Bioactive Small Molecules
Cayman Chemical ANTIBODY ML-141 1mg
A noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac; also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 µM)
Cayman Chemical TeIcoplnIn A2-5 5mg
A non-polar glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria
Cayman Chemical ANTIBODY GSK2193874 5mg
A potent, selective antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively; effective in vivo, as it resolves pulmonary edema resulting from myocardial infarction in mice
Cayman Chemical ANTIBODY LT175 5mg
A dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC50s = 0.22, 0.26, and 0.48 µM for hPPARα, mPPARα, and hPPARγ, respectively); improves glucose homeostasis in diet-induced insulin resistant mice
Cayman Chemical ANTIBODY C-6 NBD 1g
A derivative of NBD modified with a hexanoic acid tail, which provides a reactive carboxylic acid site; used to synthesize a variety of fluorescently tagged compounds for research purposes
Cayman Chemical ANTIBODY GSK137647A 5mg
A selective agonist of GPR120 (EC50s = 0.5, 0.63, and 0.79 µM for human, mouse, and rat receptors, respectively); dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions
Cayman Chemical ANTIBODY CAY10580 5mg
An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2; selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively); stimulates cAMP formation in excised mouse ovaries
Cayman Chemical ANTIBODY AZ 7371 5mg
A non-covalent inhibitor of bacterial DprE1; inhibits wild-type M. smegmatis DprE1 and DprE1C394G (IC50 = 0.01 µM for both) but not DprE1Y321H (IC50 = >10 µM); active against wild-type M. tuberculosis DprE1 (MIC = 1.56 µM) and DprE1C387S or DprE1C387G (MICs = 0.39 and 0.78 µM, respectively) but not DprE1Y314H (MIC = >200 µM); selective for these targets over Gram-positive and Gram-negative bacteria but does inhibit phosphodiesterase 6 (PDE6; IC50 = 4 µM)
Cayman Chemical ANTIBODY ErastIn 5mg
A ferroptosis inducer; induces ferroptotic cell death in vitro, an effect that can be blocked by ferroptosis inhibitors; inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells at 5 µM; inhibits glutamate release via the cystine-glutamate transporter in an enzyme-coupled fluorescence assay (EC50 = 1.2 µM); selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 UG/ml)
Cayman Chemical ANTIBODY ElacrIdar 50mg
A dual inhibitor of MRP-1 and BCRP; maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM; effective against both human BCRP and the mouse homolog, Bcrp1
Cayman Chemical ANTIBODY CBR-5884 25mg
An inhibitor of PHGDH, inhibiting serine synthesis from 3-PG in cells (IC50 = 33 µM); inhibits the proliferation of cancer cells by blocking de novo serine synthesis
Cayman Chemical TamoxIfen N-oxIde 10mg
A metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases
Cayman Chemical ANTIBODY DIflunIsal 10g
An NSAID that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively)
Cayman Chemical ANTIBODY SpautIn-1 10mg
An autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM); promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively)