Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,031 – 6,045 of 60,541 results

6,031

Selleck Chemical LLC DIABZI STING AGONIST 5MG

diABZI STING agonist (Compound 3) 5mg *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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6,032

Cayman Chemical BYL719, Purity: ≥98%, CAS: 1217486-61-7, 50 mg

An inhibitor of PI3Kα (IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively); selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all); reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model at 12.5, 25, and 50 mg/kg; also reduces tumor burden in THP-1 AML and MCF-7 breast cancer mouse xenograft models

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6,033

Cayman Chemical Apilimod, Purity: ≥98%, CAS: 541550-19-0, 5 mg

An inhibitor of PIKfyve (IC50 = 14 nM); is selective for PIKfyve over 10 other lipid kinases and 31 other protein kinases (IC50s = >9.1 µM for all); inhibits the production of IL-12p40 induced by IFN-γ and LPS or R-837 in isolated human PBMCs (IC50s = 2.4 and 3 nM, respectively) and the production of IL-23 induced by IFN-γ and SAC in isolated human PBMCs (IC50 = 10 nM); prevents infection of Vero E6 cells by SARS-CoV-2 (EC50 = 23 nM); reduces cell viability in a panel of B cell non-Hodgkin lymphoma cell lines (mean IC50 = 142 nM); decreases disease severity in a CD4+CD45Rbhigh T cell transfer mouse model of IBD at 10 mg/kg; decreases disease severity in a mouse model of IRBP1-20-induced experimental autoimmune uveoretinitis

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6,034

Cayman Chemical (±)-Epinephrine (hydrochloride), Purity: ≥95%, CAS: 329-63-5, 1 g

A natural neurotransmitter that is activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively); may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression

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6,035

Cayman Chemical CW069, Purity: ≥95%, CAS: 1594094-64-0, 1 mg

An inhibitor of KIFC/HSET (IC50 = 75 µM); increases the number of multipolar spindles in N1E-115 cells with supernumerary centrosomes at 100 and 200 µM; inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 µM, respectively)

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6,036

Aat Bioquest Cal-630 AM (5x50 ug)

Calcium measurement is critical for numerous biological investigations. This catalog is for 5x50 ug.

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6,037

Cayman Chemical 5'-N-Ethylcarboxamidoadenosine (hydrate), Purity: ≥98%, 5 mg

An adenosine receptor agonist (Kis = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A1, A2A, and A3, respectively); potent vasodilator that can inhibit platelet aggregation by increasing cAMP (EC50 = 3.1 µM)

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6,038

Aat Bioquest BAPTA AM UltraPure Grade CAS 126150-97-8 (25 mg)

BAPTA AM is cell-permeable version of BAPTA 12-biso-aminophenoxyethane-NNNN-tetraacetic acid a cell-permeable calcium chelator. This catalog is for 25 mg.

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6,039

Cayman Chemical 8-hydroxy DPAT (hydrobromide), Purity: ≥98%, CAS: 76135-31-4, 5 mg

A 5-HT1A receptor agonist (EC50 = 12 nM in rat hippocampal membranes); enhances the behavioral effects of Δ9-THC in rhesus monkeys in a discriminant stimulus-shock test (0.178 mg/kg, i.v.); reduces baclofen-induced aggression in mice when administered directly to the dorsal raphe nucleus; impairs contextual fear in mice when administered prior to training (0.5 mg/kg, s.c); reduces apnea in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome (50 µg/kg i.p.)

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6,040

Cayman Chemical Dichlorvos-d6, Purity: ≥99% deuterated forms (d1-d6), CAS: 203645-53-8, 5 mg

An internal standard for the quantification of dichlorvos by GC- or LC-MS

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6,041

Cayman Chemical Nordihydrocapsaicin, Purity: ≥98%, CAS: 28789-35-7, 5 mg

A capsaicinoid

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6,042

Cayman Chemical DFHBI 1T, Purity: ≥98%, CAS: 1539318-36-9, 5 mg

A fluorescent probe for RNA; ex/em = 447/501 nm, respectively; fluoresces upon binding to RNA aptamers; has been used to image RNA in live cells

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6,043

Cayman Chemical TRx0237 (mesylate), Purity: ≥95%, CAS: 1236208-20-0, 5 mg

An inhibitor of tau aggregation; inhibits tau-tau binding (IC50 = 238 µM) and tau aggregation in 3T6H cells expressing human tau (EC50 = 0.19 µM); increases hippocampal ACh and synaptophysin levels, as well as increases mitochondrial complex IV activity, decreases tau pathology, and reverses deficits in spatial learning in the L1 transgenic mouse model of Alzheimer’s disease

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6,044

Cayman Chemical ThioGlo1, Purity: ≥95%, CAS: 137350-66-4, 50 mg

A thiol-reactive fluorescent probe; ex/em = 384/513 nm, respectively; reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods; has been used to monitor oxidative stability in beer

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6,045

Cayman Chemical Diapocynin, Purity: ≥98%, CAS: 29799-22-2, 10 mg

An NADPH oxidase inhibitor with anti-inflammatory and antioxidant activities; inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in PMBCs; inhibits ROS production, iPLA2 function, and reduces Ca2+ influx through SOCs and SACs in dystrophic myotubes; reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson's disease

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Bioactive Small Molecules

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