Custom Peptides
Custom Peptides
Cayman Chemical chartreusIs A23187 10mg
A lipophilic analog of 17-trifluoromethylphenyl trinor PGF2a
Cayman Chemical 4-bromo A23187 10mg
A natural acyldepsipeptide that is effective against Gram-positive bacteria including penicillin-resistant S aureus is also effective against many strains of anaerobic bacteria
Cayman Chemical BGJ398phosphate 10mg
A prenylated coumarin with anti-inflammatory and neuroprotective activities inhibits TPA- and A23187-induced histamine release from HMC-1 cells at 10 UM protects against glutamate-induced cytotoxicity in primary rat cortical cells at 0.1-10 UM
Cayman Chemical RS 25344hydrochlorIde 10mg
An NSAID inhibits PGE2 and LTC4 production in A23187-stimulated isolated mouse peritoneal macrophages at 100 UM inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes at 25 and 50 Ug/ml induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner at 10 UM reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice
Cayman Chemical NordeoxycholIc AcId 10mg
An anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation increases apoptosis and inhibits proliferation of NHKs at 2 5 M decreases the mitochondrial membrane potential increases cytochrome c release and induces perinuclear mitochondrial clustering in NHKs at 5 M decreasesBdefensin-2 and S100A9 expression and increases IL-6 and IL-8 expression in IL-17A- and IL-22-stimulated NHKs at 0 25 M inhibits A23187-stimulated LTB4 production from human neutrophils (IC50 7 M) induces hair regrowth in a DEBR model of alopecia areata
Cayman Chemical TolebrutInIb 10mg
A dual inhibitor of COX and 5-LO (IC50s 2.84 and 0.15 UM respectively in RBL-1 cell lysates) inhibits the activity of 12- but not 15- LO (IC50s 4.45 and 146.6 UM for the human platelet and rabbit reticulocyte enzymes respectively) reduces A23187-induced TXB2 and LTB4 production in human PBMCs (IC50s 0.01 and 0.07 UM respectively) and decreases epinephrine-induced platelet aggregation in human PRP (IC50 0.045 UM) inhibits paw swelling in a rat model of adjuvant-induced arthritis (ED50 3.5 mg/kg)
Cayman Chemical MerafloxacIn 10mg
A dual inhibitor of COX and 5-LO (IC50s 2.84 and 0.15 UM respectively in RBL-1 cell lysates) inhibits the activity of 12- but not 15- LO (IC50s 4.45 and 146.6 UM for the human platelet and rabbit reticulocyte enzymes respectively) reduces A23187-induced TXB2 and LTB4 production in human PBMCs (IC50s 0.01 and 0.07 UM respectively) and decreases epinephrine-induced platelet aggregation in human PRP (IC50 0.045 UM) inhibits paw swelling in a rat model of adjuvant-induced arthritis (ED50 3.5 mg/kg)
Cayman Chemical JWH 018 5hydroxyIndl meta 10mg
A histamine H1 receptor antagonist (Ki 15 nM) selective for the histamine H1 receptor over mAChRs (Ki 263 nM) but also inhibits 5-HT2 (Ki 7 nM) inhibits histamine release induced by an anti-IgE antibody in isolated human lung fragments (IC50 4.5 nM) inhibits A23187-induced degranulation of RBL-2H3 mast cells inhibits LPS-induced NO production in RAW 264.7 cells at 50 UM and fMLP- or PMA-induced superoxide production in isolated rat neutrophils reduces histamine-induced vascular permeability in mice (ED50 2.9 mg/kg)
Cayman Chemical JWH 018 7hydroxyIndl meta 10mg
A histamine H1 receptor antagonist (Ki 15 nM) selective for the histamine H1 receptor over mAChRs (Ki 263 nM) but also inhibits 5-HT2 (Ki 7 nM) inhibits histamine release induced by an anti-IgE antibody in isolated human lung fragments (IC50 4.5 nM) inhibits A23187-induced degranulation of RBL-2H3 mast cells inhibits LPS-induced NO production in RAW 264.7 cells at 50 UM and fMLP- or PMA-induced superoxide production in isolated rat neutrophils reduces histamine-induced vascular permeability in mice (ED50 2.9 mg/kg)
Cayman Chemical Cheldonn 10mg
An NSAID and COX inhibitor (IC50s 3 and 9.3 UM for human COX-1 and COX-2 respectively) inhibits TNF-a-induced increases in COX-2 levels and NF-KB activation in HT-29 colon cancer cells in a concentration-dependent manner inhibits fMLP- or A23187-induced calcium influx in PMN (IC50s 29 and 14 UM respectively) activates various ion channels including TRPC6 and KCa1.1 inhibits various ion channels including TRPC3 and CFTR reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae at 20 mg/kg
Cayman Chemical JWH 018 6hydroxyIndl meta 10mg
A histamine H1 receptor antagonist (Ki 15 nM) selective for the histamine H1 receptor over mAChRs (Ki 263 nM) but also inhibits 5-HT2 (Ki 7 nM) inhibits histamine release induced by an anti-IgE antibody in isolated human lung fragments (IC50 4.5 nM) inhibits A23187-induced degranulation of RBL-2H3 mast cells inhibits LPS-induced NO production in RAW 264.7 cells at 50 UM and fMLP- or PMA-induced superoxide production in isolated rat neutrophils reduces histamine-induced vascular permeability in mice (ED50 2.9 mg/kg)
Cayman Chemical JWH 018 4hydroxyIndl meta 10mg
A histamine H1 receptor antagonist (Ki 15 nM) selective for the histamine H1 receptor over mAChRs (Ki 263 nM) but also inhibits 5-HT2 (Ki 7 nM) inhibits histamine release induced by an anti-IgE antibody in isolated human lung fragments (IC50 4.5 nM) inhibits A23187-induced degranulation of RBL-2H3 mast cells inhibits LPS-induced NO production in RAW 264.7 cells at 50 UM and fMLP- or PMA-induced superoxide production in isolated rat neutrophils reduces histamine-induced vascular permeability in mice (ED50 2.9 mg/kg)
Cayman Chemical mK1trIfluoroacetate salt 10mg
A prenylated flavonoid with diverse biological activities inhibits UGT1A6 UGT1A7 and UGT1A8 (IC50s 4 23 0 98 and 3 M respectively) inhibits CYP3A4 CYP1A2 CYP2C9 and CYP2E1 (IC50s 2 13 1 27 3 18 and 9 28 M respectively) inhibits A23187- and PMA-induced histamine and LTC4 production in mouse MC/9 mast cells at 4 M inhibits the growth of MCF-7 MDA MB 231 and MDA MB 453 breast cancer cells (IC50s 13 53 10 84 and 11 99 M respectively) decreases colonic tissue damage TGF-B1 levels and MMP-2 and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis at 12 5 mg/kg per day