Custom Peptides
Cayman Chemical OxyberberIn 10mg
An alkaloid and metabolite of berberine with diverse biological activities; reduces viability of SW480 cells at 1-200 UG/ml; increases the ratio of phosphorylated to unphosphorylated PI3K, Akt, and GSK-3β in isolated rat pancreatic tissue at 50 and 100 mg/kg; reduces rat blood glucose levels in an oral glucose tolerance test in a model of STZ-induced diabetes at 50 and 100 mg/kg; reduces inflammation and hepatosteatosis in a rat model of high-fat diet-induced NAFLD
Cayman Chemical Aldosteron 21sulfATsodIu 10mg
A metabolite of aldosterone; has weak mineralocorticoid activity that is <1% that of aldosterone in rats at 10-100 UG
Cayman Chemical KevetrInhydrochlorIde 10mg
An activator of p53; increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines; decreases cell viability in a panel of cancer cell lines (mean IC50 = 0.49 μM); reduces tumor growth in various mouse xenograft models at 200 mg/kg
Cayman Chemical Elemonic ACD 10mg
A triterpene with anticancer activity; inhibits growth of NSCLC A549 cells (IC50 = 6.92 µM) in vitro; induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner; inhibits phosphorylation of p42/44, MAPK/JNK, and p38 in vitro; induces ROS production and COX-2 expression in vitro; inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro
Cayman Chemical GalactInolhydrate 10mg
An α-galactoside of inositol that serves as a galactosyl donor in the transglycosidase-catalyzed biosynthesis of the raffinose family; generated from myo-inositol and uridine diphosphate galactose in a galactosyltransferase-catalyzed reaction
Cayman Chemical GBR 12935hydrochlorIde 10mg
An inhibitor of dopamine uptake; binds to the dopamine transporter (Kd = 27.2 nM); selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively); it increases locomotor activity in mice at 10 mg/kg; induces gnawing in mice (ED50 = 17.1 mg/kg)
Cayman Chemical AcLEHDAFCtrIfluoroACTAte 10mg
A fluorogenic substrate that can be cleaved by caspase-4, -5, and -9
Cayman Chemical N3oxotetradecnoylLHomos 10mg
A small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria; appears later than shorter acyl chain AHLs in developing biofilms; stimulates the production of putisolvin, which in turn, inhibits biofilm formation
Cayman Chemical 2-AcetylacteosIde 10mg
A phenylethanoid glycoside; selectively inhibits aldose reductase over maltase and sucrase (IC50s = 0.071, >300, and 277 µM, respectively, for the rat enzymes); scavenges superoxide radicals in a cell-free assay and inhibits AAPH-induced hemolysis in isolated rat red blood cells; decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1, 1, and 10 µM; protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 = 4.8 UG/ml); prevents decreases in bone strength in ovariectomized mice from 10-40 mg/kg
Cayman Chemical QuercetIn 3ODGlucose7O 10mg
A flavonoid glycoside with lipid-lowering activity; reduces sodium oleate-induced increases in triglyceride levels in HepG2 cells at 30 µM
Cayman Chemical BrequInarsodIum salt 10mg
A DHODH inhibitor (IC50 = ~20 nM); selective for DHODH over a panel of greater than 400 kinases at 100 nM; induces differentiation of ER-HoxA9, U937, and THP-1 cells in vitro (EC50s = ~1 µM); induces differentiation of tumor cells and reduces tumor growth in a THP-1 mouse xenograft model at 15 mg/kg three times daily or 5 mg/kg per day; induces differentiation of bone marrow leukemic cells and increases survival In a retroviral transduction mouse model of HoxA9 + Meis1 AML
Cayman Chemical nlumbo nucIfera RemerIn 10mg
An aporphine alkaloid with diverse biological activities; selectively binds to the 5-HT2A receptor over 5-HT1A and dopamine D1 and D2 receptors (Kis = 0.0621, 1.17, 1.4, and 22.6 µM, respectively); active against C. albicans as well as chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 4.5, 0.4, and 0.2 UG/ml, respectively); enhances vinblastine-induced cytotoxicity in multidrug-resistant KB-V1 cells; improves survival in a mouse model of MRSA-induced sepsis at 20 mg/kg
Cayman Chemical RVG PeptIDtrIfluoROCTAte 10mg
A peptide nAChR antagonist (IC50 = 2.5 µM); LNPs conjugated to RVG peptide selectively traffic to the brain over the lungs and liver in rats; LNPs conjugated to RVG peptide and encapsulating DFO reduce iron levels in the striatum and substantia nigra, as well as decrease levels of ROS and MDA and increase levels of SOD in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease; RVG-containing and DFO-encapsulating LNPs increase the latency to fall in the rotarod test in the same model of MPTP-induced Parkinson's disease
Cayman Chemical SemaglutIde MaIn ChaIn937 10mg
A peptide starting material in the synthesis of semaglutide