Bioactive Small Molecules
TARGETMOL CHEMICALS INC CB2R PAM 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTP(gamma)S binding to CB2 receptors but has no effect in the absence of agonists. ...CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain. purity: 98%
Apexbio Technology LLC Plerixafor 8HCl (AMD3100 8HCl), 50mg. Cas: 155148-31-5 MFCD: MFCD04974488. CXCR4 antagonist
Plerixafor 8HCl (AMD3100 8HCl) is a potent and selective antagonist of CXCL12-mediated chemotaxis and G-protein coupled chemokine receptor (CXCR4) with IC50 values of 5.7 and 44 nM, respectively [1]. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY ValrubIcIn 5mg
A semisynthetic anthracycline antitumor antibiotic; inhibits the growth of human bladder tumor cell lines (LD50s = 0.05-11.2 μM); more active against cells in the plateau growth phase than in the log growth phase (LD70s = 2.5 and 12.1 μM, respectively for CUB-2 cells); increases survival in mice with murine P388 and L1210 leukemias; reduces epidermal thickness and normalizes epidermal morphology in a mouse psoriasis xenograft transplantation model
Cayman Chemical ANTIBODY P22077 10mg
A dual inhibitor of USP7 and USP47 (EC50s = 8.01 and 8.74 µM, respectively); selective for USP7 and USP47 over other USPs and proteases with EC50 values greater than 50 µM; induces the accumulation of polyubiquitinated proteins in HEK293 cells when used at a concentration of 25 µM; amplifies the cytotoxicity and p53-mediated apoptosis of doxorubicin of doxorubicin and etoposide in neuroblastoma cells when used at concentrations of 10 and 20 µM; inhibits tumor growth in neuroblastoma mouse xenograft models when administered at a dose of 20 mg/kg per day
Medchemexpress LLC Diamfenetide | 36141-82-9 | 99.7% | 250 MG
Diamfenetide is a research reagent and analytical standard used to study Fasciola hepatica infections in vitro; it induces irreversible paralysis in immature and adult parasites.
- Used in vitro to study Fasciola hepatica infections.
- Induces irreversible paralysis of immature and adult parasites.
- Provided as a high-purity analytical standard for research applications.
- Molecular formula C20H24N2O5, molecular weight 372.41 g/mol.
- Commonly supplied in small-quantity packs suitable for laboratory use.
STEMCELL Technologies (S)-MG132, Size: 10 mg
(S)-MG132 is a reversible, cell-permeable inhibitor of proteasome activity (IC₅₀ = 100 nM; Kisselev & Goldberg) and calpain (IC₅₀ = 1.2 µM; Tsubuki et al.). The ubiquitin-proteasome pathway selectively degrades intracellular proteins, thereby clearing damaged or misfolded proteins, and regulating the availability of key proteins involved in the control of inflammatory processes and cell cycle regulation. (S)-MG132 suppresses NF-κB activation by preventing IκB degradation (IC₅₀ = 3 µM; Arlt et al., Palombella et al., Ortiz-Lazareno et al.).CANCER RESEARCH· Blocks apoptosis triggered by DNA damage in HeLa cells (Zhang et al.).· Inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis (Arlt et al.).· Cytotoxic effects on a variety of human cancer cell lines (Banerjee & Liefshitz).· Inhibits growth of mouse melanoma (B16) and human ocular melanoma (IPC227F) cell lines (Vivier et al.).
Selleck Chemical LLC Deferoxamine mesylate 25mg 138-14-7 Desferrioxamine B
Deferoxamine mesylate (Desferrioxamine B) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1? expression and improves HIF-1? transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (A?) deposition and induces autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical ANTIBODY CP 673 451 5mg
A selective inhibitor of PDGFRβ and PDGFRα kinases (IC50s = 1 and 10 nM, respectively); antiangiogenic and antitumor activity in several in vivo tumor models
Cayman Chemical ANTIBODY JAK3-IN-2 25mg
A JAK3 inhibitor (Ki = 0.07 nM); selective for JAK3 over JAK1 and JAK2 (Kis = 320 and 740 nM, respectively); inhibits IL-2-induced STAT5 gene expression in a reporter assay (IC50 = 70 nM); reduces paw swelling and ankle bone loss in a rat model of collagen-induced arthritis at 100, 300, and 600 mg/kg
Cayman Chemical ANTIBODY DTPA 25g
A cell-impermeable metal chelating agent; chelates copper, iron, zinc, and manganese, as well as calcium, magnesium, and plutonium; has been used as a metal chelating agent in the study of ferroptosis; reduces the skeletal plutonium burden and incidence of bone tumors, as well as increases survival in a mouse model of intravenous plutonium exposure at 500 mg/kg
Medchemexpress LLC HY-B0031 500mg Medchemexpress, Quetiapine (hemifumarate) CAS:111974-72-2 Purity:>98%
Medchemexpress, HY-B0031 500mg Quetiapine (hemifumarate) CAS:111974-72-2 Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Urea, N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]- | 708275-58-5 | 99.2% | 484.18 | 25 MG
JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist with a pKi of 8.3, exhibiting 600-fold selectivity for OX2R over OX1R. It is intended for research use only.
- Potent and selective orexin 2 receptor (OX2R) antagonist
- 600-fold selective for OX2R over OX1R
- Decreases latency for persistent sleep and increases nonrapid eye movement and rapid eye movement sleep time
- Blocks ethanol self-administration, place preference, and reinstatement
- Suitable for oral and intraperitoneal injection protocols
Cayman Chemical NorfluoxetInhydrochlorIde 5mg
An active metabolite of fluoxetine; inhibits 5-HT uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM); has been found in the tissues of fish exposed to wastewater effluent