%, CAS: 74711-43-6, 10 mg
An NSAID that displays slight preferential inhibition for COX-2 (IC50s = 1.3 and 0.34 μM for COX-1 and COX-2, respectively); also inhibits bradykinin-induced nociceptive responses by blocking the activation of PKC