Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,756 – 4,770 of 60,549 results

4,756

Cell Signaling Technology CHIR-99021, GSK-3 Inhibitor, Lyophilized Powder, 5 mg

CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) and GSK-3α with IC₅₀ values of 6.7 and 10 nM, respectively. By demonstrating >500-fold selectivity for GSK-3 over 20 other protein kinases, this compound is valuable for researching pathways involved in type 1 and type 2 diabetes, where it has been shown to increase beta cell replication in isolated rat islets.

Potent inhibition of GSK-3β and GSK-3α
High selectivity (>500-fold) for GSK-3
Supports research into beta cell replication
Supplied as a lyophilized powder
Easy reconstitution in DMSO for a 10 mM stock

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4,757

Cell Signaling Technology Hydroxychloroquine Sulfate, >98% Purity, 50 mg

Hydroxychloroquine Sulfate is a 4-aminoquinoline derivative of quinine that acts as an anti-malaria drug and immunomodulatory agent. It is utilized in studies of rheumatoid arthritis, systemic lupus erythematosus, and various rheumatic diseases due to its ability to inhibit lysosome and autophagosome functions, interfere with cytokine production, and disrupt cGAS/dsDNA complexes to inhibit IFN-β production. The compound also demonstrates antiviral and anti-inflammatory effects, including inhibition of SARS-CoV-2 infection in vitro.

Supplied as a lyophilized powder
Inhibits IFN-β production with an IC₅₀ of 25 μM
Modulates metabolic, cardiovascular, antithrombotic, and antineoplastic pathways
For a 10 mM stock, reconstitute 5 mg of powder in 1.15 mL of water

Pricing & Availability

4,758

Cell Signaling Technology U-18666A, Cholesterol Transport Inhibitor, 5 mg

U-18666A is a cell-permeable small molecule that functions as a potent inhibitor of intracellular cholesterol transport. By blocking low-density lipoprotein (LDL)-derived cholesterol trafficking, this compound prevents cholesterol esterification and suppresses LDL receptor activity. It is widely utilized in research to simulate intracellular cholesterol accumulation, providing a valuable tool for investigating the pathogenesis of neurological disorders, such as Alzheimer™ disease and Niemann-Pick disease type C, as well as atherosclerosis and viral infection mechanisms.

Inhibits LDL-derived cholesterol transport and esterification
Suppresses LDL receptor activities
Useful for studying intracellular cholesterol accumulation and neurodegenerative pathologies
Relevant for research on viral entry and replication
Supplied as a lyophilized powder

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4,759

Cell Signaling Technology Poly(I:C) Sodium Salt, Lyophilized, >98% Purity, 25 mg

Poly(I:C) Sodium Salt is a synthetic analog to double-stranded RNA (dsRNA) and a potent activator of Toll-like receptor 3 (TLR3). It plays a significant role in the innate immune response by mimicking viral infection to trigger the activation of transcription factors NF-κB and IRF3. This reagent is intended for research use.

Acts as a potent TLR3 agonist
Supplied as a lyophilized powder
Purity of >98%
Soluble in water at 10 mg/mL with warming
Compatible with use in studies investigating vaccine immunogenicity

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4,760

Medchemexpress LLC Oxyphenbutazone monohydrate | 7081-38-1 | 98.0% | 50 MG

Oxyphenbutazone monohydrate is a metabolite with anti-inflammatory effects. It acts as an orally active non-selective COX inhibitor and can selectively eliminate non-replicating Mycobacterium tuberculosis.

Anti-inflammatory effect.
Orally active.
Non-selective COX inhibitor.
Selectively kills non-replicating Mycobacterium tuberculosis.
Enhances anticancer efficiency in certain cells.
Exhibits reparative effects in hepatocytes.

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4,761

AdipoGen Geodin (5 mg)

Chemical. CAS: 427-63-4. Formula: C17H12Cl2O7. MW: 399.2. Isolated from Penicillium sp. FKI-5002. Plasminogen activator inhibitor (PAI-1). Glucose uptake stimulator.

