Bioactive Small Molecules
Selleck Chemical LLC Retatrutide P1230-5MG
Retatrutide (LY3437943) acts as a triple agonist peptide of the glucagon receptor (GCGR) glucagon-like peptide-1 receptor (GLP-1R) and glucosedependent insulinotropic polypeptide receptor (GIPR) Retatrutide binds to human GCGR GLP-1R and GIPR with EC50 values of 5 79 0 775 nM and 0 0643 respectively Retatrutide has the potential for use in research on obesity
Cayman Chemical ANTIBODY BIX02189 10mg
A potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively); minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2; blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells
Medchemexpress LLC BMS-986238 | 2919596-13-5 | 99.9% | 2979.52 | C143H224N26O40S | 10 MG
BMS-986238 is a second-generation macrocyclic peptide designed as a potent inhibitor of programmed death-ligand 1 (PD-L1) for preclinical research. It is intended for use in studies of solid tumors and lymphomas and is supplied with supporting product and chemical information for laboratory applications.
- Second-generation macrocyclic peptide scaffold suitable for research.
- Potent PD-L1 inhibitory activity for immuno-oncology studies.
- High reported purity (99.94%) supporting biochemical assays.
- Available in small milligram pack sizes for compound screening.
- Supplied with datasheet including CAS, molecular formula, and molecular weight.
Cayman Chemical RGDtargetd ProapoptotIcpep 5mg
A peptide; contains an integrin-binding cyclic region (CDCRGDCFC) and a region similar to a pro-apoptotic heptadimer sequence (klaklakklaklak), both of which are found in similar peptides
Medchemexpress LLC Tr-PEG2-OH 1g | 105589-77-3 | 1 G
Tr-PEG2-OH is a PEG-based linker used to connect small molecules or payloads in PROTAC and ADC synthesis. It is a non-cleavable, two-unit polyethylene glycol spacer that increases solubility and provides flexible spacing for bioconjugation.
- Used as a PROTAC linker and as a non-cleavable two-unit PEG ADC linker.
- Provides spacing and improves solubility between conjugated moieties.
- White to off-white solid with low water content (~0.31%).
- High HPLC purity reported on COA (99.45% for batch example).
- Available in small pack sizes suitable for research (e.g., 1 G).
Cayman Chemical ANTIBODY M-110 1mg
A Pim-3 kinase inhibitor (IC50 = 0.05 µM); selective for Pim-3 over Pim-1 and Pim-2 (IC50s = 2.5 µM for both); inhibits the growth of DU145 and MIA PaCa-2 cells (IC50s = 0.9 and 3.9 µM, respectively); inhibits IL-6-induced STAT3 phosphorylation in DU145 cells at 10 µM
Cayman Chemical ANTIBODY CyazofamId 100mg
A fungicide; active against several isolates of P. infestans, as well as P. sojae, P. aphanidermatum, P. paddicum, P. sylvaticum, and A. cochlioides (EC50s = 0.008-0.03, 0.2, 0.02, 0.2, 0.2, and 0.2 UG/ml, respectively); selectively inhibits P. spinosum mitochondrial complex III activity over B. cinerea, S. cerevisiae, potato tuber, and rat liver mitochondrial complex III activities at 10 µM; protects against P. brassicae-induced root hair infections in cabbage when applied to dry soil at 10 mg/kg
Cayman Chemical ANTIBODY DIgoxIn 250mg
A Na+/K+-ATPase inhibitor; induces loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular Ca2+ levels, inotropy, and cardiac force; increases activity of mitochondrial ATPase and actomyosin ATPase in rat hearts, which is directly correlated with increased myofibrillar contractile strength; decreases right atrial pressure and increases cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction
Medchemexpress LLC Mazdutide | 2259884-03-0 | 99.9% | 4563.06 | 1 MG
Mazdutide (IBI-362) is a long-acting synthetic oxyntomodulin analog that acts as a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). It stimulates insulin secretion and is utilized in studies concerning obesity and type 2 diabetes.
