Bioactive Small Molecules
Selleck Chemical LLC CVN293 E4642-1G
CVN293 is a potent selective and brain permeable small-molecule inhibitor of potassium (K ) ion channel KCNK13 with an IC50s of 49 nM and 28 nM for hKCNK13 and mKCNK13 respectively It also inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1 production in LPS-stimulated primary neonatal murine microglia with an IC50 of 24 nM and has potential applications in Alzheimer s disease research
Medchemexpress LLC GM-CSF Huma 2ug | 2ug
GM-CSF R alpha is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 GM-CSF R alpha binds to the cytokine with high specificity and low affinity[1] GM-CSF R alpha binds to GM-CSF and induces cell differentiation[2] GM-CSF R alpha monoclonal antibody decreases GM-CSFR expression on GM-CSF-responsive cells and shows anti-inflammatory activity in rheumatoid arthritis (RA)[3] GM-CSF R alpha Protein Human (HEK293 His) is a recombinant protein with a C-Terminal His label It consists of 298 amino acids (E23-G320) and is produced in HEK293 cells
![Medchemexpress LLC 2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-, dihydrochloride | 99.70% | 573.51 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437391-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-, dihydrochloride | 99.70% | 573.51 | 100 MG
SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM. It is for research use only and not sold to patients. The product is provided as a solid with a light yellow to yellow color. The compound can suppress SPOP activity, leading to an increase in suppression cancer substrate protein PTEN and DUSP7 content in vitro.
- Potent speckle-type POZ protein (SPOP) inhibitor
- IC50 of 3.58 μM
- Suppresses SPOP activity, increasing suppression cancer substrate protein PTEN and DUSP7 content in vitro with IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells
- Can slow down tumor growth by suppressing SPOP in nude mice (40-80 mg/kg; intraperitoneal injection; daily; for 25 days)
Medchemexpress LLC Nih-12848 | 959551-10-1 | MFCD30738011 | 100.0% | 385.41 g/mol | C20H14F3N3S | 10 MG
NIH-12848 is a small-molecule research reagent that selectively inhibits phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) and is used in biochemical and cellular studies to probe PI5P4Kγ function and signaling pathways. For research use only; not for human or veterinary use.
- Selective PI5P4Kγ inhibition (IC50 ≈ 1 μM).
- No inhibition of PI5P4Kα and PI5P4Kβ at concentrations up to 100 μM.
- High supplied purity (99.96%).
- Solid, white to off-white powder physical form.
- High solubility in DMSO (≥100 mg/mL).
- Powder stable at -20°C for extended storage (years).
Cayman Chemical ANTIBODY HMN-214 25mg
A prodrug form of the PLK inhibitor HMN-176; decreases MDR1 expression in AB-A.1 cells and in tumors isolated from mice bearing multidrug resistant KB-A.1. xenografts; reduces tumor volume in PC3, WiDr, and A549 mouse xenograft models at 20 mg/kg per day; does not induce nerve toxicity in rabbit sciatic nerves in vivo at 30 mg/kg per day
Apexbio Technology LLC UK-5099 56396-35-1 50mg
UK-5099 (CAS 56396-35-1) is a potent inhibitor targeting mitochondrial pyruvate carrier (MPC) a transporter facilitating pyruvate translocation across the mitochondrial inner membrane and serving vital functions in carbohydrate lipid and amino acid metabolism UK-5099 exhibits inhibition of pyruvate uptake with a reported Ki of 49 M and fully blocks transport activity at 1 mM Additionally IC50 values of approximately 50 nM have been observed for pyruvate-dependent oxygen consumption in rat liver and cardiac mitochondria Due to its inhibitory profile UK-5099 is frequently employed in metabolic studies to investigate mitochondrial pyruvate transport mechanisms and related biological pathways
Medchemexpress LLC HY-B0228 5g , Adenosine CAS:58-61-7 Purity:>98%
HY-B0228 5g Adenosine CAS: 58-61-7 Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC PF-06761281 | 1854061-19-0 | 99.5% | 50 MG
Research-grade small-molecule inhibitor of the sodium-coupled citrate transporter (NaCT/SLC13A5) for in vitro and in vivo studies of citrate transport and metabolism. Supplied as an off-white to light yellow solid with high purity and characterized potency across cell-based and hepatocyte assays.
- Potent NaCT inhibitor with cellular IC50 ≈ 0.51 μM.
- Partial selectivity versus NaDC1 and NaDC3 (IC50 ≈ 13.2 μM and 14.1 μM).
- Demonstrated activity in hepatocytes (rat 0.12 μM, mouse 0.21 μM, human 0.74 μM).
- High purity solid, suitable for biochemical and pharmacology studies.
- Soluble in aqueous media at experimental concentrations; store sealed at -20°C.
- Available in small-mass quantities for research use.
Cayman Chemical ANTIBODY SB 204990 5mg
A cell-permeable prodrug of SB 201076; inhibits fatty acid and cholesterol synthesis in HepG2 cells in a concentration-dependent manner; reduces plasma levels of the lipoproteins VLDL, LDL, and HDL by 21, 40, and 22%, respectively, in dogs when administered orally at a dose of 25 mg/kg; reduces VLDL synthesis and plasma cholesterol and triglyceride levels in rats in a dose-dependent manner
eMolecules 2393840-15-6 | Medchem Express | LEI-401 | 5mg | 552386634 | HY-131181 | 421.545 | C24H31N5O2
ChemScene | 46-Dichloro-2-(thiophen-2-yl)pyrimidine | 100mg | 768993954 | CS-0613399 | 57059-13-9 | MFCD11046813 | 231.090 | C8H4Cl2N2S
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Cayman Chemical ANTIBODY FH535 5mg
An inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ; blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ; selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway
Medchemexpress LLC VEGF-C Human HEK29 20ug | 20ug
VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways As part of this family VEGF-C may share features with related proteins that promote cell growth angiogenesis and lymphangiogenesis VEGF-C Protein Human (HEK293 His-Avi) is the recombinant human-derived VEGF-C protein expressed by HEK293 with C-Avi C-His labeled tag
Medchemexpress LLC trans-Zeatinriboside | 6025-53-2 | 99.8% | 351.36 | 5 MG
trans-Zeatinriboside is a type of cytokinin precursor that acts as a major long-distance signaling form in xylem vessels, regulating leaf size and meristem activity-related traits.
- Cytokinin precursor
- Major long-distance signaling form in xylem vessels
- Regulates leaf size
- Regulates meristem activity-related traits
- For research use only
Medchemexpress LLC MA-0204 25mg | 2095128-17-7 | 25 MG
MA-0204 is a potent, highly selective, orally available peroxisome proliferator-activated receptor delta (PPARδ) modulator supplied for research use. It is characterized by CAS 2095128-17-7, molecular weight 476.49 g/mol, and chemical formula C25H27F3N2O4. The compound is provided at high purity for in vitro and pharmacology studies; it is not for human or veterinary use.
- Potent, selective modulation of PPARδ.
- High purity suitable for research applications.
- Supplied as a solid small-molecule in multiple laboratory pack sizes.
- Appropriate for in vitro pharmacology, SAR, and preclinical studies.
- Not for clinical, human, or veterinary use.
Cayman Chemical 3 4MethylendIoxy PyrovalRo 5mg
A metabolite produced during phase I metabolism of 3,4-MDPV