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4,762

AdipoGen DAF-4T (1 mg)

Chemical. CAS: 212558-80-0. Formula: C20H7O5N3Cl2. MW: 440.19. Fluorescent reference compound for DAF-4 DA (CDX-D0216). Spectral data: lambdaEx=505nm; lambdaEm=530nm.

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4,763

AdipoGen DAF-4T (5 mg)

Chemical. CAS: 212558-80-0. Formula: C20H7O5N3Cl2. MW: 440.19. Fluorescent reference compound for DAF-4 DA (CDX-D0216). Spectral data: lambdaEx=505nm; lambdaEm=530nm.

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4,764

Cayman Chemical HT-2 Toxin, Purity: ≥98%, CAS: 26934-87-2, 5 mg

A mycotoxin and an active metabolite of T-2 toxin; reduces viability of a variety of cancer cells (IC50s = 3.1-23 ng/ml) and HUVECs (IC50 = 56.4 ng/ml); induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos at 10 nM

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4,765

Selleck Chemical LLC Enfortumab vedotin-ejfv-1MG-5

Enfortumab vedotin-ejfv (Padcev) is an antibody-drug conjugate (ADC) composed of an fully human anti-Nectin-4 IgG1 kappa monoclonal antibody (AGS-22C3) conjugated to Monomethyl Auristatin E (MMAE) via a protease-cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl Enfortumab vedotin-ejfv has the potential for use in research of urothelial carcinoma

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4,766

Cayman Chemical Proscaline (hydrochloride), Purity: ≥98%, CAS: 61367-69-9, 5 mg

An analytical reference standard categorized as a phenethylamine; intended for research and forensic applications

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4,767

Medchemexpress LLC MK-4166 5mg | 5mg

MK-4166 is a humanized IgG1 agonist monoclonal antibody targeting GITR MK-4166 enhances the proliferation of both na ve and tumor-infiltrating T lymphocytes[1]

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4,768

Active Motif GSK-J4 (cell permeable)

Active Motif's GSK-J4 is an inhibitor of the histone demethylase JMJD3/UTX. It inhibits demethylation of histone H3K27. GSK-J4 reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF-alpha release). It is a cell permeable, ethyl ester of GSK-J1 (Catalog No. 14068). GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

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4,769

Medchemexpress LLC Antineoplaston A10 | 91531-30-5 | 99.8% | 100 MG

Antineoplaston A10 is an antineoplaston that inhibits the growth of human hepatoma cells by inducing apoptosis. It is for research use only and can be used in the study of liver cancer and breast cancer.

Inhibits the growth of human hepatoma cell lines HepG2 and HLE
Induces apoptosis
Targets Ras
Reduces bcl-2 expression in cytoplasm
Increases nuclear p53 expression

Pricing & Availability

4,770

Medchemexpress LLC 1-Boc-homopiperazine | 112275-50-0 | 99.87% | 200.28 | 50 G

1-Boc-homopiperazine is a drug intermediate used for the synthesis of bacterial FtsZ inhibitors. It is a colorless to light yellow liquid for research use only.

Used for the synthesis of bacterial FtsZ inhibitors
Colorless to light yellow liquid appearance
High purity of 99.87%
Molecular weight of 200.28
Recommended storage at 4°C, protected from light

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Bioactive Small Molecules

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Cell Signaling Technology CHIR-99021, GSK-3 Inhibitor, Lyophilized Powder, 5 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cell Signaling Technology Hydroxychloroquine Sulfate, >98% Purity, 50 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cell Signaling Technology U-18666A, Cholesterol Transport Inhibitor, 5 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cell Signaling Technology Poly(I:C) Sodium Salt, Lyophilized, >98% Purity, 25 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Oxyphenbutazone monohydrate | 7081-38-1 | 98.0% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MK-4166 5mg | 5mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Antineoplaston A10 | 91531-30-5 | 99.8% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-Boc-homopiperazine | 112275-50-0 | 99.87% | 200.28 | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More