Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,801 – 4,815 of 60,549 results

4,801

AdipoGen Cucurbitacin E (1 mg)

Chemical. CAS: 18444-66-1. Formula: C32H44O8. MW: 556.7. Isolated from Cucumis melo L. Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Immunomodulator with anti-inflammatory and anti-tumorigenic properties in a range of cancer cell lines, mediated by its action on the cellular cytoskeleton, on mitotic pathways as well as on cellular autophagy. Shown to induce apoptosis, autophagy and cell cycle arrest at G2/M. Inhibits tumor angiogenesis through Jak-STAT3 signaling pathway, suppresses cell migration and invasion, and inhibits NF-kappaB nuclear translocation. Antioxidant and potential neuroprotective compound with potential neurodegenerative properties.

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4,802

AdipoGen Compound 34 (200 µg)

Chemical. CAS: 564462-36-8. Formula: C31H24F3N3O3. MW: 543.5. Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM).

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4,803

AdipoGen Bisindolylmaleimide II (1 mg)

Chemical. CAS: 137592-45-1. Formula: C27H26N4O2. MW: 438.5. Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA).

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4,804

Medchemexpress LLC HY-N2083 5mg Medchemexpress, Handelin CAS:62687-22-3 Purity:>98%

Medchemexpress, HY-N2083 5mg Handelin CAS:62687-22-3 Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,805

Medchemexpress LLC ARMET/MANF Human H 500ug

Recombinant human mesencephalic astrocyte-derived neurotrophic factor (MANF) supplied lyophilized with an N-terminal His tag. The product corresponds to UniProt P55145 (residues L25-L182), is expressed in E. coli, and is provided at high purity for research applications including studies of neuroprotection, endoplasmic reticulum stress, and cell signaling.

His-tagged for affinity purification and detection.
Expressed in E. coli for efficient production.
Contains residues L25-L182 of the human sequence.
Purity ≥95% as determined by reducing SDS-PAGE.
Do not reconstitute below 100 μg/mL in ddH2O.
Lyophilized for long-term storage; aliquot and freeze for extended stability.
Suitable for in vitro research on neuroprotection and ER stress pathways.

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4,806

Cayman Chemical Tezacaftor, Purity: ≥98%, CAS: 1152311-62-0, 10 mg

An investigational compound that promotes the maturation of Delta F508 mutants of CFTR

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4,807

Cayman Chemical SR 12460, Purity: ≥98%, CAS: 2055101-66-9, 10 mg

An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; inhibits TNF-α-induced NF-κB activation in a reporter assay from 25-150 µM; reduces LPS-induced IL-6 production in RAW 264.7 cells; improves grip strength in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg

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4,808

Cayman Chemical SU 16f, Purity: ≥98%, CAS: 251356-45-3, 5 mg

A potent inhibitor of PDGFRβ (IC50 = 10 nM); inhibits VEGFR2 (IC50 = 140 nM); selectively inhibits PDGF- over VEFG-, FGF-, and EGF-induced cell proliferation (IC50s = 0.11, 10, 10, and 21.9 μM, respectively); accelerates downregulation of fibroblast genes and increases the yield of beating clusters in HFFs treated with 15 compounds to induce a cardiac myocyte-like phenotype

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4,809

Medchemexpress LLC (±)-Vesamicol hydrochloride | 120447-62-3 | 99.8% | 25 MG

(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. It also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively. The pharmacological actions of (±)-Vesamicol are attributed to the inhibition of acetylcholine transport into synaptic vesicles and subsequent quantal release of acetylcholine.

Potent vesicular acetylcholine transport inhibitor
Displays high affinity for σ1 and σ2 receptors
Inhibits acetylcholine transport into synaptic vesicles
Reduces subsequent quantal release of acetylcholine
Increases cytosolic acetylcholine levels in rat brain
Decreases vesicular acetylcholine levels in rat brain (except striatum)

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4,810

Selleck Chemical LLC Sodium L-lactate

Sodium L-lactate is used as a food additive preservative acidity regulator and bulking agent

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4,811

Selleck Chemical LLC GNE-477

GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3K and Kiapp of 21 nM for mTOR

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4,812

Selleck Chemical LLC TLR2-IN-C29 5mg

TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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4,813

Selleck Chemical LLC STING inhibitor C-178 2mg

C-178 is a covalent inhibitor of STING,covalently bind to Cys91. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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4,814

Selleck Chemical LLC TH5487 5mg

TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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4,815

Selleck Chemical LLC GCN2iB 5mg

GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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Bioactive Small Molecules

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Medchemexpress LLC HY-N2083 5mg Medchemexpress, Handelin CAS:62687-22-3 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC ARMET/MANF Human H 500ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (±)-Vesamicol hydrochloride | 120447-62-3 | 99.8% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-N2083 5mg Medchemexpress, Handelin CAS:62687-22-3 Purity:>98%

Medchemexpress LLC ARMET/MANF Human H 500ug

Medchemexpress LLC (±)-Vesamicol hydrochloride | 120447-62-3 | 99.8% | 25 MG