- Long-acting synthetic oxyntomodulin analog
- Co-agonist of GLP-1R and GCGR
- Binds to human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively)
- Binds to GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively)
- Stimulates insulin secretion from mouse islets (EC50: 5.2 nM)
- Reduces body weight and physical intake in diabetic mice with diet-induced obesity
Selleck Chemical LLC Ropsacitinib S9676-100MG
Ropsacitinib (PF-06826647 Tyk2-IN-8 compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain PF-06826647 (Tyk2-IN-8 compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM respectively PF-06826647 (Tyk2-IN-8 compound 10) is used in the treatment of psoriasis (PSO)
Medchemexpress LLC Tyr3-octreotate | 302794-43-0 | 99.76% | 1049.22 | 1 MG
Tyr3-Octreotate is a somatostatin analog that exhibits high uptake into tumors. It can be labeled with radioactive metal, demonstrating antitumor efficacy. This product can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
Medchemexpress LLC Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp | 1042405-14-0 | 99.5% | 1285.33 | 25 MG
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1), utilized for detecting proteinase 3 (PR3) activity.
- Fluorescence-quenched peptide substrate for human proteinase 3
- Used for detection of proteinase 3 (PR3) activity
- High purity of 99.49%
- Stable for extended periods under recommended storage conditions
- Available in powder or solvent formulations
Medchemexpress LLC Skeletal muscle-targeted peptide MSP | 216763-24-5 | 98.7% | 674.74 | 25 MG
Skeletal muscle-targeted peptide MSP is a 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP). It is capable of targeting viruses through various binding ligands to the muscle and can be utilized for research into diseases affecting the heart and skeletal muscles.
- 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP)
- Capable of targeting viruses through various binding ligands to the muscle
- Utilized for research into diseases affecting the heart and skeletal muscles
Medchemexpress LLC Thiazolo[5,4-f]quinazoline-2-carboximidic acid, 9-[(2-fluoro-4-methoxyphenyl)amino]-, methyl ester | 1425945-60-3 | 98.1% | 383.40 | 25 MG
EHT 1610 is a potent and selective inhibitor of DYRK1A and DYRK1B, demonstrating antileukemia effects by inducing apoptosis and regulating the cell cycle. It targets key signaling pathways, including FOXO1, STAT3, and cyclin D3, to impact cell-cycle progression, mitochondrial ROS, and DNA damage. In vivo, EHT 1610 exhibits antileukemia activity, reducing leukemic burden and improving survival in B-ALL xenograft models. This compound is a light yellow to yellow solid and requires freshly prepared solutions due to its inherent instability.
- Potent DYRK inhibitor (DYRK1A IC50 0.36 nM, DYRK1B IC50 0.59 nM)
- Induces apoptosis in leukemic cells, including resistant ALL
- Regulates cell cycle; inhibits FOXO1, STAT3, cyclin D3 phosphorylation
- In vivo antileukemia activity and survival benefits in B-ALL models
- Light yellow to yellow solid
- Unstable in solutions; requires fresh preparation
Medchemexpress LLC Insulin (cattle) | 11070-73-8 | 98.4% | 5800 | 25 MG
Insulin (cattle) is a two-chain polypeptide hormone produced by the pancreatic β cells. It is commonly used as a growth supplement in cell culturing. In vitro, the α and β chains are joined by two interchain disulfide bonds, and the α chain contains an intrachain disulfide bond. This hormone regulates glucose uptake into muscle and fat cells by recruiting membrane glucose transporter Glut-4 to the cell surface. It has been effectively utilized in cell cultures at concentrations ranging from 1 to 10 μg/mL.
- Two-chain polypeptide hormone
- Produced by pancreatic β cells
- Used as a growth supplement in cell culturing
- Regulates glucose uptake into muscle and fat cells
- Recruits membrane glucose transporter Glut-4 to the cell surface
- Effective for cell culturing at 1 to 10 μg/mL concentration